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Kinetic and Affinity Constraints on Reactions Between Antihapten Antibodies and Nonpeptidic B-Cell Epitopes: Implications for Predicting Antibody-Mediated Modulation of Pharmacokinetics and Pharmacodynamics

Published: 02 October 2016 Publication History

Abstract

For antihapten antibody-mediated modulation of pharmacodynamics and pharmacokinetics, B-cell epitope prediction may be formulated as estimation of quantities describing antibody-hapten affinity, reaction kinetics (for noncatalytic or even catalytic binding) and, in turn, parameters such as drug concentration and half-life.

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  1. Kinetic and Affinity Constraints on Reactions Between Antihapten Antibodies and Nonpeptidic B-Cell Epitopes: Implications for Predicting Antibody-Mediated Modulation of Pharmacokinetics and Pharmacodynamics

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    cover image ACM Conferences
    BCB '16: Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics
    October 2016
    675 pages
    ISBN:9781450342254
    DOI:10.1145/2975167
    Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author.

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    Published: 02 October 2016

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    Author Tags

    1. B-cell epitope prediction
    2. antihapten antibodies
    3. drugs
    4. nonpeptidic antigens
    5. pharmacodynamics
    6. pharmacokinetics

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