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Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

Published: 12 June 2009 Publication History

Abstract

In response to genome stresses, cell can trigger the self-defensive mechanisms by regulating the vital genes and their complicated signal pathways. To illustrate the celluar response in fighting against DNA damage under radiotherapy, a feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of Double Strand Breaks(DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as feedback-control to ion radiation (IR) dose are presented.

References

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G.W.A. Tjebbes, P.A. Kreijveldb, 2002, P53 tumor suppressor gene mutations in laryngeal cancer and in recurrent disease following radiation therapy, Oral Oncology, vol.38, pp.296--300.
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M.S. Lindstrom, K.G. Wiman, 2003, Myc and E2F1 induce P53 through p14ARF-independent mechanisms in human fibroblasts, Oncogene, vol.22, pp.4993--5005.
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Siim. Pauklin, Arnold. Kristjuhan, 2005, Toivo. Maimets et al., "ARF and ATM/ATR cooperate in P53-mediated apoptosis upon oncogenic stress", Biochemical and Biophysical Research Communications, vol.334, 386--394.
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Lan. Ma, John. Wagner, 2005, "A plausible model for the digital response of P53 to DNA damage", PNAS, vol.2, no.40, pp.14266--14271.
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Qi, Jin-Peng; Shao, Shi-Huang, 2007, Modeling and simulation of P53 gene regulatory networks under DNA damage, Journal of System Simulation, vol.19(14),pp.3321--3323.
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J.-P. Qi, S.-H. Shao, D.-D. Li, and G.-P. Zhou, 2007, A dynamic model for the P53 stress response networks under ion radiation, Amino Acids, vol.33 (1),pp.75--83.
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  1. Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

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    cover image ACM Conferences
    GEC '09: Proceedings of the first ACM/SIGEVO Summit on Genetic and Evolutionary Computation
    June 2009
    1112 pages
    ISBN:9781605583266
    DOI:10.1145/1543834

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    Association for Computing Machinery

    New York, NY, United States

    Publication History

    Published: 12 June 2009

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    Author Tags

    1. DNA damage
    2. P53
    3. cellular networks; modeling
    4. radiotherapy

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