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A weighted log-rank test for comparing two survival curves

  • Seung-Hwan Lee EMAIL logo and Eun-Joo Lee

Abstract

This paper proposes a weighted log-rank test that maintains sensitivity to realistic alternatives of two survival curves, such as crossing curves, in the presence of heavy censoring. The new test incorporates a weight function that changes over the censoring level, increasing adaptivity and flexibility of the commonly used weighted log-rank tests. The new statistic is asymptotically normal under the null hypothesis that there is no difference in survival between two groups. The performances of the new test are evaluated via simulations under both proportional and non-proportional alternatives. We illustrate the new method with a real-world application.

MSC 2010: 62N01; 62N02

References

[1] S. Buyske, R. Fagerstrom and Z. Ying, A class of weighted log-rank tests for survival data when the event is rare, J. Amer. Statist. Assoc. 95 (2000), no. 449, 249–258. 10.1080/01621459.2000.10473918Search in Google Scholar

[2] D. Collett, Modelling Survival Data in Medical Research, Stat. Distributions 41, Chapman & Hall/CRC, Boca Raton, 1994. 10.1007/978-1-4899-3115-3Search in Google Scholar

[3] T. R. Fleming and D. P. Harrington, A class of hypothesis tests for one- and two-sample censored survival data, Comm. Statist. 10 (1981), no. 8, 763–794. 10.1080/03610928108828073Search in Google Scholar

[4] T. R. Fleming and D. P. Harrington, Counting Processes and Survival Analysis, Wiley Ser. Probab. Math. Stat., John Wiley & Sons, New York, 1991. Search in Google Scholar

[5] T. R. Fleming, D. P. Harrington and M. O’Sullivan, Supremum versions of the log-rank and generalized Wilcoxon statistics, J. Amer. Statist. Assoc. 82 (1987), no. 397, 312–320. 10.1080/01621459.1987.10478435Search in Google Scholar

[6] R. D. Gill, Censoring and Stochastic Integrals, Math. Centre Tracts 124, Mathematisch Centrum, Amsterdam, 1980. 10.1111/j.1467-9574.1980.tb00692.xSearch in Google Scholar

[7] D. P. Harrington and T. R. Fleming, A class of rank test procedures for censored survival data, Biometrika 69 (1982), no. 3, 553–566. 10.1093/biomet/69.3.553Search in Google Scholar

[8] E. L. Kaplan and P. Meier, Nonparametric estimation from incomplete observations, J. Amer. Statist. Assoc. 53 (1958), 457–481. 10.1007/978-1-4612-4380-9_25Search in Google Scholar

[9] M. R. Kosorok and C.-Y. Lin, The versatility of function-indexed weighted log-rank statistics, J. Amer. Statist. Assoc. 94 (1999), no. 445, 320–332. 10.1080/01621459.1999.10473847Search in Google Scholar

[10] A. J. Leathem and S. A. Brooks, Predictive value of lectin binding on breast cancer recurrence and survvial, The Lancet 1 (1987), 1054–1056. 10.1016/S0140-6736(87)90482-XSearch in Google Scholar

[11] S.-H. Lee and E.-J. Lee, On testing equality of two censored samples, J. Stat. Comput. Simul. 79 (2009), no. 1–2, 135–143. 10.1080/00949650701628758Search in Google Scholar

[12] T. A. Louis, Nonparametric analysis of an accelerated failure time model, Biometrika 68 (1981), no. 2, 381–390. 10.1093/biomet/68.2.381Search in Google Scholar

[13] N. Mantel, Evaluation of survival data and two new rank order statistics arising in its consideration, Cancer Chemotherapy Rep. 50 (1966), 163–170. Search in Google Scholar

[14] R. L. Prentice, Linear rank tests with right censored data, Biometrika 65 (1978), no. 1, 167–179. 10.1093/biomet/65.1.167Search in Google Scholar

[15] H. Putter, M. Sasako, H. H. Hartgrink, C. J. H. van de Velde and J. C. van Houwelingen, Long-term survival with non-proportional hazards: Results from the Dutch gastric cancer trial, Stat. Med. 24 (2005), no. 18, 2807–2821. 10.1002/sim.2143Search in Google Scholar PubMed

[16] R. Rebolledo, Central limit theorems for local martingales, Z. Wahrsch. Verw. Gebiete 51 (1980), no. 3, 269–286. 10.1007/BF00587353Search in Google Scholar

[17] S. G. Self, An adaptive weighted log-rank test with application to cancer prevention and screening trials, Biometrics 47 (1991), 975–986. 10.2307/2532653Search in Google Scholar

[18] Y. Shen and J. Cai, Maximum of the weighted Kaplan–Meier tests with application to cancer prevention and screening trials, Biometrics 57 (2001), no. 3, 837–843. 10.1111/j.0006-341X.2001.00837.xSearch in Google Scholar

[19] L. Wu and P. B. Gilbert, Flexible weighted log-rank tests optimal for detecting early and/or late survival differences, Biometrics 58 (2002), no. 4, 997–1004. 10.1111/j.0006-341X.2002.00997.xSearch in Google Scholar PubMed

Received: 2020-02-17
Accepted: 2020-03-28
Published Online: 2020-04-15
Published in Print: 2020-09-01

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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