Prediction of breast biopsy outcome using a likelihood ratio classifier and biopsy cases from two medical centers

Anna O. Bilska-Wolak; Carey E. Floyd Jr.; Joseph Y. Lo

doi:10.1117/12.481349

15 May 2003 Prediction of breast biopsy outcome using a likelihood ratio classifier and biopsy cases from two medical centers

Anna O. Bilska-Wolak, Carey E. Floyd Jr., Joseph Y. Lo

Author Affiliations +

Proceedings Volume 5032, Medical Imaging 2003: Image Processing; (2003) https://doi.org/10.1117/12.481349
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Potential malignancy of a mammographic lesion can be assessed using the mathematically optimal likelihood ratio (LR) from signal detection theory. We developed a LR classifier for prediction of breast biopsy outcome of mammographic masses from BI-RADS findings. We used cases from Duke University Medical Center (645 total, 232 malignant) and University of Pennsylvania (496, 200). The LR was trained and tested alternatively on both subsets. Leave-one-out sampling was used when training and testing was performed on the same data set. When tested on the Duke set, the LR achieved a Received Operating Characteristic (ROC) area of 0.91± 0.01, regardless of whether Duke or Pennsylvania set was used for training. The LR achieved a ROC area of 0.85± 0.02 for the Pennsylvania set, again regardless of which set was used for training. When using actual case data for training, the LR's procedure is equivalent to case-based reasoning, and can explain the classifier's decisions in terms of similarity to other cases. These preliminary results suggest that the LR is a robust classifier for prediction of biopsy outcome using biopsy cases from different medical centers.

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Anna O. Bilska-Wolak, Carey E. Floyd Jr., and Joseph Y. Lo "Prediction of breast biopsy outcome using a likelihood ratio classifier and biopsy cases from two medical centers", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); https://doi.org/10.1117/12.481349

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