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Simulating data processing for an advanced ion mobility mass spectrometer

Published: 11 November 2007 Publication History

Abstract

We have designed and implemented a Cray XD 1-based simulation of data capture and signal processing for an advanced Ion Mobility mass spectrometer (Hadamard transform Ion Mobility). Our simulation is a hybrid application that uses both an FPGA component and a CPU-based software component to simulate Ion Mobility mass spectrometry data processing. The FPGA component includes data capture and accumulation, as well as a more sophisticated deconvolution algorithm based on a PNNL-developed enhancement to standard Hadamard transform Ion Mobility spectrometry. The software portion is in charge of streaming data to the FPGA and collecting results. We expect the computational and memory addressing logic of the FPGA component to be portable to an instrument-attached FPGA board that can be interfaced with a Hadamard transform Ion Mobility mass spectrometer.

References

[1]
S. K. Bahl and J. Plusquellic. FPGA implementation of a fast Hadamard transformer for WCDMA. In FPGA '03: Proceedings of the 2003 ACM/SIGDA eleventh international symposium on Field programmable gate arrays, pages 237--237, New York, NY, USA, 2003. ACM Press.
[2]
M. Belov, M. Buschbach, D. Prior, K. Tang, and R. Smith. Multiplexed Ion Mobility Spectrometry -- Orthogonal Time-of-Flight Mass Spectrometry. Anal. Chem., 79(6):2451--2462, 2007.
[3]
A. Brock, N. Rodríguez, and R. Zare. Hadamard Transform Time-of-Flight Mass Spectrometry. Anal. Chem., 70:3735--3741, 1998.
[4]
D. Chavarría-Miranda and A. Márquez. Assessing the Potential of Hybrid HPC Systems for Scientific Applications: a case study. In CF '07: Proceedings of the 4th international conference on Computing frontiers, pages 173--182, New York, NY, USA, 2007. ACM Press.
[5]
N. Chen, B. Shi, and N. Wang. Fast communication: A block splitting technique for fast 2D Walsh transform. Signal Process., 87(5):1163--1168, 2007.
[6]
S.-C. Chu, Z.-M. Lu, and J.-S. Pan. Hadamard transform based fast codeword search algorithm for high-dimensional VQ encoding. Inf. Sci., 177(3):734--746, 2007.
[7]
B. H. Clowers, W. F. Siems, H. H. Hill, and S. M. Massick. Hadamard Transform Ion Mobility Spectrometry. Anal. Chem., 78(1):44--51, 2006.
[8]
Cray XD-1 Datasheet. www.cray.com/downloads/Cray_XD1_Datasheet.pdf.
[9]
Direct Connected Processor (DCP) Architecture. www.cray.com/products/xd1/architecture.html.
[10]
M. Harwit and N. J. Sloane. Hadamard Transform Optics. Academic Press, New York, NY, 1979.
[11]
J. Kimmel, F. Fernández, and R. Zare. Effects of Modulation Defects on Hadamard Transform Time-of-Flight Mass Spectrometry (HT-TOFMS). J. Amer. Soc. Mass Spec., 14:278--286, 2003.
[12]
J. R. Kimmel. Continuous, Multiplexed Time-of-Flight Mass Spectrometry of Electrosprayed Ions. PhD thesis, Stanford University, December 2004.
[13]
R. Raulefs, A. Dammann, S. Sand, S. Kaiser, and G. Auer. Rotated walsh-hadamard spreading with robust channel estimation for a coded mc-cdma system. EURASIP J. Wirel. Commun. Netw., 2004(1):74--83, 2004.
[14]
SGI Reconfigurable Application Specific Computing technology. www.sgi.com/products/rasc.
[15]
M. C. Smith, J. S. Vetter, and X. Liang. Accelerating Scientific Applications with the SRC-6 Reconfigurable Computer: Methodologies and Analysis. In IPDPS '05: Proceedings of the 19th IEEE International Parallel and Distributed Processing Symposium (IPDPS'05) -- Workshop 3, page 157.2, Washington, DC, USA, 2005. IEEE Computer Society.
[16]
SRC MAP product line. www.srccomp.com/Products.htm.
[17]
A. Szumlas, S. Ray, and G. Hieftje. Hadamard Transform Ion Mobility Spectrometry. Anal. Chem., 78(1):44--51, 2005.
[18]
J. L. Tripp, A. A. Hanson, M. Gokhale, and H. Mortveit. Partitioning Hardware and Software for Reconfigurable Supercomputing Applications: A Case Study. In SC '05: Proceedings of the 2005 ACM/IEEE conference on Supercomputing, page 27, Washington, DC, USA, 2005. IEEE Computer Society.
[19]
M. Wetterhall. Hadamard Transform Time-of Flight Mass Spectrometry. Technical report, Stanford University, 2001.

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  • (2009)Design and implementation of a high‐performance CCA event serviceConcurrency and Computation: Practice and Experience10.1002/cpe.138221:9(1159-1179)Online publication date: 13-Feb-2009

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cover image ACM Conferences
HPRCTA '07: Proceedings of the 1st international workshop on High-performance reconfigurable computing technology and applications: held in conjunction with SC07
November 2007
54 pages
ISBN:9781595938947
DOI:10.1145/1328554
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Published: 11 November 2007

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  • (2009)Design and implementation of a high‐performance CCA event serviceConcurrency and Computation: Practice and Experience10.1002/cpe.138221:9(1159-1179)Online publication date: 13-Feb-2009

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