Multi-Modality fiducial marker for validation of registration of medical images with histology

Rushin Shojaii; Anne L. Martel

doi:10.1117/12.845551

12 March 2010 Multi-Modality fiducial marker for validation of registration of medical images with histology

Rushin Shojaii, Anne L. Martel

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 762331 (2010) https://doi.org/10.1117/12.845551
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

A multi-modality fiducial marker is presented in this work, which can be used for validating the correlation of histology images with medical images. This marker can also be used for landmark-based image registration. Seven different fiducial markers including a catheter, spaghetti, black spaghetti, cuttlefish ink, and liquid iron are implanted in a mouse specimen and then investigated based on visibility, localization, size, and stability. The black spaghetti and the mixture of cuttlefish ink and flour are shown to be the most suitable markers. Based on the size of the markers, black spaghetti is more suitable for big specimens and the mixture of the cuttlefish ink, flour, and water injected in a catheter is more suitable for small specimens such as mouse tumours. These markers are visible on medical images and also detectable on histology and optical images of the tissue blocks. The main component in these agents which enhances the contrast is iron.

Citation Download Citation

Rushin Shojaii and Anne L. Martel "Multi-Modality fiducial marker for validation of registration of medical images with histology", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 762331 (12 March 2010); https://doi.org/10.1117/12.845551

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