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Simulator for Simulating and Monitoring the Hypotensive Patients Blood Pressure Response of Phenylephrine Bolus Injection and Infusion with Open-loop and Closed-loop Treatment

Published: 20 January 2017 Publication History

Abstract

In this paper, we introduce a model-based simulator for hypotensive patients' blood pressure response to vasopressor drug phenylephrine (PHP) delivery. The simulator is designed based on a model of the mean arterial pressure (MAP) response to PHP infusion. The model is data-driven learning model which is illustrated to be adequately describing inter - and intra patients' response to PHP. In the simulator, besides open loop operation, such as manual PHP bolus injection and continuous infusion, a closed-loop control module is also designed, including an anti-windup PI controller, an adaptive controller and an empirical controller, to regulate the blood pressure at target level and maintain hemodynamic stability in hypotensive patients. In addition, three frequent scenarios happened in clinical treatment are modeled in challenge module. They are sodium nitroprusside (SNP) treatment, baseline pressure drop and hemorrhage. The simulator can be operated with two different interfaces; one is the MPA trend response interface and the other is real-time monitoring interface. The real-time monitoring is real-time synchronization presenting blood pressure waves, heart rate and EtCO2 waves under open and closed-loop treatment. The simulator is capable to train the doctors on the dose of PHP usage for the hypotensive patients with different challenges during the treatment.

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Cited By

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  • (2020)Blood pressure response simulator to vasopressor drug infusion (PressorSim)International Journal of Control10.1080/00207179.2020.1742385(1-15)Online publication date: 25-Mar-2020
  • (2020)Robust delay‐dependent LPV synthesis for blood pressure control with real‐time Bayesian parameter estimationIET Control Theory & Applications10.1049/iet-cta.2019.065114:10(1334-1345)Online publication date: Jul-2020

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cover image ACM Other conferences
ICCMS '17: Proceedings of the 8th International Conference on Computer Modeling and Simulation
January 2017
207 pages
ISBN:9781450348164
DOI:10.1145/3036331
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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  • Central Queensland University
  • University of Canberra: University of Canberra

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New York, NY, United States

Publication History

Published: 20 January 2017

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Author Tags

  1. Blood pressure dynamic modeling
  2. Closed-loop infusion
  3. Hypotensive patient
  4. Phenylephrine drug delivery
  5. Real-time monitoring
  6. Simulator

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Cited By

View all
  • (2020)Blood pressure response simulator to vasopressor drug infusion (PressorSim)International Journal of Control10.1080/00207179.2020.1742385(1-15)Online publication date: 25-Mar-2020
  • (2020)Robust delay‐dependent LPV synthesis for blood pressure control with real‐time Bayesian parameter estimationIET Control Theory & Applications10.1049/iet-cta.2019.065114:10(1334-1345)Online publication date: Jul-2020

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