ABSTRACT
A physician education piece on osteoporosis and the mechanism of action of Actonel, a drug for its treatment. Bone is living tissue that is constantly renewed. Cells called osteoclasts remove damaged bone and cells called osteoblasts replace it with new bone. Because estrogen suppresses osteoclast activity, postmenopausal estrogen loss causes an imbalance in favor of the osteoclast, that is, bone removal. When more bone is removed than replaced, bone thinning causes osteoporosis. Actonel is absorbed by bone and ingested by osteoclasts during bone removal. By interfering with cell functioning, Actonel kills osteoclasts. Remodeling balance is restored and osteoporotic fracture risk is reduced. Copyright held by creator.
Supplemental Material
Recommendations
Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine
Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design ...
The analysis of the bone remodelling around femoral stems
In this work the bone tissue remodelling analysis of the femur bone due to the insertion of a stem is analysed. The innovation of this numerical application lies on the use of an efficient advanced discretization meshless technique to obtain the ...
Effects of assessing the bone remodeling process in biomechanical finite element stability evaluations of dental implants
Highlights- The effects of assessing the bone remodeling process in the FE analysis were investigated
- Total six short dental implant systems of various implant diameters and bone qualities were evaluated
- With bone remodeling, bone quality ...
Abstract Background and objectiveWhile an accurate assessment of the biomechanical stability of implants is essential in dental prosthesis planning and associated treatment assurance, the bone remodeling process is often ignored in biomechanical studies ...
Comments