Detection of cerebral aneurysms in MRA, CTA and 3D-RA data sets

Clemens M. Hentschke; Oliver Beuing; Rosa Nickl; Klaus D. Tönnies

doi:10.1117/12.911212

23 February 2012 Detection of cerebral aneurysms in MRA, CTA and 3D-RA data sets

Clemens M. Hentschke, Oliver Beuing, Rosa Nickl, Klaus D. Tönnies

Proceedings Volume 8315, Medical Imaging 2012: Computer-Aided Diagnosis; 83151I (2012) https://doi.org/10.1117/12.911212
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

We propose a system to automatically detect cerebral aneurysms in 3D X-ray rotational angiography images (3D-RA), magnetic resonance angiography images (MRA) and computed tomography angiography images (CTA). After image normalization, initial candidates are found by applying a blob-enhancing filter on the data sets. Clusters are computed by a modified k-means algorithm. A post-processing step reduces the false positive (FP) rate on the basis of computed features. This is implemented as a rule-based system that is adapted according to the modality. In MRA, clusters are excluded that are not neighbored to a vessel. As a final step, FP are further reduced by applying a threshold classification on a feature. Our method was tested on 93 angiographic data sets containing aneurysm and non-aneurysm cases. We achieved 95 % sensitivity with an average rate of 2.6 FP per data set (FP/DS) in case of 3D-RA, 89 % sensitivity at 6.6 FP/DS for MRA and 95 % sensitivity at 37.6 FP/DS with CTA, respectively. We showed that our post-processing approach eliminates FP in MRA with only a slight decrease of sensitivity. In contrast to other approaches, our algorithm does not require a vessel segmentation and does not require training of distributional properties.

Citation Download Citation

Clemens M. Hentschke, Oliver Beuing, Rosa Nickl, and Klaus D. Tönnies "Detection of cerebral aneurysms in MRA, CTA and 3D-RA data sets", Proc. SPIE 8315, Medical Imaging 2012: Computer-Aided Diagnosis, 83151I (23 February 2012); https://doi.org/10.1117/12.911212

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