ABSTRACT
In this paper, we mainly focus on automatic detection and segmentation of cell nuclei in histopathology images. Though some methods have been presented to solve these issues, there is scope for efficiency and performance to improve. We propose an end-to-end trainable convolutional neural network, which can learn the object-level and pixel-level information of image patches. In this way, the output feature map could be applied in nuclei detection and segmentation tasks concurrently. Then the weighted patch aggregation and refinement methods are utilized to achieve the final segmentation result. The experiments on the standard public dataset demonstrate that that our method achieves a good performance on nuclei detection and segmentation.
- Gurcan, Metin N., et al. "Histopathological image analysis: A review." Journal, IEEE reviews in biomedical engineering 2 (2009): 147--171.Google ScholarCross Ref
- Xu, Jun, et al. "Stacked sparse autoencoder (SSAE) for nuclei detection on breast cancer histopathology images." Journal, IEEE transactions on medical imaging, pp. 119--130, 2016.Google ScholarCross Ref
- Fatakdawala, Hussain, et al. "Expectation-maximization-driven geodesic active contour with overlap resolution (emagacor): Application to lymphocyte segmentation on breast cancer histopathology." IEEE Transactions on Biomedical Engineering, pp.1676--1689, 2010.Google ScholarCross Ref
- Al-Kofahi, Yousef, et al. "Improved automatic detection and segmentation of cell nuclei in histopathology images." IEEE Transactions on Biomedical Engineering, pp. 841--852, 2010.Google ScholarCross Ref
- Wienert, Stephan, et al. "Detection and segmentation of cell nuclei in virtual microscopy images: a minimum-model approach." Scientific reports, pp.503, 2012.Google ScholarCross Ref
- Veta, Mitko, et al. "Automatic nuclei segmentation in H&E stained breast cancer histopathology images." PloS one 8.7 (2013): e70221.Google ScholarCross Ref
- Janowczyk, Andrew, and Anant Madabhushi. "Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use cases." Journal of pathology informatics, 2016.Google ScholarCross Ref
- Qi, Xin, et al. "Robust segmentation of overlapping cells in histopathology specimens using parallel seed detection and repulsive level set." IEEE Transactions on Biomedical Engineering, pp. 754--765, 2012.Google Scholar
- Arel, Itamar, Derek C. Rose, and Thomas P. Karnowski. "Deep machine learning a new frontier in artificial intelligence research {research frontier}." IEEE Computational Intelligence Magazine, pp. 13--18, 2010. Google ScholarDigital Library
- Krizhevsky, Alex, Ilya Sutskever, and Geoffrey E. Hinton. "Imagenet classification with deep convolutional neural networks." Advances in neural information processing systems, 2012. Google ScholarDigital Library
- Hariharan, Bharath, et al. "Simultaneous detection and segmentation." European Conference on Computer Vision. Springer International Publishing, 2014.Google Scholar
- Liu, Shu, et al. "Multi-scale patch aggregation (mpa) for simultaneous detection and segmentation." Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016.Google Scholar
- Jia, Yangqing, et al. "Caffe: Convolutional architecture for fast feature embedding." Proceedings of the 22nd ACM international conference on Multimedia, ACM, 2014. Google ScholarDigital Library
Index Terms
- Simultaneous Detection and Segmentation of Cell Nuclei based on Convolutional Neural Network
Recommendations
Vertebrae Segmentation from X-ray Images Using Convolutional Neural Network
IHIP 2018: Proceedings of the 2018 International Conference on Information Hiding and Image ProcessingNOTICE OF RETRACTION: While investigating potential publication-related misconduct in connection with the IHIP 2018 Conference Proceedings, serious concerns were raised that cast doubt on the integrity of the peer-review process and all papers published ...
Segmentation of clustered nuclei based on curvature weighting
IVCNZ '12: Proceedings of the 27th Conference on Image and Vision Computing New ZealandCluster of nuclei are frequently observed in thick tissue section images. It is very important to segment overlapping nuclei in many biomedical applications. Many existing methods tend to produce under segmented results when there is a high overlap ...
3D anisotropie convolutional neural network with step transfer learning for liver segmentation
ICCIP '18: Proceedings of the 4th International Conference on Communication and Information ProcessingAutomatic liver segmentation on computed tomography (CT) slices plays an important role in current clinical practice for liver cancer supporting diagnosis. While manual segmentation is accurate and precise, it is time-consuming and tedious. Otherwise, ...
Comments