skip to main content
10.1145/1854776.1854862acmconferencesArticle/Chapter ViewAbstractPublication PagesbcbConference Proceedingsconference-collections
research-article

Pulmonary artery smooth muscle responses to KCl under normoxic and hypoxic conditions studied by means of a spatial network model

Published: 02 August 2010 Publication History

Abstract

We study contractile responses and Ca2+ signalization in pulmonary artery smooth muscle cells. Experimental results indicate that the contraction responses to KCl under normoxic conditions are not affected by the contribution of gap junction blockers. On the other side, under hypoxic condition, where the contraction occurs at lower concentrations of KCl, the application of gap junction blockers suppresses the hypersensitive response. In order to provide a theoretical explanation for the observed phenomenon we develop a network model of the pulmonary artery. Our results indicate that in tissues from normoxic rats the cells are connected in an efficient network that has features of a complex network, whereas the cells in tissues from hypoxic animals form a network similar to a random geometric network. Apparently, the morphological changes of the pulmonary vasculature that are induced by hypoxic conditions also entail modifications in the topology of intercellular communication pathways.

References

[1]
Albert, R. and Barabási, A.-L. 2002. Statistical mechanics of compex networks. Rev. Mod. Phys. 74, 47--97.
[2]
Billaud, M., Marthan, R., Savineau, J. P. and Guibert, C. 2009. Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications. PLoS One 4, e6432.
[3]
Guibert, C., Marthan, R. and Savineau, J. P. 2004. 5-HT induces an arachidonic acid-sensitive calcium influx in rat small intrapulmonary artery. Am. J. Physiol. Lung. Cell. Mol. Physiol. 286, L1228--1236.
[4]
Parthimos, D., Edwards, D. H. and Griffith, T. M. 1999. Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators. Am. J. Physiol. Heart Circ. Physiol. 277, H1119--H1144.
[5]
Platoshyn, O., Remillard, C. V., Fantozzi, I., Mandegar, M., Sison, T. T., Zhang, S., Burg, E. and Yuan, J. X.-J. 2004. Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells, Am. J. Physiol. Lung. Cell. Mol. Physiol. 287, L226--L238.
[6]
Rodat, L., Savineau, J. P., Marthan, R. and Guibert, C. 2007. Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteries. Pflugers Arch 454, 41--51.

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Conferences
BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology
August 2010
705 pages
ISBN:9781450304382
DOI:10.1145/1854776
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

Sponsors

Publisher

Association for Computing Machinery

New York, NY, United States

Publication History

Published: 02 August 2010

Permissions

Request permissions for this article.

Check for updates

Author Tags

  1. calcium signaling
  2. chronic hypoxia
  3. complex network
  4. intrapulmonary arteries
  5. smooth muscle cells

Qualifiers

  • Research-article

Conference

BCB'10
Sponsor:

Acceptance Rates

Overall Acceptance Rate 254 of 885 submissions, 29%

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • 0
    Total Citations
  • 61
    Total Downloads
  • Downloads (Last 12 months)1
  • Downloads (Last 6 weeks)0
Reflects downloads up to 17 Jan 2025

Other Metrics

Citations

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

Media

Figures

Other

Tables

Share

Share

Share this Publication link

Share on social media