ABSTRACT
Panax ginseng has a potential to enhance the growth of vascular endothelial cells and to suppress the proliferation of vascular smooth muscle cells. These capabilities have captured our interest to encapsulate ginseng within poly (lactic-co-glycolic acid) (PLGA) microcapsules by a double emulsion technique for cardiovascular application. The microcapsules were characterized by using ATR-FTIR, SEM and imageJ software. The ginseng was successfully encapsulated within the PLGA microcapsules with the appearance of O--H and C=C bands which attributed to the chemical functionality of ginseng. Spherical morphology and smooth wall surface of microcapsules were found on both samples with lower diameter of microcapsules for the ginseng encapsulated PLGA microcapsules compared to the PLGA microcapsules. The encapsulation of ginseng inside PLGA microcapsules will be beneficial for further clinical development in cardiovascular treatment and therapeutic such as drug delivery, coating and casting materials.
- Shin, B. K., Kwon, S. W., and Park, J. H. 2015. Chemical diversity of ginseng saponins from Panax ginseng. J. Ginseng Res. 39(4), 287--298.Google ScholarCross Ref
- Du, J., Cui, C. H., Park, S. C., Kim, J. K., Yu, H. S., et al. 2014. Identification and characterization of a ginsenoside-transforming β-glucosidase from Pseudonocardia sp. Gsoil 1536 and its application for enhanced production of minor ginsenoside Rg2 (S). PloS one 9(6), e96914.Google ScholarCross Ref
- Lu, J. M., Yao, Q., and Chen, C. 2009. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr. Vasc. Pharmacol. 7(3), 293--302.Google ScholarCross Ref
- Yang, X., Xiong, X., Wang, H., and Wang, J. 2014. Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies. Evid. Based Complement Alternat. Med. Vol. 2014.Google Scholar
- Oh, M. J., Kim, H. J., Park, E. Y., Ha, N. H., Song, M. G., et al. 2017. The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice. J. Ginseng Res. 41(1), 52--59.Google ScholarCross Ref
- Lee, C. H., and Kim, J. H. 2014. A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. J. Ginseng Res. 38(3), 161--166.Google ScholarCross Ref
- Lee, S., and Rhee, D. K. 2017. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic--pituitary--adrenal axis. J. Ginseng Res. 41(4), 589--594.Google ScholarCross Ref
- Kim, M., Choi, S. Y., Kim, K. T., Rhee, Y. K., and Hur, J. 2017. Ginsenoside Rg18 suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglia and amyloid-β-induced oxidative stress in SH-SY5Y neurons via nuclear factor erythroid 2-related factor 2/heme oxygenase-1 induction. J. Funct. Foods 31, 71--78.Google ScholarCross Ref
- Zhang, S., Liu, J., Ge, B., Du, M., Fu, L., et al. 2017. Enhanced antitumor activity in A431 cells via encapsulation of 20 (R) ginsenoside Rg3 in PLGA nanoparticles. Drug Dev. Ind. Pharm. 43 (10), 1734--1741.Google ScholarCross Ref
- Tavares, M., Cabral, R. P., Costa, C., Martins, P., Fernandes, A. R., et al. 2017. Development of PLGA dry powder microparticles by supercritical CO 2-assisted spray-drying for potential vaccine delivery to the lungs. J. Supercrit. Fluids 128, 235--243.Google ScholarCross Ref
- Fan, Y. L., Hou, H. W., Tay, H. M., Guo, W. M., Berggren, P. O., et al. 2017. Preservation of Anticancer and Immunosuppressive Properties of Rapamycin Achieved Through Controlled Releasing Particles. AAPS PharmSciTech 18 (7) 2648--2657.Google ScholarCross Ref
- Reardon, P. J., Parhizkar, M., Harker, A. H., Browning, R. J., Vassileva, V., et al. 2017. Electrohydrodynamic fabrication of core--shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment. Int. J. Nanomedicine 12, 3913--3926.Google ScholarCross Ref
- Chen, Y., Gu, Q., Yue, Z., Crook, J. M., Moulton, S. E., et al. 2017. Development of drug-loaded polymer microcapsules for treatment of epilepsy. Biomater. Sci., 5(10), 2159--2168.Google ScholarCross Ref
- Makadia, H. K., and Siegel, S. J. 2011. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers, 3(3), 1377--1397.Google ScholarCross Ref
- Hines, D. J., and Kaplan, D. L. 2013. Poly (lactic-co-glycolic) acid- controlled-release systems: experimental and modeling insights. Crit. Rev. Ther. Drug Carrier Syst. 30(3), 257--276.Google ScholarCross Ref
- Lee, J. A., Jung, B. G., Kim, T. H., Kim, Y. M., Park, M. H., et al. 2014. Poly d, l-lactide-co-glycolide (PLGA) nanoparticle-encapsulated honeybee (Apis melifera) venom promotes clearance of Salmonella enterica serovar Typhimurium infection in experimentally challenged pigs through the up-regulation of T helper type 1 specific immune responses. Vet. Immunol. Immunopathol. 161(3), 193--204.Google Scholar
- Miswan, Z., Lukman, S. K., Majid, F. A. A., Loke, M. F., Saidin, S., et al. 2016. Drug-eluting coating of ginsenoside Rg1 and Re incorporated poly (lactic-co-glycolic acid) on stainless steel 316L: Physicochemical and drug release analyses. Int. J. Pharm. 515(1), 460--466.Google ScholarCross Ref
- Rocha-Selmi, G. A., Bozza, F. T., Thomazini, M., Bolini, H. M., and Fávaro-Trindade, C. S. 2013. Microencapsulation of aspartame by double emulsion followed by complex coacervation to provide protection and prolong sweetness. Food Chem. 139 (1), 72--78.Google ScholarCross Ref
- Jia, J., Wang, C., Chen, K., and Yin, Y. 2017. Drug release of yolk/shell microcapsule controlled by pH-responsive yolk swelling. Chem. Eng. J. 327, 953--961.Google ScholarCross Ref
- Aziz, H. A., Tan, Y. T. F., and Peh, K. K. 2012. Solubility of drugs in aqueous polymeric solution: effect of ovalbumin on microencapsulation process. AAPS PharmSciTech 13(1), 35--45.Google ScholarCross Ref
- Wang, J., Li, S., Fan, Y., Chen, Y., Liu, D., et al. 2010. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng. J. Ethnopharmacol. 130 (2), 421--423.Google ScholarCross Ref
- Freiberg, S., and Zhu, X. X. 2004. Polymer microspheres for controlled drug release. Int. J. Pharm. 282 (1), 1--18.Google ScholarCross Ref
Index Terms
- Ginseng Encapsulated in Poly (lactic-co-glycolic acid) Microcapsules for Cardiovascular Application
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