skip to main content
10.1145/3093293.3093303acmotherconferencesArticle/Chapter ViewAbstractPublication PagesicbbtConference Proceedingsconference-collections
research-article

Study of New Connectivity Measure for fMRI Based Cortical Clustering

Published: 14 May 2017 Publication History

Abstract

Resting state Functional magnetic resonance imaging (rsfMRI) provides complementary information to the sulcal brain anatomy about the cytoarchitecture and function of the human brain. Hence due to this parcellation based on rsfMRI is popular for potential application. This paper presents a comparison of correlation based connectivity measures and addresses the question what connectivity measure should be used for fMRI based connectivity analysis. It is observed that the popularly used functional connectivity measure does not show an adequate performance and is also computationally expensive. A new measure of connectivity is suggested and evaluated in the present work based on geodesic distance. A quantitative performance provides evidence that the proposed geodesic distance measure performs best for the connectivity studies.

References

[1]
Bharat, B., F ZerrinYetkin, Victor M Haughton, and James S Hyde, "Functional connectivity in the motor cortex of resting human brain using echo-planar mri," Magnetic resonance in medicine, vol. 34, no. 4, pp. 537-- 541, 1995
[2]
Marcus E Raichle, Ann Mary MacLeod, Abraham Z Snyder, William J Powers, Debra A Gusnard, and Gordon Shulman, "A default mode of brain function," Proceedings of the National Academy of Sciences, vol. 98, no. 2, pp. 676--682, 2001.
[3]
Olaf Sporns, GiulioTononi, and Rolf Kötter, "The human connectome: a structural description of the human brain," PLoSComputBiol, vol. 1, no. 4, pp. e42, 2005.
[4]
Peter J Rousseeuw, "Silhouettes: a graphical aid to the interpretation and validation of cluster analysis," Journal of computational and applied mathematics, vol. 20, pp. 53--65.
[5]
Stephen M Smith, Diego Vidaurre, Christian F Beckmann, Matthew F Glasser, Mark Jenkinson, Karla L Miller, Thomas E Nichols, Emma C Robinson, GholamrezaSalimi-Khorshidi, Mark W Woolrich, et al., "Functional connect- omics from resting-state fmri," Trends in cognitive sciences, vol. 17, no. 12, pp. 666--682, 2013.
[6]
Simon B Eickhoff, Klaas E Stephan, HartmutMohlberg, Christian Grefkes, Gereon R Fink, KatrinAmunts, and Karl Zilles, "A new spm toolbox for combining probabilistic cyto-architectonic maps and functional imaging data," Neuroimage, vol. 25, no. 4, pp. 1325--1335, 2005.
[7]
MikailRubinov and Olaf Sporns, "Complex network measures of brain connectivity: uses and interpretations," Neuroimage, vol. 52, no. 3, pp. 1059 1069, 2010.
[8]
Stephen M Smith, Karla L Miller, GholamrezaSalimiKhorshidi, Matthew Webster, Christian F Beckmann, Thomas E Nichols, Joseph D Ramsey, and Mark W Woolrich, "Network modelling methods for fmri," Neuroimage, vol. 54, no. 2, pp. 875--891,2011.
[9]
Bertrand Thirion, GaëlVaroquaux, Elvis Dohmatob, and Jean-Baptiste Poline, "Which fmri clustering gives good brain parce-llations?," Frontiers in neuro-science, vol. 8, pp. 167, 2014.
[10]
Thomas Blumensath, Timothy EBehrens, and Stephen M Smith, "Resting state fmri single subject cortical parcellation based on region growing," in International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer, 2012, pp. 188--195.
[11]
ChitreshBhushan, Minqi Chong, Soyoung Choi, Anand A Joshi, Justin P Haldar, Hanna Damasio, and Richard M Leahy, "Temporal non-local means filtering reveals real-time whole-brain cortical interactions in resting fmri," PloS one, vol. 11, no. 7, pp. e0158504, 2016.
[12]
Michaël Bernier, MaximeChamberland, JeanChristopheHoude, MaximeDescot-eaux, and Kevin Whittingstall, "Using fmri non-local means denoising to uncover activation in sub-cortical structures at 1.5t for guided harditractography," Frontiers in human neuroscience, vol. 8, pp. 715, 2014.
[13]
Xi-NianZuo and Xiu-Xia Xing, "Effects of nonlocal diffusion on structural mripreprocessing and default network mapping: statistical comparisons with isotropic/ anisotropic diffusion," PLoS One, vol. 6, no.10, pp. e26703, 2011.
[14]
Yang Fan, Lisa D Nickerson, Huanjie Li, Yajun Ma, BingjiangLyu, Xinyuan Miao, Yan Zhuo, JianqiaoGe, QihongZou, and Jia-Hong Gao, "Functional connectivity based parcellation of the thalamus: an unsupervised clustering method and its validity investigation," Brain connectivity, vol. 5, no. 10, pp. 620--630.
[15]
R Cameron Craddock, G Andrew James, Paul E Holtzheimer, Xiaoping P Hu, and Helen S Mayberg, "A whole brain fmri atlas generated via spatially constrained spectral clustering," Human brain map-ping, vol. 33, no. 8, pp. 1914--1928, 2012.
[16]
Liang Wang, YufengZang, Yong He, Meng Liang, Xinqing Zhang, LixiaTian, Tao Wu, Tianzi Jiang, and Kuncheng Li, "Changes in hippocampal connectivity in the early stages of alzheimer's disease: evidence from resting state fmri," Neuroimage, vol. 31, no. 2, pp. 496-- 504, 2006.
[17]
Jianbo Shi and Jitendra Malik, "Normalized cuts and image segmentation," IEEE Transactions on pattern analysis and machine intelligence, vol. 22, no. 8, pp. 888--905, 2000.
[18]
Matthew, G., Stamatios, N. S., J Anthony Wilson, Timothy S Coalson, Bruce Fischl, Jesper L Andersson, JunqianXu, SaadJbabdi, Matthew Webster, Jonathan R Polimeni, et al., "The minimal preprocessing pipelines for the human connectome project" Neuroimage, vol. 80, pp. 105 124, 2013.
[19]
Described at http://brainsuite.org/svreg_atl as_descripton

Recommendations

Comments

Information & Contributors

Information

Published In

cover image ACM Other conferences
ICBBT '17: Proceedings of the 9th International Conference on Bioinformatics and Biomedical Technology
May 2017
123 pages
ISBN:9781450348799
DOI:10.1145/3093293
© 2017 Association for Computing Machinery. ACM acknowledges that this contribution was authored or co-authored by an employee, contractor or affiliate of a national government. As such, the Government retains a nonexclusive, royalty-free right to publish or reproduce this article, or to allow others to do so, for Government purposes only.

In-Cooperation

  • Department of Computer Science, University of Szeged: Department of Computer Science, University of Szeged
  • University of Lisbon: University of Lisbon

Publisher

Association for Computing Machinery

New York, NY, United States

Publication History

Published: 14 May 2017

Permissions

Request permissions for this article.

Check for updates

Author Tags

  1. Brain Atlas
  2. Parcellation
  3. connectivity measures
  4. fMRI
  5. rsfMRI

Qualifiers

  • Research-article
  • Research
  • Refereed limited

Conference

ICBBT '17

Contributors

Other Metrics

Bibliometrics & Citations

Bibliometrics

Article Metrics

  • 0
    Total Citations
  • 51
    Total Downloads
  • Downloads (Last 12 months)3
  • Downloads (Last 6 weeks)0
Reflects downloads up to 05 Mar 2025

Other Metrics

Citations

View Options

Login options

View options

PDF

View or Download as a PDF file.

PDF

eReader

View online with eReader.

eReader

Figures

Tables

Media

Share

Share

Share this Publication link

Share on social media