Abstract
Purpose
In low-dose-rate prostate brachytherapy (LDR-PB), treatment planning is the process of determining the arrangement of implantable radioactive sources that radiates the prostate while sparing healthy surrounding tissues. Currently, these plans are prepared manually by experts incorporating the centre’s planning style and guidelines. In this article, we develop a novel framework that can learn a centre’s planning strategy and automatically reproduce rapid clinically acceptable plans.
Methods
The proposed framework is based on conditional generative adversarial networks that learn our centre’s planning style using a pool of 931 historical LDR-PB planning data. Two additional losses that help constrain prohibited needle patterns and produce similar-looking plans are also proposed. Once trained, this model generates an initial distribution of needles which is passed to a planner. The planner then initializes the sources based on the predicted needles and uses a simulated annealing algorithm to optimize their locations further.
Results
Quantitative analysis was carried out on 170 cases which showed the generated plans having similar dosimetry to that of the manual plans but with significantly lower planning durations. Indeed, on the test cases, the clinical target volumes achieving \(100\%\) of the prescribed dose for the generated plans was on average \(98.98\%\) (\(99.36\%\) for manual plans) with an average planning time of \(3.04\pm 1.1\) min (\(20\pm 10\) min for manual plans). Further qualitative analysis was conducted by an expert planner who accepted \(90\%\) of the plans with some changes (\(60\%\) requiring minor changes & \(30\%\) requiring major changes).
Conclusion
The proposed framework demonstrated the ability to rapidly generate quality treatment plans that not only fulfil the dosimetric requirements but also takes into account the centre’s planning style. Adoption of such a framework would save significant amount of time and resources spent on every patient; boosting the overall operational efficiency of this treatment.
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References
Aronowitz JN, Crook JM, Michalski JM, Sylvester JE, Merrick GS, Mawson C, Pratt D, Naidoo D, Butler WM, Karolczuk K (2008) Inter-institutional variation of implant activity for permanent prostate brachytherapy. Brachytherapy 7(4):297–300
Babadagli ME, Doucette J, Usmani N, Amanie J, Murtha A, Yee D, Jamaluddin M, Sloboda RS (2018) Initial clinical assessment of “center-specific” automated treatment plans for low-dose-rate prostate brachytherapy. Brachytherapy 17(2):476–488
Bucci J, Spadinger I, Hilts M, Sidhu S, Smith C, Keyes M, Morris WJ (2002) Urethral and periurethral dosimetry in prostate brachytherapy: is there a convenient surrogate? Int J Radiat Oncol Biol Phys 54(4):1235–1242
Committee CCSA (2019) Canadian cancer statistics 2019. Canadian Cancer Society. http://cancer.ca/Canadian-Cancer-Statistics-2019-EN
D’Souza WD, Meyer R, Thomadsen BR, Ferris M (2001) An iterative sequential mixed-integer approach to automated prostate brachytherapy treatment plan optimization. Phys Med Biol 46(2):297
Ferrari G, Kazareski Y, Laca F, Testuri CE (2014) A model for prostate brachytherapy planning with sources and needles position optimization. Oper Res Health Care 3(1):31–39
Goodfellow I, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S, Courville A, Bengio Y (2014) Generative adversarial nets. In: Advances in neural information processing systems, pp 2672–2680
Guthier C, Aschenbrenner K, Buergy D, Ehmann M, Wenz F, Hesser J (2015) A new optimization method using a compressed sensing inspired solver for real-time ldr-brachytherapy treatment planning. Phys Med Biol 60(6):2179
Isola P, Zhu JY, Zhou T, Efros AA (2017) Image-to-image translation with conditional adversarial networks. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 1125–1134
John S (2005) The Seattle prostate institute approach to treatment planning for permanent implants. In: Dicker AP, Merrick G, Gomella L, Valicenti RK, Waterman F (eds) Basic and advanced techniques in prostate brachytherapy, chap. 15. CRC Press, London, pp 178–201
Keyes M, Crook J, Morris WJ, Morton G, Pickles T, Usmani N, Vigneault E (2013) Canadian prostate brachytherapy in 2012. Can Urol Assoc J 7(1–2):51
Mahdavi SS, Chng N, Spadinger I, Morris WJ, Salcudean SE (2011) Semi-automatic segmentation for prostate interventions. Med Image Anal 15(2):226–237
Mahdavi SS, Peacock MD, Morris WJ, Spadinger IT (2020) Automatic dual air kerma strength treatment planning for focal low-dose-rate prostate brachytherapy boost using dosimetric and geometric constraints. arXiv preprint arXiv:2010.12617
Meyer RR, D’Souza WD, Ferris MC, Thomadsen BR (2003) Mip models and bb strategies in brachytherapy treatment optimization. J Glob Optim 25(1):23–42
Nicolae A, Morton G, Chung H, Loblaw A, Jain S, Mitchell D, Lu L, Helou J, Al-Hanaqta M, Heath E, Ravi A (2017) Evaluation of a machine-learning algorithm for treatment planning in prostate low-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys 97(4):822–829
Nouranian S, Ramezani M, Spadinger I, Morris WJ, Salcudean SE, Abolmaesumi P (2015) Automatic prostate brachytherapy preplanning using joint sparse analysis. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 415–423
Pouliot J, Tremblay D, Roy J, Filice S (1996) Optimization of permanent 125i prostate implants using fast simulated annealing. Int J Radiat Oncol Biol Phys 36(3):711–720
Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70:7–30
Szegedy C, Ioffe S, Vanhoucke V, Alemi A (2017) Inception-v4, inception-resnet and the impact of residual connections on learning. In: Proceedings of the AAAI conference on artificial intelligence, vol 31
Taira AV, Merrick GS, Butler WM, Galbreath RW, Lief J, Adamovich E, Wallner KE (2011) Long-term outcome for clinically localized prostate cancer treated with permanent interstitial brachytherapy. Int J Radiat Oncol Biol Phys 79(5):1336–1342
Funding
This work was supported by the Canadian Institutes of Health Research (CIHR) (Grant Nos. CIHR MOP-1422439, CIHR PJT 152965).
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Implementation of our 3D cGANs technique is available in the following link: https://github.com/tajwarabraraleef/3Dpix2pix-for-prostate-brachytherapy.
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Institutional ethics approval was obtained for the use of clinical data in this study.
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Aleef, T.A., Spadinger, I.T., Peacock, M.D. et al. Centre-specific autonomous treatment plans for prostate brachytherapy using cGANs. Int J CARS 16, 1161–1170 (2021). https://doi.org/10.1007/s11548-021-02405-1
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DOI: https://doi.org/10.1007/s11548-021-02405-1