Rotem Golan
ABSTRACT
Understanding how organisms develop from a single cell into a functioning multicellular organism is one of the key questions in developmental biology. Research in this area goes back decades ago, but only recently have improvements in technology allowed biologists to achieve experimental results that are more quantitative and precise. Here, we show how large biological datasets can be used to learn a model for predicting the patterns of gene expression in Drosophila melanogaster (fruit fly) throughout embryogenesis. We also explore the possibility of considering spatial information in order to achieve unique patterns of gene expression in different regions along the anterior-posterior (head-tail) axis of the egg. We then demonstrate how the resulting model can be used to (1) classify these regions into the various segments of the fly, and (2) to conduct a virtual gene knockout experiment. Our learning algorithm is based on a model that has biological meaning, which indicates that its structure and parameters have their correspondence in biology.
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Index Terms
- Predicting patterns of gene expression during drosophila embryogenesis
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