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Computation empowers CRISPR discovery and technology

Nature Computational Science volume 2, pages 533–535 (2022)Cite this article

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CRISPR has revolutionized biomedical and bioengineering research as a programmable genome engineering technology. Computational tools have been integral throughout the discovery of CRISPR biology and the development of CRISPR-based technologies that hold promise to solve many challenges ahead.

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Acknowledgements

The authors thank X. Lin for useful discussion. S.S. and L.S.Q. acknowledge support from National Science Foundation CAREER award (to L.S.Q., award no. 2046650). L.S.Q. also acknowledges support from National Science Foundation NSF2026: EAGER (award no. 2033387), National Institutes of Health National Cancer Institute (grant no. 1R01CA266470-01A1, 1R21CA270609-01) and 4D Nucleome (grant no. 1U01DK127405-03), and Stanford Innovative Medicines Accelerator. L.S.Q. is a Chan Zuckerberg Biohub Investigator.

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Authors and Affiliations

  1. Department of Bioengineering, Stanford University, Stanford, CA, USA

    Stephen Shang, Xiangmeng S. Cai & Lei S. Qi

  2. Sarafan ChEM-H, Stanford University, Stanford, CA, USA

    Lei S. Qi

  3. Chan Zuckerberg Biohub, San Francisco, CA, USA

    Lei S. Qi

Authors
  1. Stephen Shang
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  2. Xiangmeng S. Cai
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  3. Lei S. Qi
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Correspondence to Lei S. Qi.

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Competing interests

L.S.Q. is a founder of Epicrispr Biotechnologies and a scientific advisor of Epicrispr Biotechnologies and Laboratory of Genomics Research.

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Shang, S., Cai, X.S. & Qi, L.S. Computation empowers CRISPR discovery and technology. Nat Comput Sci 2, 533–535 (2022). https://doi.org/10.1038/s43588-022-00321-1

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