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Shadow Attacks on MEDA Biochips

Published: 05 November 2018 Publication History

Abstract

The Micro-electrode-dot-array (MEDA) is a next-generation digital microfluidic biochip (DMFB) platform that supports fine-grained control and real-time sensing of droplet movements. These capabilities permit continuous monitoring and checkpoint-based validation of assay execution on MEDA. This paper presents a class of “shadow attacks” that abuse the timing slack in the assay execution. State-of-the-art checkpoint-based validation techniques cannot expose the shadow operations. We develop a defense that introduces extra checkpoints in the assay execution at time instances when the assay is prone to shadow attacks. Experiments confirm the effectiveness and practicality of the defense.

References

[1]
2016. FDA Advisors Back Approval of Baebies' SEEKER Analyzer for Newborns. (2016). http://baebies.com/fda-advisors-back-approval-baebies-seeker-analyzer-newborns
[2]
S.S. Ali, M. Ibrahim, J. Rajendran, O. Sinanoglu, and K. Chakrabarty. 2016. Supply-Chain Security of Digital Microfluidic Biochips. IEEE Computer 49, 8 (2016), 36–43.
[3]
S.S. Ali, M. Ibrahim, O. Sinanoglu, K Chakrabarty, and R. Karri. 2015. Security implications of cyberphysical digital microfluidic biochips. In Proc. IEEE Intl. Conf. Comput. Design. 483–486.
[4]
B. Bhattacharjee and H. Najjaran. 2009. Size dependent droplet actuation in digital microfluidic systems. In Proc. SPIE, Micro- and Nanotechnol. Sensors, Syst., Applications, Vol. 7318.
[5]
S. Bhattacharjee, S. Poddar, S. Roy, J. Huang, and B.B. Bhattacharya. 2017. Dilution and Mixing Algorithms for Flow-Based Microfluidic Biochips. IEEE Trans. on CAD of Integr Circuits Syst. 36, 4 (2017), 694–627.
[6]
S. Bhattacharjee, J. Tang, M. Ibrahim, K. Chakrabarty, and R. Karri. 2018. Locking of Biochemical Assays for Digital Microfluidic Biochips. In Proc. European Test Symp. 1–6.
[7]
B. Bhattacharya, S. Roy, and S. Bhattacharjee. 2014. Algorithmic Challenges in Digital Microfluidic Biochips: Protocols, Design, and Test. In Proc. ICAA. 1–16.
[8]
Alphonsus H.C., K. Choi, R.P. Luoma, J.M. Robinson, and A.R. Wheeler. 2012. Digital Microfluidic Magnetic Separation for Particle-Based Immunoassays. Anal. Chem. 84, 20 (2012), 8805–8812.
[9]
S. Chakraborty, C. Das, and S. Chakraborty. 2018. Securing Module-Less Synthesis on Cyberphysical Digital Microfluidic Biochips from Malicious Intrusions. In Intl Conf. VLSI Design VLSID. 467–468.
[10]
K. Choi, A. Ng, R. Fobel, D. Chang-Yen, E. Yarnell, E. Pearson, M. Oleksak, A. Fischer, R. Luoma, J. Robinson, J. Audet, and A. Wheeler. 2013. Automated Digital Microfluidic Platform for Magnetic-Particle-Based Immunoassays with Optimization by Design of Experiments. Analytical Chemistry 85, 20 (2013), 9638–9646.
[11]
R.B. Fair. 2007. Digital microfluidics: is a true lab-on-a-chip possible? Microfluid Nanofluid 3, 3 (2007), 245–281.
[12]
R.B Fair, A. Khlystov, T Tailor, V. Ivanov, R. Evans, V. Srinivasan, V. Pamula, M. Pollack, P. Griffin, and J. Zhou. 2007. Chemical and Biological Applications of Digital-Microfluidic Devices. IEEE Des. Test. Comput. 24, 1 (2007), 10–24.
[13]
D. Grissom, C. Curtis, S. Windh, S. Phung, N. Kumar, Z. Zimmerman, K OâĂŸNeal, J. McDaniel, N. Liao, and P. Brisk. 2015. An Open-source Compiler and PCB Synthesis Tool for Digital Microfluidic Biochips. Integration: The VLSI Journal 51 (2015), 169–193.
[14]
J.L. He, A.T. Chen, J.H. Lee, and S.K. Fan. 2015. Digital Microfluidics for Manipulation and Analysis of a Single Cell. Intl. J. Molecular Sciences 16, 9 (2015), 22319–22332.
[15]
T. Ho, K Chakrabarty, and P. Pop. 2011. Digital microfluidic biochips: recent research and emerging challenges. In Proc. IEEE/ACM Intl. Conf Hardware/Software Codesign Syst Synthesis. 335–344.
[16]
M Ibrahim, K. Chakrabarty, and K. Scott. 2017. Synthesis of Cyberphysical Digital-Microfluidic Biochips for Real-Time Quantitative Analysis. IEEE Trans. on CAD of Integr. Circuits and Syst. 36, 5 (2017), 733–746.
[17]
O. Keszocze, Z. Li, A. Grimmer, R. Wille, K Chakrabarty, and R. Drechsler. 2017. Exact Routing for Micro-Electrode-Dot-Array Digital Microfluidic Biochips. In Proc. ASP Design Automation Conf 708–713.
[18]
Z. Li, T.Y. Ho, KY.T. Lai, K. Chakrabarty, P.H. Yu, and C.Y. Lee. 2016. High-level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips. In Proc. of Design Automation Conf 1–6.
[19]
Z. Li, K. Lai, P.H. Yu, K. Chakrabarty, T.Y. Ho, and C.Y. Lee. 2017. Droplet Size-Aware High-Level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips. IEEE Trans. Biomed. Circuits Syst. 11, 3 (2017), 612–626.
[20]
Z Li, K.Y. Lai, Po-Hsien Yu, K. Chakrabarty, M. Pajic, T. Ho, and C. Lee. 2016. Error recovery in a micro-electrode-dot-array digital microfluidic biochip. In Proc. Intl. Conf Comput. Aided Design. 1–8.
[21]
Z. Li, K.Y.T. Lai, K. Chakrabarty, T.Y. Ho, and C.Y. Lee. 2017. Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips. IEEE Trans. Biomed. Circuits Syst. 11, 6 (2017), 1380–1391.
[22]
P. Roy and A. Banerjee. 2016. A new approach for root-causing attacks on digital microfluidic devices. In Proc. IEEE Asian Hardware-Oriented Sec. Trust Conf 1–6.
[23]
J. Tang, M. Ibrahim, K. Chakrabarty, and R. Karri. 2018. Secure Randomized Checkpointing for Digital Microfluidic Biochips. IEEE Trans. on CAD 37, 6 (2018), 1119–1132.
[24]
J Tang, R Karri, M Ibrahim, and K Chakrabarty. 2016. Securing digital microfluidic biochips by randomizing checkpoints. In Proc. IEEE Intl. Test Conf 1–8.
[25]
N. Vergauwe, D. Witters, F. Ceyssens, S. Vermeir, B. Verbruggen, R. Puers, and J. Lammertyn. 2011. A versatile electrowetting-based digital microfluidic platform for quantitative homogeneous and heterogeneous bio-assays. J. Micromechanics Microengineering 21, 5 (2011), 054026.
[26]
G. Wang, D. Teng, and S.K. Fan. 2011. Digital Microfluidic Operations on Micro-Electrode Array Architecture. In Proc. Intl. Conf on Nano/Micro Engineered Molecular Syst. 1180–1183.
[27]
G. Wang, D. Teng, Y.T. Lai, Y.W. Lu, Y. Ho, and C.Y. Lee. 2014. Field-programmable lab-on-a-chip based on microelectrode dot array architecture. IET Nanobiotech-nology 8, 3 (2014), 163–171.
[28]
Y. Zhao, T. Xu, and K. Chakrabarty. 2010. Integrated Control-Path Design and Error Recovery in the Synthesis of Digital Microfluidic Lab-on-Chip. ACM J. on Emerg. Technol. in Comput. Syst. 6, 3 (2010), 11:1–11:28.
[29]
Z. Zhong, Z. Li, and K. Chakrabarty. 2017. Adaptive Error Recovery in MEDA Biochips Based on Droplet-Aliquot Operations and Predictive Analysis. In Proc. of Intl. Conf Comput. Aided Design. 615–622.

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  • (2023)A Survey on Security and Privacy Challenges in State-of-the-Art Microfluidic BiochipsIETE Technical Review10.1080/02564602.2023.224534341:3(297-311)Online publication date: 24-Aug-2023
  • (2022)A Survey on Security of Digital Microfluidic Biochips: Technology, Attack, and DefenseACM Transactions on Design Automation of Electronic Systems10.1145/349469727:4(1-33)Online publication date: 12-Feb-2022
  • (2021)MEDASecProceedings of the 2021 Great Lakes Symposium on VLSI10.1145/3453688.3461520(277-282)Online publication date: 22-Jun-2021
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      cover image Guide Proceedings
      2018 IEEE/ACM International Conference on Computer-Aided Design (ICCAD)
      Nov 2018
      939 pages

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      IEEE Press

      Publication History

      Published: 05 November 2018

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      • (2023)A Survey on Security and Privacy Challenges in State-of-the-Art Microfluidic BiochipsIETE Technical Review10.1080/02564602.2023.224534341:3(297-311)Online publication date: 24-Aug-2023
      • (2022)A Survey on Security of Digital Microfluidic Biochips: Technology, Attack, and DefenseACM Transactions on Design Automation of Electronic Systems10.1145/349469727:4(1-33)Online publication date: 12-Feb-2022
      • (2021)MEDASecProceedings of the 2021 Great Lakes Symposium on VLSI10.1145/3453688.3461520(277-282)Online publication date: 22-Jun-2021
      • (2021)Tools for SecuritySecurity of Biochip Cyberphysical Systems10.1007/978-3-030-93274-9_4(33-60)Online publication date: 21-Dec-2021
      • (2021)Architecture for SecuritySecurity of Biochip Cyberphysical Systems10.1007/978-3-030-93274-9_3(19-32)Online publication date: 21-Dec-2021
      • (2021)IntroductionSecurity of Biochip Cyberphysical Systems10.1007/978-3-030-93274-9_1(1-10)Online publication date: 21-Dec-2021
      • (2020)Towards Secure Checkpointing for Micro-Electrode-Dot-Array BiochipsIEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems10.1109/TCAD.2020.2979972(1-1)Online publication date: 2020
      • (2019)Bio-chemical Assay Locking to Thwart Bio-IP TheftACM Transactions on Design Automation of Electronic Systems10.1145/336557925:1(1-20)Online publication date: 22-Nov-2019
      • (2019)Security Assessment of Microfluidic ImmunoassaysProceedings of the International Conference on Omni-Layer Intelligent Systems10.1145/3312614.3312658(217-222)Online publication date: 5-May-2019
      • (2019)Toward Secure Microfluidic Fully Programmable Valve Array BiochipsIEEE Transactions on Very Large Scale Integration (VLSI) Systems10.1109/TVLSI.2019.292491527:12(2755-2766)Online publication date: Dec-2019

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