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Applications of the PROPHET system in molecular pharmacology: structure-activity relationships in monoamine oxidase inhibitors

Published: 06 May 1974 Publication History

Abstract

Understanding the molecular bases of drug action and drug-related phenomena in man and other animal species is a primary concern of the Department of Pharmacology, Mt. Sinai School of Medicine. Toward this end, a diverse array of laboratory and theoretical investigations involving a wealth of analytical and computational tools are in progress. This paper describes one of these areas of study, namely, structure-activity relationships in inhibitors of the enzyme monoamine oxidase, and illustrates how the PROPHET System is employed in the organization, manipulation, and analysis of research results.

References

[1]
Biel, J. H., A. Horita, and A. E. Drukker, "Psychopharmacological Agents," Medicinal Chemistry Series, Vol. 4-I (Gordon, ed.), Academic, New York, 1964, pp. 359--443.
[2]
McDaniel, D. H. and H. C. Brown, J. Orgn. Chem. 23, pp. 420--427, 1958.
[3]
Hansch, C., A. Leo, S. H. Unger, K. H. Kim, D. Nikaitani, and E. J. Lien, J. Med. Chem. 16, pp. 1207--1216, 1973.
[4]
Leo, A., C. Hansch, and D. Elkins, Chem. Rev. 71, pp. 525--616, 1971.
[5]
Pople, J. A. and G. A. Segal, J. Chem. Phys. 44, pp. 3289--3296, 1966.
[6]
Fujita, T., J. Med. Chem. 16, pp. 923--930, 1973.
[7]
Zirkle, C. L., C. Kaiser, D. H. Tedeschi, R. F. Tedeschi, and A. J. Burger, Med. Pharm. Chem. 5, pp. 1265--1284, 1963.

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  1. Applications of the PROPHET system in molecular pharmacology: structure-activity relationships in monoamine oxidase inhibitors

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      cover image ACM Other conferences
      AFIPS '74: Proceedings of the May 6-10, 1974, national computer conference and exposition
      May 1974
      1083 pages
      ISBN:9781450379205
      DOI:10.1145/1500175
      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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      Association for Computing Machinery

      New York, NY, United States

      Publication History

      Published: 06 May 1974

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