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Design of a parallel immune algorithm based on the germinal center reaction

Published:06 July 2013Publication History

ABSTRACT

Artificial Immune algorithms are relatively new randomized meta-heuristics and not a lot of work has been done on parallel immune algorithms yet. Most of these implementations use some version of the first generation artificial immune algorithms. In this research a novel parallel artificial immune algorithm for optimization is proposed based on cutting edge research in the study of germinal center reaction. This parallelism of the algorithm is inherent in the system as a whole, which is different than other parallel implementations of nature inspired algorithms, where several instances of the algorithm is run multiple times to exploit parallel architecture of computers. This system is being developed with input from immunologist and incorporates new ideas which have not been explored before. Some preliminary results are presented which hint that it could perform better than the evolutionary algorithm ((1+1)EA), with which it is compared. The algorithm is not limited to optimization and in the future the research will look into other application areas. Also limitations, improvements and applications where it excels, will be explored in the research.

References

  1. H. Bersini. The immune recruitment mechanism. A Selective Evolutionary Strategy, Proc. 4th ICGA, 1991, 1991.Google ScholarGoogle Scholar
  2. H. Bersini. Immune network and adaptive control. Varela and Bourgine, 2332:217--226, 1992.Google ScholarGoogle Scholar
  3. H. Bersini and F. Varela. Hints for adaptive problem solving gleaned from immune networks. In H.-P. Schwefel and R. Männer, editors, Parallel Problem Solving from Nature, volume 496 of Lecture Notes in Computer Science, pages 343--354. Springer Berlin Heidelberg, 1991. Google ScholarGoogle ScholarDigital LibraryDigital Library
  4. D. Dasgupta. Advances in artificial immune systems. Computational Intelligence Magazine, IEEE, 1(4):40--49, Nov. 2006. Google ScholarGoogle ScholarDigital LibraryDigital Library
  5. D. Dasgupta, S. Yu, and N. Majumdar. Mila - multilevel immune learning algorithm. In Genetic and Evolutionary Computation GECCO 2003, pages 201--201. Springer, 2003. Google ScholarGoogle ScholarDigital LibraryDigital Library
  6. L. N. De Castro and J. Timmis. Artificial immune systems: a new computational intelligence approach. Springer, 2002. Google ScholarGoogle ScholarDigital LibraryDigital Library
  7. L. N. De Castro and F. J. Von Zuben. Artificial immune systems: Part ii - a survey of applications. Department of Computer Engineering and Industrial, Tech. Rep, 2000.Google ScholarGoogle Scholar
  8. L. N. de Castro and F. J. Von Zuben. ainet: an artificial immune network for data analysis. Data mining: a heuristic approach, 12:231--259, 2001.Google ScholarGoogle Scholar
  9. L. N. De Castro and F. J. Von Zuben. Learning and optimization using the clonal selection principle. Evolutionary Computation, IEEE Transactions on, 6(3):239--251, 2002. Google ScholarGoogle ScholarDigital LibraryDigital Library
  10. J. D. Farmer, N. H. Packard, and A. S. Perelson. The immune system, adaptation, and machine learning. Physica D: Nonlinear Phenomena, 22(1):187--204, 1986. Google ScholarGoogle ScholarDigital LibraryDigital Library
  11. S. Forrest, A. S. Perelson, L. Allen, and R. Cherukuri. Self-nonself discrimination in a computer. In Research in Security and Privacy, 1994. Proceedings., 1994 IEEE Computer Society Symposium on, pages 202--212. Ieee, 1994. Google ScholarGoogle ScholarDigital LibraryDigital Library
  12. J. Greensmith, U. Aickelin, and S. Cayzer. Introducing dendritic cells as a novel immune-inspired algorithm for anomaly detection. In ICARIS, pages 153--167, 2005. Google ScholarGoogle ScholarDigital LibraryDigital Library
  13. G. W. Hoffmann. A neural network model based on the analogy with the immune system. Journal of Theoretical Biology, 122(1):33--67, 1986.Google ScholarGoogle ScholarCross RefCross Ref
  14. J. Kelsey and J. Timmis. Immune Inspired Somatic Contiguous Hypermutation for Function Optimisation. In E. C.-P. et al, editor, Genetic and Evolutionary Computation Conference - GECCO 2003, volume 2723 of Lecture Notes in Computer Science, Chicago. USA., July 2003. Springer-Verlag. Google ScholarGoogle ScholarDigital LibraryDigital Library
  15. T. B. Kepler and A. S. Perelson. Cyclic re-entry of germinal center b cells and the efficiency of affinity maturation. Immunology today, 14(8):412--415, 1993.Google ScholarGoogle ScholarCross RefCross Ref
  16. F. Liu, Q. Wang, and X. Gao. Survey of artificial immune system. In Systems and Control in Aerospace and Astronautics, 2006. ISSCAA 2006. 1st International Symposium on, pages 5--pp. IEEE, 2006.Google ScholarGoogle Scholar
  17. K. M. Murphy, P. Travers, and M. Walport. Janeways immunology. Garland science, 2008.Google ScholarGoogle Scholar
  18. J. Twycross, U. Aickelin, and A. M. Whitbrook. Detecting anomalous process behaviour using second generation artificial immune systems. IJUC, 6(3-4):301--326, 2010.Google ScholarGoogle Scholar
  19. C. Van Hoyweghen, D. E. Goldberg, and B. Naudts. From twomax to the ising model: Easy and hard symmetrical problems. generations, 11(01):10, 2001.Google ScholarGoogle Scholar
  20. X. Wang, X. Gao, and S. Ovaska. Artificial immune optimization methods and applications-a survey. In Systems, Man and Cybernetics, 2004 IEEE International Conference on, volume 4, pages 3415--3420. IEEE, 2004.Google ScholarGoogle Scholar
  21. T. Zenz, D. Mertens, R. Küppers, H. Döhner, and S. Stilgenbauer. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nature Reviews Cancer, 10(1):37--50, 2009.Google ScholarGoogle ScholarCross RefCross Ref
  22. Y. Zhang, M. Meyer-Hermann, L. A. George, M. T. Figge, M. Khan, M. Goodall, S. P. Young, A. Reynolds, F. Falciani, A. Waisman, et al. Germinal center b cells govern their own fate via antibody feedback. The Journal of experimental medicine, 210(3):457--464, 2013.Google ScholarGoogle Scholar

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        • Published in

          cover image ACM Conferences
          GECCO '13 Companion: Proceedings of the 15th annual conference companion on Genetic and evolutionary computation
          July 2013
          1798 pages
          ISBN:9781450319645
          DOI:10.1145/2464576
          • Editor:
          • Christian Blum,
          • General Chair:
          • Enrique Alba

          Copyright © 2013 ACM

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          Publication History

          • Published: 6 July 2013

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