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Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics

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Abstract

In their 2007 paper, Swierstra and Rip identify characteristic tropes and patterns of moral argumentation in the debate about the ethics of new and emerging science and technologies (or “NEST-ethics”). Taking their NEST-ethics structure as a starting point, we considered the debate about tissue engineering (TE), and argue what aspects we think ought to be a part of a rich and high-quality debate of TE. The debate surrounding TE seems to be predominantly a debate among experts. When considering the NEST-ethics arguments that deal directly with technology, we can generally conclude that consequentialist arguments are by far the most prominently featured in discussions of TE. In addition, many papers discuss principles, rights and duties relevant to aspects of TE, both in a positive and in a critical sense. Justice arguments are only sporadically made, some “good life” arguments are used, others less so (such as the explicit articulation of perceived limits, or the technology as a technological fix for a social problem). Missing topics in the discussion, at least from the perspective of NEST-ethics, are second “level” arguments—those referring to techno-moral change connected to tissue engineering. Currently, the discussion about tissue engineering mostly focuses on its so-called “hard impacts”—quantifiable risks and benefits of the technology. Its “soft impacts”—effects that cannot easily be quantified, such as changes to experience, habits and perceptions, should receive more attention.

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Notes

  1. By “trope”, Swierstra and Rip mean a recurring argument or motif that is supposed to have particular force; an argumentative “pattern” consists of two or more ethical arguments that provoke each other into existence.

  2. See Biojewellery: Designing Rings with Bioengineered Bone Tissue at www.biojewellery.com (last accessed June 3rd, 2012).

  3. Swierstra and Rip understand “technological voluntarists” to mean those that counter arguments of technological determinists (morals cannot influence the course of technological progress) by arguing that technology is influenced constantly by societal forces, and can thus be steered in morally desirable directions (Swierstra et al. Swierstra et al. 2009).

  4. This is an example of the well known fact that researchers often do not ultimately determine the use of the technological artifact they create. A technology may be used for other purposes than it was intended for, thus making it important to engage in an imagination about possible applications of a technology that go beyond the purposes for which it was created. These other applications may raise different questions.

References

  • Adissu, H. A., Asem, E. K., & Lelievre, S. A. (2007). Three-dimensional cell culture to model epithelia in the female reproductive system. Reproductive Sciences, 14(8 suppl), 11–19.

    Article  Google Scholar 

  • Awaya, T. (2005). Common ethical issues in regenerative medicine. Journal of International Bioethique, 16(1–2), 69–75, 192–193.

    Google Scholar 

  • Balharry, D., Sexton, K., & BéruBé, K. A. (2008). An in vitro approach to assess the toxicity of inhaled tobacco smoke components: Nicotine, cadmium, formaldehyde and urethane. Toxicology, 244(1), 66–76.

    Article  Google Scholar 

  • Bates, C. (2011). Stem cell patch could save thousands of pregnancies by repairing foetus’ membrane. Daily Mail. http://www.dailymail.co.uk/health/article-2039201/Premature-birth-Stem-cell-patch-save-thousands-pregnancies-repairing-foetal-membrane.html. Accessed 12 June, 2012.

  • Baum, B. J., & Mooney, D. J. (2000). The impact of tissue engineering on dentistry. The Journal of the American Dental Association, 131(3), 309–318.

    Google Scholar 

  • Baylis, F. (2008). Choosing a path: Setting a course for the journey. The American Journal of Bioethics, 8(12), W4–W6.

    Article  Google Scholar 

  • Black, J. (1997). Thinking twice about “tissue engineering”. IEEE Engineering in Medicine and Biology Magazine, 16(4), 102–104.

    Article  Google Scholar 

  • Boenink, M. S., Swierstra, T., & Stemerding, D. (2010). Anticipating the interaction between technology and morality: A scenario study of experimenting with humans in bionanotechnology. Studies in Ethics, Law and Technology, 4(2), 1–38.

    Article  Google Scholar 

  • Bredehorn, T., & Rudolph, B. (2002). Legal problems in tissue transplantation. Transplantation Proceedings, 34(6), 2345–2346.

    Article  Google Scholar 

  • Bubela, T. M., & Caulfield, T. A. (2004). Do the print media “hype” genetic research? A comparison of newspaper stories and peer-reviewed research papers. Canadian Medical Association Journal, 170(9), 1399–1407.

    Article  Google Scholar 

  • Burri, R. (2007). Deliberating risks under uncertainty: Experience, trust, and attitudes in a Swiss Nanotechnology Stakeholder Discussion Group. Nanoethics, 1(2), 143–154.

    Article  Google Scholar 

  • Burri, R., & Bellucci, S. (2008). Public perception of nanotechnology. Journal of Nanoparticle Research, 10(3), 387–391.

    Article  Google Scholar 

  • Cao, Y., Vacanti, J. P., Paige, K. T., Upton, J., & Vacanti, C. A. (1997). Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plastic and Reconstructive Surgery, 100(2), 297–302.

    Article  Google Scholar 

  • Chan, S., & Harris, J. (2006). Cognitive regeneration or enhancement: The ethical issues. Regenerative Medicine, 1(3), 361–366.

    Article  Google Scholar 

  • Choumerianou, D. M., Dimitriou, H., & Kalmanti, M. (2008). Stem cells: Promises versus limitations. Tissue Engineering Part B: Reviews, 14(1), 53–60.

    Article  Google Scholar 

  • Cogle, C. R., Guthrie, S. M., Sanders, R. C., Allen, W. L., Scott, E. W., & Petersen, B. E. (2003). An overview of stem cell research and regulatory issues. Mayo Clinic Proceedings, 78(8), 993–1003.

    Google Scholar 

  • Cooper, M. (2004). Regenerative medicine: Stem cells and the science of monstrosity. Medical Humanities, 30(1), 12–22.

    Article  Google Scholar 

  • Daar, A. S., Bhatt, A., Court, E., & Singer, P. A. (2004). Stem cell research and transplantation: Science leading ethics. Transplantation Proceedings, 36(8), 2504–2506.

    Article  Google Scholar 

  • Daily Mail Reporter. (2011). US Soldier ‘re-grows leg’ after pioneering injection of pig bladder hormone. Daily Mail. http://www.dailymail.co.uk/news/article-2005595/US-soldier-Isaias-Hernandez-grows-leg-pig-bladder-hormone-injection.html. Accessed 12 June, 2012.

  • De Vries, R. B., Oerlemans, A., Trommelmans, L., Dierickx, K., & Gordijn, B. (2008). Ethical aspects of tissue engineering: A review. Issue Engineering Part B: Reviews, 14(4), 367–375.

    Article  Google Scholar 

  • Derksen, M. -H. (2008). Engineering flesh, towards professional responsibility for ‘lived bodies’ in tissue engineering. Ph.D. Thesis, Technische Universiteit Eindhoven, Eindhoven.

  • Derksen, M. -H., & Horstman, K. (2008). Engineering flesh: Towards an ethics of lived integrity. Medicine, Health Care and Philosophy, 11(3), 269–283.

    Article  Google Scholar 

  • Dhai, A., Moodley, J., McQuoid-Mason, D. J., & Rodeck, C. (2004). Ethical and legal controversies in cloning for biomedical research—a South African perspective. South African Medical Journal, 94(11), 906–909.

    Google Scholar 

  • Dickens, B. M., & Cook, R. J. (2007). Acquiring human embryos for stem-cell research. International Journal of Gynaecology and Obstetrics, 96(1), 67–71.

    Article  Google Scholar 

  • Ebbesen, M., & Jensen, T. G. (2006). Nanomedicine: Techniques, potentials, and ethical implications. Journal of Biomedical and Biotechnology, 2006(5), 51516.

    Google Scholar 

  • Edelman, P., McFarland, D., Mironov, V., & Matheny, J. (2005). Commentary: In vitro-cultured meat production. Tissue Engineering, 11(5–6), 659–662.

    Article  Google Scholar 

  • Enoch, S., Shaaban, H., & Dunn, K. W. (2005). Informed consent should be obtained from patients to use products (skin substitutes) and dressings containing biological material. Journal of Medical Ethics, 31(1), 2–6.

    Article  Google Scholar 

  • EuroSTEC. (2007). European program for soft tissue engineering for congenital birth defects in children. EU contract LSHB-CT-2006-037409.

  • Faulkner, A., Kent, J., Geesink, I., & FitzPatrick, D. (2006). Purity and the dangers of regenerative medicine: Regulatory innovation of human tissue-engineered technology. Social Science and Medicine, 63(9), 2277–2288.

    Article  Google Scholar 

  • Fisk, N. M., Roberts, I. A., Markwald, R., & Mironov, V. (2005). Can routine commercial cord blood banking be scientifically and ethically justified? PLOS Medicine, 2(2), e44.

    Article  Google Scholar 

  • Garner, J. P. (2002). Tissue engineering and the trauma surgeon. Trauma, 4(3), 177–183.

    Article  Google Scholar 

  • Garner, J. P. (2004). Tissue engineering in surgery. Surgeon, 2(2), 70–78.

    Article  Google Scholar 

  • Gaskell, G., Allum, N., Bauer, M., et al. (2000). Biotechnology and the European public. Nature Biotechnology, 18, 935–938.

    Article  Google Scholar 

  • Gassei, K., & Schlatt, S. (2007). Testicular morphogenesis. Annals of the New York Academy of Sciences, 1120(1), 152–167.

    Article  Google Scholar 

  • Gavelin, K., Wilson, R., & Doubleday, R. (2007). Democratic technologies? The final report of the Nanotechnology Engagement Group (NEG). London: Involve.

    Google Scholar 

  • Gilbert, J. L. (2011). The dangers in adopting a tissue-engineering-centric agenda: A president’s perspective. Journal of Biomedical Materials Research, Part A, 96(2), 273–274.

    Article  Google Scholar 

  • Glotz, P., & Bertschi, S. (2006). People, mobiles and society: Concluding insights from an international expert survey. Knowledge, Technology & Policy, 19(2), 69–92.

    Article  Google Scholar 

  • Gordijn, B. (2006). Medical Utopias: Ethical reflections about emerging medical technologies. Leuven: Peeters.

    Google Scholar 

  • Griffith, L. G., & Swartz, M. A. (2006). Capturing complex 3D tissue physiology in vitro. Nature Reviews Molecular Cell Biology, 7(3), 211–224.

    Article  Google Scholar 

  • Gunning, J. (2005). Umbilical cord cell banking—implications for the future. Toxicology and Applied Pharmacology, 207(2 Suppl), 538–543.

    Article  Google Scholar 

  • Hall, V., Stojkovic, P., & Stojkovic, M. (2006). Using therapeutic cloning to fight human disease: A conundrum or reality. Stem Cells, 24(7), 137–1628.

    Article  Google Scholar 

  • Hammerman, M. R., & Cortesini, R. (2004). Organogenesis and tissue engineering. Transplant Immunology, 12(3–4), 191–192.

    Article  Google Scholar 

  • Holm, S. (2006). Are countries that ban human embryonic stem cell research hypocritical? Regenerative medicine, 1(3), 357–359.

    Article  Google Scholar 

  • Ihde, D. (1990). Technology and the life world: From garden to earth. Bloomington: Indiana University Press.

    Google Scholar 

  • Ihde, D. (2002). Bodies in technology. Minneapolis: University of Minnesota Press.

    Google Scholar 

  • Iijima, K., Igawa, Y., Imamura, T., Moriizumi, T., Nikaido, T., Konishi, I., et al. (2007). Transplantation of preserved human amniotic membrane for bladder augmentation in rats. Tissue Engineering, 13(3), 513–524.

    Article  Google Scholar 

  • Irvine, D. J., Stachowiak, A. N., & Hori, Y. (2008). Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity. Seminars in Immunology, 20(2), 137–146.

    Article  Google Scholar 

  • Jean, J., Lapointe, M., Soucy, J., & Pouliot, R. (2009). Development of an in vitro psoriatic skin model by tissue engineering. Journal of Dermatological Science, 53(1), 19–25.

    Article  Google Scholar 

  • Katz, J. (2006). Mobile communication and the transformation of daily life: The next phase of research on mobiles. Knowledge, Technology & Policy, 19(1), 62–71.

    Article  Google Scholar 

  • Kent, J., Faulkner, A., Geesink, I., & FitzPatrick, D. (2006). Culturing cells, reproducing and regulating the self. Body & Society, 12(2), 1–23.

    Article  Google Scholar 

  • Kim, S., & von Recum, H. (2008). Endothelial stem cells and precursors for tissue engineering: Cell source, differentiation, selection, and application. Tissue Engineering Part B: Reviews, 14(1), 133–147.

    Article  Google Scholar 

  • Kirkpatrick, C. J., Fuchs, S., Hermanns, M. I., Peters, K., & Unger, R. E. (2007). Cell culture models of higher complexity in tissue engineering and regenerative medicine. Biomaterials, 28(34), 5193–5198.

    Article  Google Scholar 

  • Kulinowski, K. (2004). Nanotechnology: From “wow” to “yuck”? Bulletin of Science, Technology & Society, 24(1), 13–20.

    Article  Google Scholar 

  • Kurtzberg, J., Lyerly, A. D., & Sugarman, J. (2005). Untying the Gordian knot: Policies, practices, and ethical issues related to banking of umbilical cord blood. The Journal of Clinical Investigation, 115(10), 2592–2597.

    Article  Google Scholar 

  • Langer, R., & Vacanti, J. P. (1993). Tissue engineering. Science, 260(5110), 920–926.

    Article  Google Scholar 

  • Lassen, J., & Jamison, A. (2006). Genetic technologies meet the public. Science, Technology and Human Values, 31(1), 8–28.

    Article  Google Scholar 

  • Leabu, M. (2011). Principlism versus utilitarianism in translational medicine ethics. StudiaUBB Philosophia, 56(2), 10.

    Google Scholar 

  • Levine, A. D. (2010). Insights from patients’ blogs and the need for systematic data on stem cell tourism. American Journal of Bioethics, 10(5), 28–29.

    Article  Google Scholar 

  • Li, G. N., & Hoffman-Kim, D. (2008). Tissue-engineered platforms of axon guidance. Tissue Engineering Part B: Reviews, 14(1), 33–51.

    Article  Google Scholar 

  • Lomax, G. P., Hall, Z. W., & Lo, B. (2007). Responsible oversight of human stem cell research: The California Institute for Regenerative Medicine’s medical and ethical standards. PLoS Medicine, 4(5), e114.

    Article  Google Scholar 

  • Longley, D., & Lawford, P. (2001). Engineering human tissue and regulation: Confronting biology and law to bridge the gaps. Medical Law International, 5(2), 101–115.

    Article  Google Scholar 

  • Lowenheim, H., Dazert, S., Bucheler, M., & Guntinas-Lichius, O. (2003). Regenerative medicine/cellular engineering for diseases of the head and neck. DNA and Cell Biology, 22(9), 547–548.

    Article  Google Scholar 

  • Marris, C. (2001). Public views on GMOs: Deconstructing the myths. Stakeholders in the GMO debate often describe public opinion as irrational. But do they really understand the public? EMBO Reports, 2(7), 545–548.

    Article  Google Scholar 

  • Moise, K. J., Jr. (2005). Umbilical cord stem cells. Obstetrics and Gynecology, 106(6), 1393–1407.

    Article  Google Scholar 

  • Moseley, T. A., Zhu, M., & Hedrick, M. H. (2006). Adipose-derived stem and progenitor cells as fillers in plastic and reconstructive surgery. Plastic and Reconstructive Surgery, 118(3 Suppl), 121S–128S.

    Article  Google Scholar 

  • Multi-Agency Tissue Engineering Science (MATES), Interagency Working Group (IWG). (2007). Advancing tissue science and engineering. A foundation for the future. A multi-agency strategic plan. Tissue Engineering, 13(12), 2825–2826.

    Google Scholar 

  • National Institute of Biomedical Imaging and Bioengineering (NIBIB). (2010). Regenerative Medicine Fact Sheet. http://report.nih.gov/nihfactsheets/Pdfs/RegenerativeMedicine%28NIBIB%29.pdf. Accessed 12 June, 2012.

  • Nerem, R. M. (2006). Tissue engineering: The hope, the hype, and the future. Tissue Engineering, 12(5), 1143–1150.

    Article  Google Scholar 

  • Nieminen, O., & Kurki, P. (2004). Risk management for biological products. International Journal of Pharmaceutical Medicine, 18(3), 149–157.

    Article  Google Scholar 

  • Oerlemans, A. J., Rodrigues, C. H., Verkerk, M. A., van den Berg, P. P., & Dekkers, W. J. (2010). Ethical aspects of soft tissue engineering for congenital birth defects in children—what do experts in the field say? Tissue Engineering Part B Reviews, 16(4), 397–403.

    Article  Google Scholar 

  • Oerlemans, A. J., van den Berg, P. P., van Leeuwen, E., & Dekkers, W. J. (2011). Ethical issues regarding the donation and source of cells for tissue engineering: A European focus group study. Tissue Engineering Part B Reviews, 17(4), 229–234.

    Article  Google Scholar 

  • Oerlemans, A. J. M., Feitz, W. F. J., van Leeuwen, E., & Dekkers, W. J. M. (2012). Regenerative urology clinical trials: An ethical assessment of road blocks and solutions (forthcoming).

  • Olson, J. L., Atala, A., & Yoo, J. J. (2011). Tissue engineering: Current strategies and future directions. Chonnam Medical Journal, 47(1), 1–13.

    Article  Google Scholar 

  • Orr, S., Alexandre, E., Clark, B., Combes, R., Fels, L. M., Gray, N., et al. (2002). The establishment of a network of European human research tissue banks. Cell Tissue Bank, 3(2), 133–137.

    Article  Google Scholar 

  • Parson, A. (2006). A tissue engineer sows cells and grows organs. New York Times. http://www.nytimes.com/2006/07/11/health/11prof.html?pagewanted=all. Accessed 12 June, 2012.

  • Pascal, P., Damour, O., Colpart, J. J., & Braye, F. (2000). French legal framework relating to human tissues and cells. Medical & Biological Engineering & Computing, 38(2), 241–247.

    Article  Google Scholar 

  • Patrick, C. W. (2004). Breast tissue engineering. Annual Review of Biomedical Engineering, 6, 109–130.

    Article  Google Scholar 

  • Polak, D. J. (2010). Regenerative medicine. Opportunities and challenges: A brief overview. J R Soc Interface, 7(Suppl 6), S777–781.

    Google Scholar 

  • Poumay, Y., & Coquette, A. (2007). Modelling the human epidermis in vitro: Tools for basic and applied research. Archives of Dermatological Research, 298(8), 361–369.

    Article  Google Scholar 

  • Resnik, D. B. (2002). The commercialization of human stem cells: Ethical and policy issues. Health Care Analysis, 10(2), 127–154.

    Article  Google Scholar 

  • Rogers-Hayden, T., & Pidgeon, N. (2006). Reflecting upon the UK’s Citizen’s Jury on nanotechnologies: NanoJury UK. Nanotechnology, Law and Business, 3(2).

  • Royal Netherlands Academy of Arts and Sciences (Ed.). (2009). Well underway. Opportunities for regenerative medicine in the Netherlands (Vol. 14, Foresight studies). Amsterdam: KNAW.

  • Salvaterra, E., Lecchi, L., Giovanelli, S., Butti, B., Bardella, M. T., Bertazzi, P. A., et al. (2008). Banking together. A unified model of informed consent for biobanking. EMBO Reports, 9(4), 307–313.

    Article  Google Scholar 

  • Samanta, A., Samanta, J., & Price, D. (2004). Who owns my body—thee or me? The human tissue story continues. Clinical Medicine, 4(4), 327–331.

    Article  Google Scholar 

  • Satava, R. M. (2003). Biomedical, ethical, and moral issues being forced by advanced medical technologies. Proceedings of the American Philosophical Society, 147(3), 246–258.

    Google Scholar 

  • Schwab, I. R., Johnson, N. T., & Harkin, D. G. (2006). Inherent risks associated with manufacture of bioengineered ocular surface tissue. Archives of Ophthalmology, 124(12), 1734–1740.

    Article  Google Scholar 

  • Siegelbaum, D. (2008). In search of a test-tube hamburger. Time. http://www.time.com/time/health/article/0,8599,1734630,00.html. Accessed 12 June, 2012.

  • Smith, D. S. (2006). The government’s role in advancing regenerative medicine and tissue engineering—science, safety, and ethics. Periodontol, 2000(41), 16–29.

    Article  Google Scholar 

  • Sofaer, N., & Eyal, N. (2010). The diverse ethics of translational research. The American Journal of Bioethics, 10(8), 19–30.

    Article  Google Scholar 

  • Solbakk, J. H. (2006). Stem cell research and the ethics of transparency. Regenerative medicine, 1(6), 831–835.

    Article  Google Scholar 

  • Stover, D. (2000). Growing hearts from scratch. Popular Science, 46–50.

  • Svenaeus, F. (2000). The body uncanny—further steps towards a phenomenology of illness. Medicine, Healthcare and Philosophy, 3(2), 125–137.

    Article  Google Scholar 

  • Svenaeus, F. (2001). The phenomenology of health and illness. In S. Toombs (Ed.), Handbook of phenomenology and medicine (pp. 87–108). Dordrecht: Kluwer.

    Chapter  Google Scholar 

  • Swierstra, T., & Rip, A. (2007). Nano-ethics as NEST-ethics: Patterns of moral argumentation about new and emerging science and technology. Nanoethics, 1(1), 3–20.

    Article  Google Scholar 

  • Swierstra, T., & Te Molder, H. (2012). Risk and soft impacts. In S. Roeser, R. Hillerbrand, M. Petersen, & P. Sandin (Eds.), Handbook of risk theory (pp. 1050–1066). Dordrecht: Springer.

    Google Scholar 

  • Swierstra, T., Stemerding, D., & Boenink, M. (2009). Exploring techno-moral change: The case of the obesity pill. In P. Sollie & M. Düwell (Eds.), Evaluating new technologies, methodological problems for the ethical assessment of technology developments (pp. 119–138). Dordrecht: Springer.

    Chapter  Google Scholar 

  • Tanaka, Y., Sato, K., Shimizu, T., Yamato, M., Okano, T., & Kitamori, T. (2007). Biological cells on microchips: New technologies and applications. Biosensors & Bioelectronics, 23(4), 449–458.

    Article  Google Scholar 

  • Thacker, E. (2002). Bio-X: Removing bodily contingency in regenerative medicine. Journal of Medical Humanities, 23(3), 239–253.

    Article  Google Scholar 

  • Thasler, W. E., Weiss, T. S., Schillhorn, K., Stoll, P. T., Irrgang, B., & Jauch, K. W. (2003). Charitable state-controlled foundation human tissue and cell research: Ethic and legal aspects in the supply of surgically removed human tissue for research in the academic and commercial sector in Germany. Cell Tissue Bank, 4(1), 49–56.

    Article  Google Scholar 

  • Thompson, C. (2007). Why we should, in fact, pay for egg donation. Regenerative medicine, 2(2), 203–209.

    Article  Google Scholar 

  • Timothy, C. (2004). Biotechnology and the popular press: Hype and the selling of science. Trends in Biotechnology, 22(7), 337–339.

    Article  Google Scholar 

  • Trewavas, A., & Leaver, C. (2001). Is opposition to GM crops science or politics? EMBO Reports, 2(6), 455–459.

    Google Scholar 

  • Trommelmans, L., & Dierickx, K. (2009). Standard of care in clinical research with human tissue engineered products (HTEPs). The American Journal of Bioethics, 9(3), 44–45.

    Article  Google Scholar 

  • Trommelmans, L., Selling, J., & Dierickx, K. (2007). A critical assessment of the directive on tissue engineering of the European Union. Tissue Engineering, 13(4), 667–672.

    Article  Google Scholar 

  • Trommelmans, L., Selling, J., & Dierickx, K. (2008a). Ethical reflections on clinical trials with human tissue engineered products. Journal of Medical Ethics, 34(9), e1.

    Article  Google Scholar 

  • Trommelmans, L., Selling, J., & Dierickx, K. (2008b). Informing participants in clinical trials with ex vivo human tissue-engineered products: What to tell and how to tell it? Journal of Tissue Engineering and Regenerative Medicine, 2(4), 236–241.

    Article  Google Scholar 

  • Trommelmans, L., Selling, J., & Dierickx, K. (2009a). An exploratory survey on the views of European tissue engineers concerning the ethical issues of tissue engineering research. Tissue Enginering Part B Reviews, 15(3), 241–247.

    Article  Google Scholar 

  • Trommelmans, L., Selling, J., & Dierickx, K. (2009b). Is tissue engineering a new paradigm in medicine? Consequences for the ethical evaluation of tissue engineering research. Medicine, Health Care and Philosophy, 12(4), 459–467.

    Article  Google Scholar 

  • Trouet, C. (2004). New European guidelines for the use of stored human biological materials in biomedical research. Journal of Medical Ethics, 30(1), 99–103.

    Article  Google Scholar 

  • Tsang, L. (2005). Legal and ethical status of stem cells as medicinal products. Advanced Drug Delivery Reviews, 57(13), 1970–1980.

    Article  Google Scholar 

  • Tung, L., & Cysyk, J. (2007). Imaging fibrillation/defibrillation in a dish. Journal of Electrocardiology, 40(6, Supplement 1), S62–S65.

    Google Scholar 

  • Tveit, G., Madsen, K., & Sandoe, P. (2003). Biotechnology and the public. Danish Centre for Bioethics and Risk Assessment.

  • Tzanakakis, E. S., Hess, D. J., Sielaff, T. D., & Hu, W. S. (2000). Extracorporeal tissue engineered liver-assist devices. Annual Review of Biomedical Engineering, 2, 607–632.

    Article  Google Scholar 

  • Vacanti, C. A. (2006). History of tissue engineering and a glimpse into its future. Tissue Engineering, 12(5), 1137–1142.

    Article  Google Scholar 

  • Van Blitterswijk, C. A., Moroni, L., Rouwkema, J., Siddappa, R., & Sohier, J. (2008). Tissue engineering—an introduction. In C. van Blitterswijk, P. Thomsen, A. Lindahl, J. Hubbell, D.F. Williams, R. Cancedda, J.D. de Bruijn, J. Sohier (Eds.), Tissue Engineering (pp. xii–xxxvi). Burlington: Academic Press.

  • Van der Burg, S. (2009). Taking the “soft impacts” of technology into account: Broadening the discourse in research practice. Social Epistemology, 23(3), 301–316.

    Article  Google Scholar 

  • Yoshimura, Y. (2006). Bioethical aspects of regenerative and reproductive medicine. Human Cell, 19(2), 83–86.

    Google Scholar 

  • Weiss, G. (1999). Body images: Embodiment as intercorporeality. New York/London: Routledge.

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The research for this contribution was funded by the European Commission (EuroSTEC: EU contract LSHB-CT-2006-037409).

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Oerlemans, A.J.M., van Hoek, M.E.C., van Leeuwen, E. et al. Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics. Sci Eng Ethics 19, 963–981 (2013). https://doi.org/10.1007/s11948-012-9419-y

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