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Intraoperative optimization of seed implantation plan in breast brachytherapy

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

Low-dose-rate permanent-seed (LDR-PS) brachytherapy has shown a great potential for treating breast cancer. An implantation scheme indicating the template pose and needle trajectories is determined before the operation. However, when performing the pre-planned scheme intraoperatively, a change of the patient’s posture will cause seed placements away from the desired locations. Hence, the implantation scheme should update based on the current patient’s posture.

Methods

A numerical method of optimizing the implantation scheme for the LDR-PS breast brachytherapy is presented here. The proposed algorithm determines the fewest needle trajectories and template poses for delivering the seeds to the intraoperative desired locations. The clinical demand, such as the minimum distance between the chest wall and the needle, is considered in the optimization process.

Results

The method was simulated for a given LDR-PS brachytherapy procedure to evaluate the optimal scheme as the number of the template poses changing. The optimization parameters of the needles’ number and the implantation errors are used to adjust the algorithm outcome. The results show that the implantation schemes obtained by our method have a satisfactory accuracy in the cases of 2 or 3 template poses. The computation time is about 76s to 150s according to the number of the template poses from 1 to 3.

Conclusion

The proposed method can find the optimal implantation scheme corresponding to the current desired seed locations immediately once there is a change of patient’s posture. This work can be applied to the robot-assisted LDR-PS breast brachytherapy for improving the operation accuracy and efficiency.

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Funding

This research was supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada under the Collaborative Health Research Projects (CHRP) Grant #316170 and the China Scholarship Council (CSC) under Grant [2019]06250190.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Alberta, 9211, 116 St NW, Edmonton, AB, T6G 1H9, Canada

    Wanyu Liu, Jay Carriere & Mahdi Tavakoli

  2. School of Mechanical Engineering, Tianjin University, No. 135, Yaguan Road, Jinnan District, Tianjin, 300354, China

    Wanyu Liu & Zhiyong Yang

  3. Division of Radiation Oncology, Tom Baker Cancer Centre, 331 29th St NW, Calgary, AB, T2N 4N2, Canada

    Tyler Meyer & Siraj Husain

  4. Department of Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada

    Ron Sloboda & Nawaid Usmani

Authors
  1. Wanyu Liu
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  2. Jay Carriere
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  3. Tyler Meyer
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  4. Ron Sloboda
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  5. Siraj Husain
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  6. Nawaid Usmani
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  7. Zhiyong Yang
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  8. Mahdi Tavakoli
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Correspondence to Mahdi Tavakoli.

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Liu, W., Carriere, J., Meyer, T. et al. Intraoperative optimization of seed implantation plan in breast brachytherapy. Int J CARS 16, 1027–1035 (2021). https://doi.org/10.1007/s11548-021-02350-z

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  • DOI: https://doi.org/10.1007/s11548-021-02350-z

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