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Application of classification for figure copying test in Parkinson's disease diagnosis by using cartesian genetic programming

Published: 13 July 2019 Publication History

Abstract

Previous studies have proposed an objective non-invasive approach to assist diagnosing neurological diseases such as Alzheimer and Parkinson's diseases by asking patients to perform certain drawing tasks against certain figure. However, the approach of rating those drawing test results is still very subjective by relying on manual measurements. By extracting features of the drawn figure from the raw data, which is generated from the digitized tablet that patients can draw on, we can use supervised learning to train the evolutionary algorithm with those extracted data, and therefore evolves an automated classifier to analyse and classify those drawing accurately. Cartesian Genetic Programming (CGP) is an improved version of conventional Genetic Programming (GP). As GP adapts the tree structure, redundancy issue exists as the tree develops more nodes with the evolution of the GP by mutation and crossover. CGP addresses this issue by using fixed number of nodes and arities, evolves by using mutation only. The outcome of this research is a highly efficient, accurate, automated classifier that can not only classify clinical drawing test results, which can provide up to 80% accuracy, but also assisting clinicians and medical experts to investigate how those features are used by the algorithm and how each component can impact patient's cognitive function.

References

[1]
M. Emre, Aarsland Dag, R. Brown, D. J. Burn, C. Duyckaerts, Y. Mizuno, G. A. Broe, J. Cummings, D. W. Dickson, S. Gauthier, J. Goldman, C. Goetz, K. Amos, A. Lees, R. Levy, I. Litvan, I. McKeith, W. Olanow, W. Poewe, N. Quinn, C. Sampaio, E. Tolosa and B. Dubois, "Clinical Diagnostic Criteria for Dementia Associated with Parkinson's Disease," Movement Disorder, vol. 22, no. 12, pp. 1689--1707, 2007.
[2]
J. Jankovic, "Parkinson's disease: clinical features and diagnosis," Journal of Neurology, Neurosurgery, and Psychiatry, no. 79, pp. 368--376, 2008.
[3]
T. M. Mitchell, Machine Learning, The McGraw-Hill Companies Inc., 1997.
[4]
C. Gao, S. Smith, M. Lones, S. Jamieson, J. Alty, J. Cosgrove, P. Zhang, J. Liu, Y. Chen, J. Du, S. Cui, H. Zhou and S. Chen, "Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: clinical validation," Translational Neurodegeneration, vol. 7, no. 18, 2018.
[5]
H. Brodaty and C. M. Moore, "The Clock Drawing Test For Dementia of the Alzheimer's Type: A Comparison of Three Scoring Methods in a Memory Disorders Clinic," International Journal of Geriatric Psychiatry, vol. 12, pp. 619--627, 1997.
[6]
S. Salimi, M. Irish, D. Foxe, J. R. Hodge, O. Piguet and R. J. Burrell, "Can Visuospatial Measures Improve the Diagnosis of Alzheimer's Disease?," Alzheimer's & Dementia: Diagonsis, Assessment & Disease Monitoring, vol. 10, pp. 66--74, 2018.
[7]
M. J. Sleegers, J. J. Beutler, W. J. Hardon, J. Berden, J. C. Verhave, J. Conemans, D. A. Hollander, P. L. Dautzenberg and E. K. Hoogeveen, "Reversible Rapidly Progressive Dementia with Parkinsonism Induced by Valproate in a Patient with Systemic Lupus Erythematosus," Journal of the American Geriatrics Society, vol. 58, no. 4, pp. 799--801, 2010.
[8]
R. Canham, S. L. Smith and A. M. Tyrrell, "Automated Scoring of a Neuropsychological Test: The Rey Osterrieth Complex Figure," in EUROMICRO, 2000.
[9]
B. Agrell and O. Dehun, "The clock-drawing test," Age and Ageing, pp. 399--403, 1998.
[10]
M. F. Folstein, S. E. Folstein and P. R. McHugh, ""MINI-MENTAL STATE": A practical method for grading the cognitive state of patients for the clinician," Journal of Psychiatric Research, pp. 189--198, 11 1975.
[11]
V. C. Pangman, J. Sloan and L. Guse, "An examination of psychometric properties of the Mini-Mental State Examination and the Standardized Mini-Mental State Examination: Implications for clinical practice," Applied Nursing Research, pp. 209--213, 11 2000.
[12]
J. G. Bremner, R. Morse, S. Hughes and G. Andreasen, "Relations between Drawing Cubes and Copying Line Diagrams of Cubes in 7-to-10-Year-Old Children," Child Development, vol. 71, no. 3, pp. 621--634, 2000.
[13]
N. A. C. Center, "FTLD Module Instructions for Neuropsychological Questionnaires (Forms C2F - C6F) and Test Reported on Form C1F," 2012.
[14]
S. Z. Nasreddine, A. N. Phillips, V. Bedirian, S. Charbonneau, V. Whitehead, I. Collin, L. J. Cummings and H. Chertkow, "The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment," J Am Geriatr Soc, vol. 53, pp. 695--699, 2005.
[15]
J. F. Miller, Cartesian Genetic Programming, Springer, 2011.

Cited By

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  • (2025)Medical Data Classification Using Genetic Programming: A Systematic Literature ReviewExpert Systems10.1111/exsy.7000742:3Online publication date: 5-Feb-2025
  • (2024)Dynamically Sampling biomedical Images For Genetic ProgrammingProceedings of the Genetic and Evolutionary Computation Conference Companion10.1145/3638530.3654202(515-518)Online publication date: 14-Jul-2024
  • (2024)Adaptive Sampling of Biomedical Images with Cartesian Genetic ProgrammingParallel Problem Solving from Nature – PPSN XVIII10.1007/978-3-031-70055-2_16(256-272)Online publication date: 14-Sep-2024

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  1. Application of classification for figure copying test in Parkinson's disease diagnosis by using cartesian genetic programming

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      cover image ACM Conferences
      GECCO '19: Proceedings of the Genetic and Evolutionary Computation Conference Companion
      July 2019
      2161 pages
      ISBN:9781450367486
      DOI:10.1145/3319619
      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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      Publication History

      Published: 13 July 2019

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      Author Tags

      1. cartesian genetic programming
      2. clinical drawing test
      3. genetic programming
      4. machine learning

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      GECCO '19: Genetic and Evolutionary Computation Conference
      July 13 - 17, 2019
      Prague, Czech Republic

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      View all
      • (2025)Medical Data Classification Using Genetic Programming: A Systematic Literature ReviewExpert Systems10.1111/exsy.7000742:3Online publication date: 5-Feb-2025
      • (2024)Dynamically Sampling biomedical Images For Genetic ProgrammingProceedings of the Genetic and Evolutionary Computation Conference Companion10.1145/3638530.3654202(515-518)Online publication date: 14-Jul-2024
      • (2024)Adaptive Sampling of Biomedical Images with Cartesian Genetic ProgrammingParallel Problem Solving from Nature – PPSN XVIII10.1007/978-3-031-70055-2_16(256-272)Online publication date: 14-Sep-2024

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