Fiber estimation errors incurred from truncated sampling in q-space diffusion magnetic resonance imaging

Bryce Wilkins; Namgyun Lee; Manbir Singh

doi:10.1117/12.911155

24 February 2012 Fiber estimation errors incurred from truncated sampling in q-space diffusion magnetic resonance imaging

Bryce Wilkins, Namgyun Lee, Manbir Singh

Author Affiliations +

Proceedings Volume 8314, Medical Imaging 2012: Image Processing; 83144A (2012) https://doi.org/10.1117/12.911155
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

The effect of truncated sphere sampling commonly used in Diffusion Spectrum Imaging to estimate single fiber orientation errors is simulated using fully-sampled (7x7x7) q-space data (343 samples), truncated sphere sampling (203 samples), and zero-padding (to 21x21x21 samples), in both noise-free and noisy (SNR = 30) scenarios. We show that the error of resolving a single fiber direction depends on the fiber orientation relative to the "corners of q-space", which are not sampled when truncated sampling schemes are used, and that corner-samples help reduce the error in estimating a single fiber orientation (mean error 3.5° versus 3.9° for the noise case and zero-padding used). As truncated sphere sampling requires 40% less acquisition time, its use could justify the small increase in error (0.4°). A simulation of the FiberCup phantom was used to assess the significance of truncated sampling on fiber orientation estimation errors over a continuous space of voxels by examining differences in resulting tractography.

Citation Download Citation

Bryce Wilkins, Namgyun Lee, and Manbir Singh "Fiber estimation errors incurred from truncated sampling in q-space diffusion magnetic resonance imaging", Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 83144A (24 February 2012); https://doi.org/10.1117/12.911155

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