Normative modeling is considered one of the most promising avenues towards personalized medicine. The integration of multimodal, mechanistic and lifespan modeling will play an essential role, but significant challenges need to be overcome before this promise can be turned into reality.
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References
Cole, T. J. Ann. Hum. Biol. 39, 382–394 (2012).
Marquand, A. F. Mol. Psychiatry 24, 1415–1424 (2019).
Marquand, A. F., Wolfers, T., Mennes, M., Buitelaar, J. & Beckmann, C. F. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 1, 433–447 (2016).
Wolfers, T. et al. Hum. Brain Mapp. 42, 2546–2555 (2021).
Wolfers, T. et al. JAMA Psychiatry 75, 1146–1155 (2018).
Bethlehem, R. A. I. et al. Commun. Biol. 3, 486 (2020).
Wolfers, T. et al. Psychol. Med. 50, 314–323 (2020).
Pinaya, W. L. et al. Sci. Rep. 11, 15746 (2021).
Tetreault, A. M. et al. Brain 143, 1249–1260 (2020).
Chen, C.-L. et al. Preprint at https://www.medrxiv.org/content/10.1101/2020.11.09.20228064v1 (2020).
Cropley, V. L. et al. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 6, 410–419 (2021).
Insel, T. et al. Am. J. Psychiatry 167, 748–751 (2010).
Insel, T. R. & Cuthbert, B. N. Science 348, 499–500 (2015).
Dickinson, D. et al. Schizoph. Bull. 44, 101–113 (2017).
Chen, J. et al. Schizophr. Bull. 46, 1165–1171 (2020).
Durstewitz, D., Koppe, G. & Meyer-Lindenberg, A. Mol. Psychiatry 24, 1583–1598 (2019).
Koutsouleris, N. et al. JAMA Psychiatry 78, 195–209 (2021).
Nelson, W. et al. Front. Genet. 10, 381 (2019).
Domingo-Fernandez, D. et al. Bioinformatics 37, 1332–1334 (2021).
Koutsouleris, N. Lancet Digit. Health 1, e244–e245 (2019).
Acknowledgements
This study was supported by the Deutsche Forschungsgemeinschaft (DFG), SCHW 1768/1-1 and the German Federal Ministry of Education and Research (BMBF, grants 01KU1905A and 01ZX1904A).
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Nature Computational Science thanks Richard Bethlehem and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Rieg, T., Schwarz, E. From mechanistic insight towards clinical implementation using normative modeling. Nat Comput Sci 2, 278–280 (2022). https://doi.org/10.1038/s43588-022-00248-7
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DOI: https://doi.org/10.1038/s43588-022-00248-7