Abstract
This article addresses the problem of identification of partly destroyed human melanoma cancer cells in confocal microscopy imaging. Complete cancer cells are nearly circular and most of them have a nearly homogeneous boundary and interior region. A deformable template (Grenander, 1993) is well suited for these complete cells and models a cell as a natural deformed template or prototype. We will in this article focus on the remaining cells which have lost parts of the boundary region most probably due to a 'capping' phenomenon. We can interpret these cells as being partly destroyed, where in our statistical model the lost part of the boundary region is generated by a destructive deformation field acting and living on the cell or template. By doing simultaneous inference for both the natural and destructive deformation field, we are able to obtain reliable estimates of the outline in addition to where on the boundary the cell is destroyed. We apply our model to identifying partly destroyed human melanoma cancer cells with good results.
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Rue, H., Husby, O.K. Identification of partly destroyed objects using deformable templates. Statistics and Computing 8, 221–228 (1998). https://doi.org/10.1023/A:1008953210305
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DOI: https://doi.org/10.1023/A:1008953210305