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The roots of interdisciplinary of medical informatics are sought through the analysis of the themes approached by the pioneers of this field. The data included in the study comes mostly from “personal stories” of European these scientists collected by IMIA WG History as well as from some biographical notes. Most researchers came from the technical-scientific field, but the double specialization was very common. The proportions of the main topic approaches are discussed. The roots of medical informatics interdisciplinary were formed during the pioneering period, when most major concepts and chapters of medical informatics took contour.
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