Dynamic modeling of muscle-driven anatomical structures provides a means to better understand complex biomechanical systems. A rich application area for such models is the human orofacial anatomy, shown in Figure 1A, which is involved in a wide range of important functions including chewing, swallowing, breathing, and speaking. Comprehensive models of orofacial biomechanics will enhance our limited understanding of dysfunctions such as obstructive sleep apnea, swallowing disorders, and post-surgical deficits, such as reconstructive jaw surgery (Figure 1D).