Shang-Tsung Yu
ABSTRACT
Nowadays, electrowetting-on-dielectric (EWOD) chips have become the most popular actuator for droplet-based digital microfluidic biochips. As the complexity of biochemical assay increases, the chip-level design of EWOD chips which integrates electrode addressing and wire routing are widely adopted. Furthermore, to finish many time-sensitive bioassays such as incubation and emerging flash chemistry in a specific time, a high-frequency EWOD is used to satisfy the demand. However, the reliability of the EWOD chip degrades due to the contact angle reduction problem incurred by huge number of switching times of an electrode. Thus, the reliability issue, electrode addressing, and wire routing problem should be considered together in the chip-level design of an EWOD chips. In this paper, a graph-based chip-level design algorithm is presented. By setting the switching-time constraint, the number of switching times can be limited to minimize the impact of contact angle reductions problem. Also, a progressive addressing and routing approach is proposed to overcome the challenge of complex wire routing problem. Experimental results show that the influence of contact angle reduction problem can be effectively minimized by proposed algorithm. A reliable chip-level design with feasible wire routing solution can be generated with number of pins are satisfied.
- J.-W. Chang, T.-W. Huang, and T.-Y. Ho, "An ILP-based obstacle-avoiding Routing algorithm for pin-constrained EWOD chips," Proc. IEEE/ACM ASPDAC, pp. 67--72, 2012.Google Scholar
- K. Chakrabarty,"Towards fault-tolerant digital microfluidic lab-on-chip:defects, fault modeling, testing, and reconfiguration," Proc. IEEE ICBCS, pp. 329--332, 2008.Google ScholarCross Ref
- R. B. Fair,"Digital microfluidics: is a true lab-on-a-chip possible?," Microfluidics and Nanofluidics, vol. 3, no. 3, pp. 245--281, 2007.Google ScholarCross Ref
- Shih-Kang Fan, Tsung-Han Hsieh and Di-Yu Lin,"General digital microfluidic platform manipulating dieletric andconductive droplets by dielectrophoresis and electrowetting," Lab on chip, pp. 1236--1242, 2009Google ScholarCross Ref
- J. Gong and C. J. Kim,"Direct-referencing two-dimensional-array digital microfluidicsusing multilayer printed circuit board," IEEE J. MEMS, no. 2, pp. 257--264, 2008.Google ScholarCross Ref
- T.-Y. Ho, J. Zeng, and K. Chakrabarty,"Digital microfluidic biochips: A vision for functional diversity and more than Moore," IEEE/ACM ICCAD, pp. 578--585, 2010. Google ScholarDigital Library
- T.-W. Huang, S.-Y. Yeh, and T.-Y. Ho,"A network-flow based pin-count aware routing algorithmfor broadcast electrode-addressing EWOD chips," Proc. IEEE/ACM ICCAD, pp. 425--431, 2010. Google ScholarDigital Library
- T.-W. Huang, H.-Y. Su and T.-Y. Ho,"Progressive Network-Flow Based Power-Aware BroadcastAddressing for Pin-Constrained Digital Microfluidic Biochips," Proc. IEEE/ACM DAC, pp. 741--746, 2011. Google ScholarDigital Library
- T.-W. Huang, K. Chakrabarty, and T.-Y. Ho,"Reliability-oriented broadcast electrode-addressing forpin-constrained digital microfluidic biochips," Proc. IEEE/ACM ICCAD, pp. 448--455, 2011. Google ScholarDigital Library
- L. Huang, B. Koo, and C. J. Kim,"Evaluation of anodic Ta2 O5 as the dielectric layer for EWOD devices," IEEE MEMS, pp. 428--431, 2012.Google Scholar
- C. C.-Y. Lin and Y.-W. Chang,"ILP-based pin-count aware design methodology for microfluidic biochips," Proc. ACM/IEEE DAC, pp. 258--263, 2009. Google ScholarDigital Library
- Y. Luo, K. Chakrabarty, and T.-Y. Ho,"Design of cyberphysical digital microfluidic biochipsunder Completion-Time Uncertainties in Fluidic Operations," Proc. ACM/IEEE DAC, 2013 Google ScholarDigital Library
- P. Paik, V. Pamula, and R. Fair,"Rapid droplet mixers for digital microfluidic systems," Lab on a Chip, vol.3, pp. 253--259, 2003.Google ScholarCross Ref
- M. G. Pollack, A. D. Shenderov, and R. B. Fair,"Electrowetting-based actuation of droplets for integrated microfluidics," Lab on chip, pp. 96--101, 2002.Google ScholarCross Ref
- J. H. Song, R. Evans, Y. Y. Lin, B. N. Hsu, and R. B. Fair,"A scaling model for electrowetting-on-dielectric microfluidic actuators," Microfluidics and Nanofluidics, pp. 75--89, 2009.Google ScholarCross Ref
- F. Su, K. Chakrabarty, and R. B. Fair,"Microfluidics based biochips:technology issues, implementation platforms, and design-automation challenges," IEEE Trans. on CAD, pp. 211--223, 2006. Google ScholarDigital Library
- T. Xu and K. Chakrabarty,"Broadcast electrode-addressing forpin-constrained multi-functional digital microfluidic biochips," Proc. ACM/IEEE DAC, pp. 173--178, 2008. Google ScholarDigital Library
- S.-H. Yeh, J.-W. Chang, T.-W. Huang, T.-Y. Ho,"Voltage-aware chip-level design forreliability-driven pin-constrained EWOD chips," Proc. IEEE/ACM ICCAD, pp. 353--360, 2012. Google ScholarDigital Library
- T. Yan and M. D. F. Wong,"A correct network flow model for escaperouting," Proc. ACM/IEEE DAC, pp. 332--335, 2009. Google ScholarDigital Library
- L. Young,"Anodic oxides films,"New York, NY: Academic Press Inc., 1961.Google Scholar
- Y. Zhao and K. Chakrabarty,"Co-optimization of droplet routing and pin assignmentin disposable digital microfluidic biochips," Proc. ACM ISPD, pp. 69--76, 2011. Google ScholarDigital Library
Index Terms
- Reliability-driven chip-level design for high-frequency digital microfluidic biochips
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