ABSTRACT
The large scale application of ICT-based assistive environment technologies for the home care of elderly and disabled people is going to generate huge numbers of signals transmitted from homes to local health centers or hospitals in order to be monitored by medical personnel. This task is going to be of critical importance and at the same time - if manually performed - quite demanding for specialized human resources and costly. In order to perform it in a cost-efficient manner it is necessary to develop mechanisms and methods for automated screening of these signals in order to identify abnormal ones that require some action to be taken. This paper proposes a method for automatic screening of heart sound signals, which are the most widely acquired signals from the human body for diagnostic purposes in both the 'traditional' medicine and the emerging ICT-based assistive environments. It is based on a novel Markov Chain Monte Carlo (MCMC) Bayesian Inference approach, which estimates conditional probability distributions in structures obtained from a Tree-Augmented Naïve Bayes (TAN) algorithm. The proposed approach has been applied and validated in a difficult heterogeneous dataset of 198 heart sound signals, which comes from both healthy medical cases and unhealthy ones having Aortic Stenosis, Mitral Regurgitation, Aortic Regurgitation or Mitral Stenosis. The proposed approach achieved a good performance in this difficult screening problem, which is higher than other widely used alternative classifiers, showing great potential for contributing to a cost-effective large scale application of ICT-based assistive environment technologies.
- Friedman, N., Koller, D.: Being Bayesian about network structure: A Bayesian approach to structure discovery in Bayesian networks. Machine Learning 50, 95--126 (2003)Google ScholarCross Ref
- Heckerman, D.: A Tutorial on Learning with Bayesian Networks. In: Jordan, M. (ed.) Learning in Graphical Models. MIT Press, Cambridge (1999) Google ScholarDigital Library
- Pearl, J.: Causality: Models, Reasoning and Inference. Cambridge University Press, Cambridge (2000) Google ScholarDigital Library
- Pearl, J. Probabilistic reasoning in Intelligent Systems: networks for plausible inference. Morgan Kaufmann (1988) Google ScholarDigital Library
- Stasis, A., Loukis, E., Pavlopoulos, S., Koutsouris, D.: A multiple decision trees architecture for medical diagnosis: The differentiation of opening snap, second heart sound split and third heart sound. Computational Management Science, Springer Verlag, Autumn 2004, pp. 245--274.Google Scholar
- Cathers I.: Neural network assisted cardiac auscultation. Artificial Intelligence in Medicine, February 1995, Volume 7, Issue 1, pp. 53--66Google Scholar
- Wu C. H., Lo C. W., Wang J. F.: Computer-aided analysis of classification of heart sounds based on neural networks and time analysis. In Proceedings of the IEEE International Conference on Acoustics, Speech and Signals Processing (ICASSP) 1995, 5, pp. 4355--3458.Google Scholar
- Wu C. H.: On the analysis and classification of heart sounds based on segmental Bayesian networks and time analysis. Journal of the Chinese Institute of Electrical Engineering - Transactions of the Chinese Institute of Engineers, Series E November 1997, 4(4), pp. 343--350.Google Scholar
- Leung T. S., White P. R., Collis W. B., Brown E., Salmon A. P.: Classification of heart sounds using time-frequency method and artificial neural networks. In Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2000, 2:988--991.Google ScholarCross Ref
- White PR, Collis WB, Salmon AP: Analysing heart murmurs using time-frequency methods. In Proceeding of the IEEE-SP International Symposium Time-Frequency and Time-Scale Analysis June 1996, pp. 385--388.Google ScholarCross Ref
- Nakamitsu T., Shino H., Kotani T., Yana K., Harada K., Sudoh J., Harasawa E., Itoh H.: Detection and classification of systolic murmur using a neural network. In Proceeding of the 15th IEEE Southern Biomedical Engineering Conference March 1996, pp. 365--366.Google ScholarCross Ref
- Leung T. S., White P. R., Collis W. B., Brown E., Salmon A. P.: Analysingpaediatric heart murmurs with discriminant analysis. In Proceedings of the 19th Annual conference of the IEEE Engineering in Medicine and Biology Society, Hong Kong 1998, pp. 1628--1631.Google ScholarCross Ref
- Leung T. S., White P. R., Collis W. B., Brown E., Salmon A. P.: Characterisation of paediatric heart murmurs using self-organising map. In Proceedings of the Joint Meeting of the BMES & IEEE Engineering in Medicine and Biology Society, 1999: 926.Google Scholar
- Noponen A. L., Lukkarinen S., Angerla A., Sikio K., Sepponen R.: How to recognize the innocent vibratory murmur. Computers in Cardiology 2000, pp. 561--564.Google Scholar
- DeGroff C., Bhatikar S., Mahajan R.: A classifier based on the artificial neural network approach for cardiologic auscultation in pediatrics. Artificial Intelligence in Medicine 2005, 33, pp. 251--260. Google ScholarDigital Library
- De Vos J. P., Blanckenberg M. M. Automated pediatric cardiac auscultation. IEEE Transactions on Biomedical Engineering February 2007, 54(2), pp. 244--252.Google ScholarCross Ref
- Akay M.: Noninvasive diagnosis of coronary artery disease using a neural network algorithm. Biological Cybernetics 1992, 67, pp. 361--367. Google ScholarDigital Library
- Akay Y., Akay M., Welkowitz W., Kostis J.: Noninvasive detection of coronary artery disease. IEEE Engineering in Medicine and Biology 1994, 13(5), pp. 761--764.Google Scholar
- Bahadirlar Y., OzcanGulcur H., Aytekin S., Gulmez U.: Acoustical detection of coronary artery disease. In Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society November 1994, 2, pp. 1278--1279.Google ScholarCross Ref
- Xuesong Y., Qiang C. Yuquan C.: Noninvasive detection of coronary artery disease based on heart sounds. In Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 29 Oct. -- 1 Nov.1998, 3, pp. 1546--1548.Google Scholar
- Tateishi O.: Clinical significance of the acoustic detection of coronary artery stenosis. Journal of Cardiology November 2001, 38(5), pp. 255--262.Google Scholar
- Nygaard H., Thuesen L., Hasenkam J. M., Pedersen E. M., Paulsen P. K.: Assessing the severity of aortic valve stenosis by spectral analysis of cardiac murmurs (spectral vibrocardiography). Part I: Technical aspects. Journal of Heart Valve Disease July 1993, 2(4), pp. 454--67.Google Scholar
- Hebden J. E, Torry J. N: Identification of Aortic Stenosis and Mitral Regurgitation by Heart Sound Analysis. Computers in Cardiology 1997, 24, pp. 109--112.Google Scholar
- Brusco M., Nazeran H.: Development of an Intelligent PDA-based Wearable Digital Phonocardiograph. In Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference 2005, 4, pp. 3506--9.Google ScholarCross Ref
- Herold J., Schroeder R., Nasticzky F., Baier V., Mix A., Huebner T., Voss A.: Diagnosing aortic valve stenosis by correlation analysis of wavelet filtered heart sounds. Medical and Biological Engineering and Computing 2005, 43, pp. 451--456.Google Scholar
- Voss A., Mix A., Huebner T.: Diagnosing Aortic Valve Stenosis by Parameter Extraction of Heart Sound Signals. Annals of Biomedical Engineering September 2005, 33(9), pp. 1167--1174.Google ScholarCross Ref
- Higuchi K., Sato K., Makuuchi H., Furuse A., Takamoto S., Takeda H. Automated diagnosis of heart disease in patients with heart murmurs: application of a neural network technique. Journal of Medical Engineering and Technology 2006 March-April, 30(2), pp. 61--68.Google Scholar
- Ahlstrom C., Hult P., Rask P., Karlsson J. E., Nylander E., Dahlstrom U., Ask P. Feature extraction for systolic heart murmur classification. Annals of Biomedical Engineering 2006 November, 34(11), pp. 1666--77.Google Scholar
- Pavlopoulos S., Stasis A., Loukis E.: A decision tree -- based method for the differential diagnosis of Aortic Stenosis from Mitral Regurgitation using heart sounds. BioMedical Engineering OnLine, June 2004.Google Scholar
- Maglogiannis, I., Loukis, E., Zafiropoulos, E., Stasis, A., Support Vectors Machine based Identification of Heart Valve Diseases Using Heart Sounds. Computer Methods and Programs in Biomedicine, Volume 95, Issue 1, pp. 47--61. (2009) Google ScholarDigital Library
- Chauhan, S., Wang, P., Lim, C. S., Anantharaman, V.: A Computer Aided MFCC based HMM system for automatic auscultation. Computers in Biology and Medicine, Volume 38(2), pp. 221--233 (2008). Google ScholarDigital Library
- Ram, R., Chetty, M.: Constraint Minimization for Efficient Modeling of Gene Regulatory Network. In: Chetty, M., Ngom, A., Ahmad, S. (eds.) PRIB 2008. LNCS (LNBI), vol. 5265, pp. 201--213. Springer, Heidelberg (2008) Google ScholarDigital Library
- Liu, J. S.: Monte Carlo Strategies in Scientific Computing. Springer, Heidelberg (2001)Google Scholar
- Lunn, A, Thomas, G, Best, H, Spiegelhalter, D. WinBUGS -- A Bayesian modeling framework: Concepts, structure, and extensibility, Statistics and Computing 10, 325--337 (2000) Google ScholarDigital Library
- Rapid-Miner, A software for Data Mining Tasks, www.rapidi.comGoogle Scholar
Index Terms
- MCMC Bayesian inference for heart sounds screening in assistive environments
Recommendations
Heart sound screening in real-time assistive environments through MCMC Bayesian data mining
Emerging pervasive assistive environment applications for remote home healthcare monitoring of the elderly, disabled and also patients with various chronic diseases generate massive amounts of sensor signal data, which are transmitted from numerous ...
Heart murmurs identification using random forests in assistive environments
PETRA '10: Proceedings of the 3rd International Conference on PErvasive Technologies Related to Assistive EnvironmentsThe aging population in many countries, in combination with high government deficits and financial resources limitations, necessitates new methods for the home care of the elderly at reasonable costs based on the exploitation of modern information and ...
Simulation-based Bayesian inference for epidemic models
A powerful and flexible method for fitting dynamic models to missing and censored data is to use the Bayesian paradigm via data-augmented Markov chain Monte Carlo (DA-MCMC). This samples from the joint posterior for the parameters and missing data, but ...
Comments