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Enhancement of the interaction between low‐intensity R.F. e.m. fields and ligand binding due to cell basal metabolism

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Abstract

Power absorption by biological tissues, due to low‐intensity electromagnetic exposure at radio frequencies, as those generated by personal telecommunication systems, is typically negligible. Nevertheless, the electromagnetic field is able to affect biological processes, like the binding of a messenger ion to a cell membrane receptor, if some specific conditions occur. The depth of the attracting potential energy well of the binding site must be comparable with the radio frequency photon energy. The dependance of the binding potential energy on the spatial coordinates must be highly non‐linear. The ion–receptor system, in absence of the exogenous electromagnetic exposure, must be biased out of thermodynamic equilibrium by the cell basal metabolism. When the above conditions concur a low‐intensity radio frequency sinusoidal field is able to induce a steady change of the ion binding probability, which overcomes thermal noise. The model incorporates the effects of both thermal noise and basal metabolism, so that it offers a plausible biophysical basis for potential bioeffects of electromagnetic fields, e.g., those generated by mobile communication systems.

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References

  1. A. Abragam, The Principles of Nuclear Magnetism (Clarendon Press, Oxford, 1961) pp. 264–353.

    Google Scholar 

  2. W.R. Adey, Frequency and power windowing in tissue interactions with weak electromagnetic fields, Proc. IEEE 68 (1980) 119–125.

    Google Scholar 

  3. R.D. Astumian, J.C. Weaver and R.K. Adair, Rectification and signal averaging of weak electric fields by biological cells, Proc. Nat. Acad. Sci. U.S.A. 92 (1995) 3740–3743.

    Google Scholar 

  4. J.B. Andersen, C. Johansen, G.F. Pedersen and P. Raskmark, On the possible health effects related to GSM and DECT transmissions, A tutorial study for the European Commission, Aalborg Univ., Denmark (April 1995).

    Google Scholar 

  5. R. Balian, From Microphysics to Macrophysics, Vols. I and II (Springer, Berlin, 1992).

    Google Scholar 

  6. S.M. Bawin and W.R. Adey, Sensitivity of calcium binding in central tissue to weak environmental electric fields oscillating at low frequency, Proc. Nat. Acad. U.S.A. 73 (1976) 1999–2003.

    Google Scholar 

  7. B. Bianco and A. Chiabrera, From the Langevin–Lorentz to the Zeeman model of electromagnetic effects on ligand–receptor binding, Bioelectrochem. Bioenerg. 28 (1992) 355–365.

    Google Scholar 

  8. B. Bianco, A. Chiabrera, E. Moggia and T. Tommasi, Interaction mechanisms between electromagnetic fields and biological samples under a TEM exposure system, in: 2nd Int. IEEE–URSI Scient. Meet. Microwave in Medicine, Rome, Italy (October 11–14, 1993).

  9. B. Bianco, A. Chiabrera, G. D'Inzeo, A. Galli and A. Palombo, Comparison between classical and quantum modelling of bioelectromagnetic interaction mechanisms, in: Electricity and Magnetism in Biology and Medicine, ed. M. Blank (San Francisco Press, San Francisco, 1993) pp. 537–539.

    Google Scholar 

  10. B. Bianco, Internal Report, DIBE, Italy (1994).

    Google Scholar 

  11. B. Bianco, A. Chiabrera and J.J. Kaufman, A new paradigm for studying the interaction of electromagnetic fields with living systems: an out-of-equilibrium characterization, in: BEMS 7th Annual Meet., Boston, USA (June 18–22, 1995).

  12. C.F. Blackman, S.G. Benane, J.R. Robinovitz, D.E. House and W.T. Joines, A role for the magnetic field in the radiation-induced efflux of calcium ions from brain tissue in vitro, Bioelectromagnetics 6 (1985) 327–337.

    Google Scholar 

  13. C.F. Blackman, J.P. Blanchard, S.G. Benane and D.E. House, The ion parametric resonance model predicts magnetic field parameters that affect nerve cells, FASEB J. 9 (1995) 547–551.

    Google Scholar 

  14. J.P. Blanchard and C.F. Blackman, Clarification and application of an ion parametric resonance model for magnetic field interactions with biological systems, Bioelectromagnetics 15 (1994) 217–238.

    Google Scholar 

  15. D.O. Carpenter and S. Ayrapetyan, eds., Biological Effects of Electric and Magnetic Fields, Vols. I and II (Academic Press, San Diego, 1994).

    Google Scholar 

  16. M. Cavanna, E. Moggia and A. Chiabrera, Reaction of a receptor protein to ligand binding under e.m. exposure, in: 18th Annual Int. Conf. IEEE Engineering in Medicine and Biology Soc., Amsterdam, The Netherlands (October 31–November 3 1996).

  17. A. Chiabrera, A. Morro and M. Parodi, Water concentration and dielectric permittivity in molecular crevices, Il Nuovo Cimento sect. IID 7 (1989) 981–992.

    Google Scholar 

  18. A. Chiabrera, B. Bianco, M.N. Liebman, J.J. Kaufman and A.A. Pilla, Movement of ions near macromolecules in the presence of electromagnetic exposure, in: BRAGS 10th Annual Meet., Philadelphia, USA (October 14–17, 1990).

  19. A. Chiabrera, B. Bianco, M. Parodi, A. Morro and M.N. Liebman, Hydrophobicity of ion binding sites in proteins, in: BEMS 13th Annual Meet., Salt Lake City, USA (June 23–27, 1991).

  20. A. Chiabrera, B. Bianco, J.J. Kaufman and A.A. Pilla, Quantum dynamics of ion in molecular crevices under electromagnetic exposure, in: Electromagnetics in Biology and Medicine, eds. C.T. Brighton and S.R. Pollak (San Francisco Press, San Francisco, 1991) pp. 21–26.

    Google Scholar 

  21. A. Chiabrera, B. Bianco, T. Tommasi and E. Moggia, Langevin– Lorentz and Zeeman–Stark models of bioelectromagnetic effects, Acta Pharm. 42 (1992) 315–322.

    Google Scholar 

  22. A. Chiabrera, B. Bianco, J.J. Kaufman and A.A. Pilla, Bioelectromagnetic resonance interactions: endogenous field and noise, in: Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems, eds. B. Norden and C. Ramel (Oxford Science Publications, Oxford, 1992) pp. 164–179.

    Google Scholar 

  23. A. Chiabrera, B. Bianco and E. Bianco, Effects of lifetimes on ligand binding modelled by the density operator, Bioelectrochem. Bioenerg. 30 (1993) 35–42.

    Google Scholar 

  24. A. Chiabrera, B. Bianco, E. Moggia and T. Tommasi, The out-ofequilibrium steady state of a cell as reference for evaluating bioelectromagnetic effects, in: BEMS 16th Annual Meet., Copenhagen, Denmark (June 12–17, 1994).

  25. A. Chiabrera, B. Bianco, E. Moggia and T. Tommasi, The interaction mechanism between e.m. fields and ion adsorption: endogenous forces and collision frequency, Bioelectrochem. Bioenerg. 35 (1994) 33–37.

    Google Scholar 

  26. A. Chiabrera, B. Bianco and J.J. Kaufman, Biological effectiveness of low intensity electromagnetic exposure: non-linearity, outof-equilibrium state and noise, in: Electromagnetic Compatibility, EMC '95, URSI Open Meet., Commission K, Zurich, Switzerland (March 7–9, 1995).

  27. A. Chiabrera, B. Bianco, E. Moggia, T. Tommasi and J.J. Kaufman, Recent advances in biophysical modelling of radio frequency electromagnetic field interactions with living systems, Invited Paper, in: Proceedings of the State of the Science Colloquium, WTR and ICWCHR, Rome (November 13–15, 1995).

  28. C. Cohen-Tannoudji, B. Diu and F. Laloe, Quantum Mechanics, Vols. I and II (Wiley, New York, 1977) pp. 305–307.

    Google Scholar 

  29. Comments on clarification and application of an ion parametric resonance model for magnetic field interactions with biological systems, Bioelectromagnetics 16 (1995) 268–275.

  30. J.K. Douglass, L. Wilkens, E. Pantazaleou and F. Moss, Noise enhancement of information transfer in crayfish mechanoreceptors by stochastic resonance, Nature 385 (1993) 337–340.

    Google Scholar 

  31. C. Eichwald and F. Kaiser, Model of external influences on celllar signal transduction pathways including cytosolic calcium oscillations, Bioelectromagnetics 16 (1995) 75–85.

    Google Scholar 

  32. S. Engstrom, Dynamic properties of Lednev's parametric resonance mechanism, Bioelectromagnetics 17 (1996) 58–70.

    Google Scholar 

  33. W. Grundler, F. Kaiser, F. Keilman and J. Walleczek, Mechanisms of electromagnetic interaction with cellular systems, Naturwissenschaften 79 (1994) 551–559.

    Google Scholar 

  34. H. Hochstadt, Differential Equations (Dover, New York, 1975) pp. 191–203.

    Google Scholar 

  35. J.J. Kaufman, A. Chiabrera, M. Hatem, B. Bianco and A. Pilla, Numerical stochastic analysis of Lorentz force ion binding kinetics in electromagnetic bioeffects, in: BRAGS 10th Annual Meet., Philadelphia, USA (October 14–17, 1990).

  36. I.L. Kruglkov and H. Dertinger, Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells, Bioelectromagnetics 15 (1994) 539–547.

    Google Scholar 

  37. L. Landau and E. Lifschitz, Quantum Mechanics (Moscow, Mir, 1966).

  38. H. Lay, A. Horita and A.W. Guy, Microwave irradiation affects radial-arm maze performance in the rat, Bioelectromagnetics 15 (1994) 95–104.

    Google Scholar 

  39. V.V. Lednev, Possible mechanism for the influence of weak magnetic fields on biological systems, Bioelectromagnetics 12 (1991) 71–75.

    Google Scholar 

  40. V. V. Lednev, Interference with the vibrational energy sublevels of ions bound in calcium-binding proteins as the basis for the interaction of weak magnetic fields with biological systems, in: On the Nature of Electromagnetic Field Interactions With Biological Systems, ed. A.H. Frey (RG Landes Company, Medical Intelligence Unit, Boca Ranton, FL, 1994) pp. 59–72.

    Google Scholar 

  41. V.O.K. Li and X. Qiu, Personal Communication Systems (PCS), Proc. IEEE 83 (1995) 1210–1243.

    Google Scholar 

  42. D. Miklavcic, R. Karba, L. Vodovnik and A. Chiabrera, eds., Advances in Bioelectromagnetics, Proceedings of the 2nd EBEA Congress, Bioelectrochem. Bioenerg. 35 (1994).

  43. E. Moggia, M. Cavanna and A. Chiabrera, The reaction component of the endogenous field in receptor proteins, in: EBEA '96, COST 244 Congress, Nancy, France (February 28–March 2, 1996).

  44. E. Moggia, T. Tommasi, B. Bianco and A. Chiabrera, Comparison of five-state vs three-state coulombic Zeeman model of EMF effects on ligand binding, in: Electricity and Magnetism in Biology and Medicine, ed. M. Blank (San Francisco Press, San Francisco, 1993) pp. 556–558.

    Google Scholar 

  45. E. Ott and M. Spano, Controlling caos, Physics Today (May 1995) 34–40.

  46. V. Poponin, Nonlinear stochastic resonance in weak emf interactions with diamagnetic ions bound within proteins, in: Charge and Field Effects in Biosystems, Vol. 4, eds. M.J. Allen, S.F. Clearly and A.E. Sowers (World Scientific, Singapore, 1994) pp. 306–319.

    Google Scholar 

  47. Proceedings of the State of the Science Colloquium, WTR and ICWCHR, Rome (November 13–15, 1995).

  48. M. Sargent III, M.O. Scully and W.E. Lamb, Laser Physics (Addison-Wesley Reading, MA, 1974) pp. 79–95.

    Google Scholar 

  49. L.I. Shiff, Quantum Mechanics (McGraw Hill, New York, 1955) pp. 69–79.

    Google Scholar 

  50. D. Simunic, ed., Proceedings of the COST 244 Workshop on Mobile Communications and Extremely Low Frequency Fields, European Commission, DGXIII, Bled, Slovenia (December 10–12, 1993).

    Google Scholar 

  51. D. Simunic, ed., Proceedings of the COST 244 Workshop on Biomedical Effects Relevant to Amplitude Modulated RF Fields, European Commission, DGXIII, Kuopio, Finland (September 3–4, 1995).

    Google Scholar 

  52. D. Ter Haar, Theory and applications of the density matrix, Rep. Progr. Phys. 24 (1961) 304–362.

    Google Scholar 

  53. J.C. Weaver and R.D. Astumian, The thermal noise limit for threshold effects of electric and magnetic fields in biological systems, in: Biological Effects of Electric and Magnetic Fields, eds. D.O. Carpenter and S. Ayrapetyan (Academic Press, San Diego, 1994) pp. 83–104.

    Google Scholar 

  54. K. Wiesenfeld and F. Moss, Stochastic resonance and the benefits of noise from ice ages to crayfish and SQUIDs, Nature 373 (1995) 33–36.

    Google Scholar 

  55. M.M. Yamashita, L. Wesson, G. Eisenman and D. Eisenberg, Where metal ions bind in proteins, Proc. Nat. Acad. Sci. U.S.A. 87 (1990) 5648–5652.

    Google Scholar 

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Authors and Affiliations

  1. ICEmB at Department of Biophysical and Electronic Engineering, University of Genoa, Via Opera Pia 11a, 16145, Genoa, Italy

    B. Bianco, A. Chiabrera, E. Moggia & T. Tommasi

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  1. B. Bianco
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  2. A. Chiabrera
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  3. E. Moggia
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  4. T. Tommasi
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Bianco, B., Chiabrera, A., Moggia, E. et al. Enhancement of the interaction between low‐intensity R.F. e.m. fields and ligand binding due to cell basal metabolism. Wireless Networks 3, 477–487 (1997). https://doi.org/10.1023/A:1019106728587

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