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A System Dynamics Model for Chemotherapy

Published: 09 May 2016 Publication History

Abstract

Chemotherapy is one of the most common approaches in cancer treatment. The problem with chemotherapy is that it does not only kill the cancerous cells, but the therapy affects badly the healthy cells as well. Accumulation of chemotherapy drugs with repeated doses in the patient's body leads to increasing toxicity in the whole body. This paper develops a general system dynamics model which clarifies the different factors affecting the treatment plans such as number of cancerous cells, drug accumulation, and toxicity. A stock and flow diagram is constructed to show the interaction of the system variables with each other. A simulation model using iT hink software is used. The simulation results show a decreasing trend of the number of cancerous cells with repeated chemotherapy doses with time. On the other hand, the toxicity increases with time. Finally, sensitivity analysis is conducted to show the effect of doses cancellation and delay on the treatment efficacy. The results show that the model is more sensitive to doses cancellation than doses delay, thus cancelling doses is more critical on the patient's health than doses delaying.

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M. Heshmat and A. Eltawil, "Solution Methods for the Planning and Scheduling Problems of Outpatient Chemotherapy Units", International Conference on Industrial Engineering and Engineering Management (IEEE IEEM), Singapore, pp. 1318--1322, December 6-9, 2015.

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  • (2022)Clustering and Stochastic Simulation Optimization for Outpatient Chemotherapy Appointment Planning and SchedulingInternational Journal of Environmental Research and Public Health10.3390/ijerph19231553919:23(15539)Online publication date: 23-Nov-2022

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cover image ACM Other conferences
INFOS '16: Proceedings of the 10th International Conference on Informatics and Systems
May 2016
347 pages
ISBN:9781450340625
DOI:10.1145/2908446
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Association for Computing Machinery

New York, NY, United States

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Published: 09 May 2016

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Author Tags

  1. Chemotherapy
  2. Simulation
  3. Stock and Flow
  4. System Dynamics

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Cited By

View all
  • (2022)Clustering and Stochastic Simulation Optimization for Outpatient Chemotherapy Appointment Planning and SchedulingInternational Journal of Environmental Research and Public Health10.3390/ijerph19231553919:23(15539)Online publication date: 23-Nov-2022

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