Whole-genome immunoinformatic analysis of Mycobacterium tuberculosis towards large scale identification of immunodominant CD8 epitopes
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Identification and evaluation of immunogenic MHC-I and MHC-II binding peptides from Mycobacterium tuberculosis
AbstractDue to several limitations of the only available BCG vaccine, to generate adequate protective immune responses, it is important to develop potent and cost-effective vaccines against tuberculosis (TB). In this study, we have used an immune-...
Highlights- 5 proteins namely ECCB1, ECCD1, ECCE1, TB 31.7 and MyCP1 were predicted as the most antigenic proteins.
- Best predicted peptides were found to be present in the MtbTB31.7 (Rv2623).
- Simulation studies showed significantly less ...
“Identification of alkaloid compounds as potent inhibitors of Mycobacterium tuberculosis NadD using computational strategies”
AbstractMycobacterium tuberculosis is leading cause of death worldwide. NAD participates in a host of redox reactions in energy landscape of organisms. Several studies implicate surrogate energy pathways involving NAD pools as important in survival of ...
Graphical abstractCheminformatics research methodology template for forecasting possible anti-tubercular drugs. The Selleckchem Database's 20210731-L7900-Alkaloid-Compound-Library were evaluated against the mtbNadD enzyme. A total of 30 hits were chosen ...
Highlights- Secondary energy pathways are attractive targets in mycobacteria to design novel drug leads.
- Ten alkaloids are proposed as potential hits against the MtbNadD enzyme using in silico docking and simulation analysis.
- Hydroprotopine ...
Virtual screening for the identification of novel inhibitors of Mycobacterium tuberculosis cell wall synthesis
BackgroundTuberculosis remains one of the deadliest infectious diseases in humans. It has caused more than 100 million deaths since its discovery in 1882. Currently, more than 5 million people are infected with TB bacterium each year. The cell wall of ...
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- General Chairs:
- Aidong Zhang,
- Mark Borodovsky,
- Program Chairs:
- Gultekin Ozsoyoglu,
- Armin Mikler
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Association for Computing Machinery
New York, NY, United States
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