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Inadequate informatical support of multi-centre clinical trials lead to pure quality. In order to support a multi-centre clinical trial a data collection via WWW and Internet based on Java has been developed. In this study a generalisation and extension of this prototype has been performed. The prototype has been applied to another clinical trial and a knowledge server based on C++ has been integrated via CORBA. The investigation and implementation of security aspects of web-based data collection is now under evaluation.
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