A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip

Wang, Hanfeng; Britton, Charles; Quaiyum, Farhan; Pullano, Salvatore A.; Taylor, Logan; Fiorillo, Antonino S.; Islam, Syed K.

doi:10.1109/TCSII.2018.2798929

Title: A Charge Sensitive Pre-Amplifier for Smart Point-of-Care Devices Employing Polymer Based Lab-on-a-Chip

Journal Article · Fri Jan 26 00:00:00 EST 2018 · IEEE Transactions on Circuits and Systems. II, Express Briefs

DOI:https://doi.org/10.1109/TCSII.2018.2798929· OSTI ID:1422600

Wang, Hanfeng ^[1]; Britton, Charles ^[2]; Quaiyum, Farhan ^[1]; Pullano, Salvatore A. ^[3]; Taylor, Logan ^[1]; Fiorillo, Antonino S. ^[3]; Islam, Syed K. ^[1]

Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States). Dept. of Electrical Engineering and Computer Science
Magna Graecia Univ., Catanzaro (Italy). School of Biomedical Engineering. Dept. of Health Sciences

With increasing emphasis on implantable and portable medical devices, low-power, small-chip-area sensor readout system realized in lab-on-a-chip (LOC) platform is gaining more and more importance these days. The main building blocks of the LOC system include a front-end transducer that generates an electrical signal in response to the presence of an analyte of interest, signal processing electronics to process the signal to comply with a specific transmission protocol and a low-power transmitter, all realized in a single integrated circuit platform. Low power consumption and compactness of the components are essential requirements of the LOC system. This paper presents a novel charge sensitive pre-amplifier developed in a standard 180-nm CMOS process suitable for implementing in an LOC platform. The pre-amplifier converts the charge generated by a pyroelectric transducer into a voltage signal, which provides a measurement of the temperature variation in biological fluids. The proposed design is capable of providing 0.8-mV/pC gain while consuming only 2.1 μW of power. Finally, the pre-amplifier composed of integrated components occupies an area of 0.038 mm².

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