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Alzheimer's disease target selection: a data integration approach

Published: 02 August 2010 Publication History

Abstract

The integration of information across carefully selected species and experimental platforms is emerging as a powerful technique for selecting potential therapeutic targets for human diseases: this method enables a holistic view of the experimental landscape and hence of the disease. Alzheimer's disease (AD), which affects an estimated 5.3 million patients, is characterized by Amyloid-β plaques and neurofibril tangles made up of Tau aggregated protein in different regions of the brain. Current therapies produce only a minimal impact on the progression of the disease. Here we present a method that integrates gene expression profiling data from an AD mouse model (Tg4510) with in vitro cell assays plus gene expression data from different brain regions from several normal human brains as well as those displaying different degrees of AD pathology to provide a mechanism for target selection. Pathway analysis is used to put the targets into biological context, including established signaling cascades, and explore other potential novel targets. A target scoring and tracking mechanism is used to assist in new target selection and monitor the progress of the targets through several experimental validation assays.

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  1. Alzheimer's disease target selection: a data integration approach

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        cover image ACM Conferences
        BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology
        August 2010
        705 pages
        ISBN:9781450304382
        DOI:10.1145/1854776
        Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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        Published: 02 August 2010

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        Author Tags

        1. Alzheimer's disease
        2. ApoE
        3. Tg4510
        4. amyloid β
        5. data integration
        6. expression profiling
        7. scoring matrix
        8. siRNA
        9. target tracking
        10. tau protein

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