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Voronoi analysis uncovers relationship between mosaics of normally placed and displaced amacrine cells in the thraira retina

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Abstract

Although neuronal dynamics is to a high extent a function of synapse strength, the spatial distribution of neurons is also known to play an important role, which is evidenced by the topographical organization of the main stations of the visual system: retina, lateral geniculate nucleus, and cortex. The coexisting systems of normally placed and displaced amacrine cells in the vertebrate retina provide interesting examples of retinotopic spatial organization. However, it is not clear whether these two systems are spatially interrelated or not. The current work applies two mathematical-computational methods-a new method involving Voronoi diagrams for local density quantification and a more traditional approach, the Ripley K function-in order to characterize the mosaics of normally placed and displaced amacrine cells in the retina of Hoplias malabaricus and search for possible spatial relationships between these two types of mosaics. The results obtained by the Voronoi local density analysis suggest that the two systems of amacrine cells are spatially interrelated through nearly constant local density ratios.

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Authors and Affiliations

  1. Instituto de Física de São Carlos, Universidade de São Paulo, Caixa Postal 369, 13560-970, São Carlos, SP, Brazil

    Luciano Da Fontoura Costa

  2. Instituto de Psicologia, Universidade de São Paulo, Av. Professor Mello Morais, 1721, 05508-900, São Paulo, SP, Brazil

    Daniela Maria Oliveira Bonci, Fernando Allan De Farias Rocha & Dora Fix Ventura

  3. Núcleo de Neurociências e Comportamento, Universidade de São Paulo, Av. Professor Mello Morais, 1721, 05508-900, São Paulo, SP, Brazil

    Daniela Maria Oliveira Bonci & Dora Fix Ventura

  4. Departamento de Fisiologia, Universidade Federal do Pará, Rua Augusto Corrãa, 01, 66075-900, Belém, Pará, Brazil

    Cézar Akiyoshi Saito, Fernando Allan De Farias Rocha & Luiz Carlos De Lima Silveira

  5. Núcleo de Medicina Tropical, Universidade Federal do Pará, Rua Generalíssimo Deodoro, 92, 66055-240, Belém, Pará, Brazil

    Luiz Carlos De Lima Silveira

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  1. Luciano Da Fontoura Costa
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  2. Daniela Maria Oliveira Bonci
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Correspondence to Luciano Da Fontoura Costa.

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Costa, L.D.F., Bonci, D.M.O., Saito, C.A. et al. Voronoi analysis uncovers relationship between mosaics of normally placed and displaced amacrine cells in the thraira retina. Neuroinform 5, 59–77 (2007). https://doi.org/10.1385/NI:5:1:59

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