Extraction of the cerebral cortical boundaries from MRI for measurement of cortical thickness

Simon Fristed Eskildsen; Mark Uldahl; Lasse Riis Ostergaard

doi:10.1117/12.595145

29 April 2005 Extraction of the cerebral cortical boundaries from MRI for measurement of cortical thickness

Simon Fristed Eskildsen, Mark Uldahl, Lasse Riis Ostergaard

Proceedings Volume 5747, Medical Imaging 2005: Image Processing; (2005) https://doi.org/10.1117/12.595145
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

Several neurodegenerative diseases, such as Alzheimer's disease, cause atrophy of the cerebral cortex. Measurements of cerebral cortical thickness and volume are used in the quantification and localization of atrophy. It is possible to measure the thickness of the cerebral cortex manually from magnetic resonance imaging, but partial volume effects, orthogonality problems, large amounts of manual labor and operator bias makes it difficult to conduct measurements on large patient populations. Automatic quantification and localization of atrophy is a highly desirable goal, as it facilitates the study of early anatomical changes and track disease progression on large populations. The first step in achieving this goal is to develop robust and accurate methods for measuring cortical thickness and volume automatically. We have developed a new method, capable of both extracting surface representations of the cortical boundaries from magnetic resonance imaging and measuring the cortical thickness. Experiments show that the developed method is robust and performs well on datasets of both healthy subjects and subjects suffering from Alzheimer's disease.

Citation Download Citation

Simon Fristed Eskildsen, Mark Uldahl, and Lasse Riis Ostergaard "Extraction of the cerebral cortical boundaries from MRI for measurement of cortical thickness", Proc. SPIE 5747, Medical Imaging 2005: Image Processing, (29 April 2005); https://doi.org/10.1117/12.595145

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available