DIGNiFI: Discovering causative genes for orphan diseases using protein-protein interaction networks
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- DIGNiFI: Discovering causative genes for orphan diseases using protein-protein interaction networks
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Prioritization of potential candidate disease genes by topological similarity of protein-protein interaction network and phenotype data
Display Omitted We construct a reliable heterogeneous network by fusing multiple networks.We devise a random walk based algorithm on the reliable heterogeneous network.Combining topological similarity with phenotype data helps to predict causal ...
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Candidate gene prioritization for non-communicable diseases based on functional information: Case studies
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Highlights- Integrating functional information could improve the performance of prioritization.
AbstractCandidate gene prioritization for complex non-communicable diseases is essential to understanding the mechanism and developing better means for diagnosing and treating these diseases. Many methods have been developed to prioritize ...
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