Jinpeng Qi
ABSTRACT
In response to genome stresses, cell can trigger the self-defensive mechanisms by regulating the vital genes and their complicated signal pathways. To illustrate the celluar response in fighting against DNA damage under radiotherapy, a feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of Double Strand Breaks(DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as feedback-control to ion radiation (IR) dose are presented.
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Index Terms
- Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy
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Plausible model of feedback-control for cellular response based on gene regulatory networks under radiotherapy
ICIC'09: Proceedings of the 5th international conference on Emerging intelligent computing technology and applicationsIn response to genome stresses, cell can trigger its self-defensive mechanism by regulating the vital genes and their complicated signal pathways. To illustrate the cellular response DNA damage under radiotherapy, a plausible feedback-control model of ...
A plausible model for cellular self-defense mechanisms in response to continuous ion radiation(IR) under radiotherapy
ICIC'09: Proceedings of the 5th international conference on Emerging intelligent computing technology and applicationsRadiotherapy can induce DNA damage into cells and trigger the cell cycle arrest and cell apoptosis by regulating the vital genes and their signal pathways. To illustrate the cellular self-defense mechanisms in fighting against genome stresses under ...
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