skip to main content
10.1145/3326172.3326205acmotherconferencesArticle/Chapter ViewAbstractPublication PagesicbetConference Proceedingsconference-collections
research-article

Spectroscopic Properties of Blood for Pulse Oximeter Design

Authors Info & Claims
Published:28 March 2019Publication History

ABSTRACT

Pulse oximeter is an important medical device as it is used for emergency situations in hospitals for monitoring patient's peripheral oxygen saturation (%SpO2). For more than 30 years many research studies have focused on designing a wearable compact pulse oximeter device for accurate %SpO2 measurements. Most of these devices provide values that are either 2% above or below the desired %SpO2 values, calculated using arterial blood gas (ABG). Pulse oximeter provides %SpO2 readings of arterial blood and the pulse rate through convenient placement of the sensor on the finger. In the transmittance type pulse oximeter, the absorbance of light by oxy hemoglobin and de-oxy hemoglobin is measured at two wavelengths one each from the Red band and the Infrared (IR) band. The two band's combined wavelength ranges from 600nm to 1000nm on the electromagnetic spectrum. At each wavelength, the light is detected after placing a finger between the light source and the detector of spectrophotometer. The detected signal consists of a cardiac synchronous AC signal which is due to the changes in arterial blood volume, and the DC level which is due to bone, tissue and non-pulsatile blood. The ratio of signals corresponding to Red and IR bands is calculated and is related to arterial oxygen saturation. In this paper, we investigate the spectral properties of blood through spectrophotometer-based readings from finger in the wavelength range of 600nm to 1000nm and determine the optimum wavelength combination for designing the transmittance type pulse oximeter. For this purpose, a comparison of all combinations of Red and IR band wavelengths was carried out. The results of our study indicate that more than one combination of wavelengths can be used for designing pulse oximeters based on the absorbance values observed in the IR and Red bands

References

  1. Y. Mendelson, "Pulse Oximetry: Theory and Applications for Noninvasive Monitoring," Clinical Chemistry, vol. 38, no. 9, pp. 1601--1607, 1992.Google ScholarGoogle ScholarCross RefCross Ref
  2. J. Hinkelbein, D. Hose, and F. Fiedler, "Comparison of three different sensor sites for pulse oximetry in critically ill patients," International Journal of Intensive Care, pp. 1--5, 2005.Google ScholarGoogle Scholar
  3. J. Das, A. Aggarwal, and N. K. Aggarwal, "Pulse oximeter accuracy and precision at five different sensor locations in infants and children with cyanotic heart disease.," Indian journal of anaesthesia, vol. 54, no. 6, pp. 531--4, Nov. 2010.Google ScholarGoogle ScholarCross RefCross Ref
  4. S. DeMeulenaere, "Pulse Oximetry: Uses and Limitations," Journal for Nurse Practitioners, vol. 3, no. 5, pp. 312--317, 2007.Google ScholarGoogle ScholarCross RefCross Ref
  5. D. Press, M. Nitzan, A. Romem, and R. Koppel, "Pulse oximetry: fundamentals and technology update.," Medical devices (Auckland, N.Z.), vol. 7, pp. 231--9, 2014.Google ScholarGoogle Scholar
  6. S. Lopez, "Pulse Oximeter Fundamentals and Design," 2012.Google ScholarGoogle Scholar
  7. R. A. Ismail and S. F. Babiker, "Oxygen Level Measurement Techniques: Pulse Oximetry," 2014.Google ScholarGoogle Scholar
  8. S. Bagha and L. Shaw, "A Real Time Analysis of PPG Signal for Measurement of SpO 2 and Pulse Rate," no. May, 2014.Google ScholarGoogle Scholar
  9. P. Oximeter, M. Output, E. Of, D. Averaging, and O. Accuracy, "Addendum to Monitor Instructions," pp. 1--4, 2001.Google ScholarGoogle Scholar
  10. M. Nitzan et al., "Calibration-free pulse oximetry based on two wavelengths in the infrared - A preliminary study," Sensors (Switzerland), vol. 14, no. 4, pp. 7420--7434, 2014.Google ScholarGoogle ScholarCross RefCross Ref
  11. P. D. Mannheimer, J. R. Casciani, M. E. Fein, and S. L. Nierlich, "Wavelength Selection for Low-Saturation Pulse Oximetry," vol. 44, no. 3, pp. 148--158, 1997.Google ScholarGoogle Scholar
  12. D. F. Swinehart, "The beer-lambert law," J. Chem. Educ, vol. 39, no. 7, p. 333, 1962.Google ScholarGoogle ScholarCross RefCross Ref
  13. E. D. Chan, M. M. Chan, and M. M. Chan, "Pulse oximetry: Understanding its basic principles facilitates appreciation of its limitations," Respiratory Medicine, vol. 107, no. 6, pp. 789--799, 2013.Google ScholarGoogle ScholarCross RefCross Ref
  14. S. Ibrahim, "The Electromagnetic Spectrum by Dr. Syed Ibrahim," no. June, 2017.Google ScholarGoogle Scholar
  15. J. Spigulis, A. Lihachev, L. Gailite, and R. Erts, "Novel laser technologies for human skin in-vivo assessment," no. June, 2008.Google ScholarGoogle Scholar
  16. M. Drahanský, O. Kanich, E. Březinová, and K. Shinoda, "Experiments with Optical Properties of Skin on Fingers," vol. 6, no. 2, pp. 37--46, 2016.Google ScholarGoogle Scholar
  17. R.Rox Anderson; John A. Parrish, "Optics of human skin.pdf." the journal of investigative dermatology, 77:13--19,1981, 1981.Google ScholarGoogle Scholar
  18. V. V. Barun, A. P. Ivanov, A. V. Volotovskaya, and V. S. Ulashchik, "Absorption spectra and light penetration depth of normal and pathologically altered human skin," Journal of Applied Spectroscopy, vol. 74, no. 3, pp. 430--439, 2007.Google ScholarGoogle ScholarCross RefCross Ref
  19. A. R. Young, "Chromophores in human skin," Physics in Medicine and Biology, vol. 42, no. 5, pp. 789--802, 1997.Google ScholarGoogle ScholarCross RefCross Ref
  20. G. Zonios, J. Bykowski, and N. Kollias, "Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy," Journal of Investigative Dermatology, vol. 117, no. 6, pp. 1452--1457, 2001.Google ScholarGoogle ScholarCross RefCross Ref
  21. M. Shimada, Y. Yamada, M. Itoh, and T. Yatagai, "Melanin and blood concentration in a human skin model studied by multiple regression analysis: assessment by Monte Carlo simulation," vol. 46, pp. 2397--2406, 2001.Google ScholarGoogle Scholar
  22. D. Yudovsky and L. Pilon, "Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance," vol. 49, no. 10, pp. 1707--1719, 2010.Google ScholarGoogle Scholar
  23. T. Igarashi, K. Nishino, and S. K. Nayar, "The Appearance of Human Skin: A Survey," Foundations and Trends® in Computer Graphics and Vision, vol. 3, no. 1, pp. 1--95, 2007. Google ScholarGoogle ScholarDigital LibraryDigital Library
  24. A. N. Bashkatov, E. A. Genina, V. I. Kochubey, and V. V. Tuchin, "Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm," Journal of Physics D: Applied Physics, vol. 38, no. 15, pp. 2543--2555, 2005.Google ScholarGoogle ScholarCross RefCross Ref
  25. A. K. Saha, "Hydrothermal synthesis of near-infra-red emitting quantum dots for fluorescent and magnetic bimodal imaging," no. August 2011, 2017.Google ScholarGoogle Scholar
  26. C. Ash, M. Dubec, K. Donne, and T. Bashford, "Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods," 2017.Google ScholarGoogle ScholarCross RefCross Ref
  27. a Airinei and A. Sadoveanu, "Spectrophotometric Analysis of the Blood Plasma," Romanian Journal of Biophysics, vol. 16, no. 3, pp. 215--20, 2006.Google ScholarGoogle Scholar
  28. V. A. P. Erekatova, P. A. S. Ubochev, and M. I. K. Leshnin, "Optimal wavelengths for optoacoustic measurements of blood oxygen saturation in biological tissues," vol. 7, no. 10, pp. 422--437, 2016.Google ScholarGoogle Scholar
  29. H. Gehring, C. Hornberger, and H. M. Me, "The Effects of Motion Artifact and Low Perfusion on the Performance of a New Generation of Pulse Oximeters in Volunteers Undergoing Hypoxemia," vol. 47, no. 1, pp. 48--60, 2002.Google ScholarGoogle Scholar
  30. J. L. Plummer, A. Z. Zakaria, A. H. Ilsley, R. R. L. Fronsko, and H. Owen, "Evaluation of the influence of movement on saturation readings from pulse oximeters," vol. 50, no. August 1994, pp. 423--426, 1995.Google ScholarGoogle Scholar
  31. S. Barker, W. Hay, K. Miyasasaka, and C. Poets, "Principles of Pulse Oximetry Technology," Pulse Oximetry, 2002.Google ScholarGoogle Scholar
  32. R. Stojanovic and D. Karadaglic, "Design of an oximeter based on LED-LED configuration and FPGA technology," Sensors (Switzerland), vol. 13, no. 1, pp. 574--586, 2013.Google ScholarGoogle ScholarCross RefCross Ref
  33. S. Andruschenko, J. Kraitl, U. Timm, E. Lewis, and H. Ewald, "Novel Algorithm for 'AC/DC' Ratio Calculation of Pulse Signals using Energy criteria of the Pulse," Biomed Tech, vol. 55, no. 1, pp. 2--5, 2010.Google ScholarGoogle Scholar
  34. P. M. Mohan, A. A. Nisha, V. Nagarajan, and E. S. J. Jothi, "Measurement of Arterial Oxygen Saturation (SpO 2) using PPG Optical Sensor," pp. 1136--1140, 2016.Google ScholarGoogle Scholar
  35. Z. Walton, "EliScholar -- A Digital Platform for Scholarly Publishing at Yale Measuring Venous Oxygen Saturation Using the Photoplethysmograph Waveform," 2010.Google ScholarGoogle Scholar
  36. W. Karlen, J. Lim, J. M. Ansermino, G. Dumont, and C. Scheffer, "Design challenges for camera oximetry on a mobile phone Design Challenges for Camera Oximetry on a Mobile Phone," no. August, 2012.Google ScholarGoogle Scholar
  37. P. Kyriacou, K. Budidha, T. Y. Abay, and U. Kingdom, "Optical Techniques for Blood and Tissue Oxygenation Optical Techniques for Blood and Tissue Oxygenation," no. January, pp. 0--12, 2018.Google ScholarGoogle Scholar

Index Terms

  1. Spectroscopic Properties of Blood for Pulse Oximeter Design

    Recommendations

    Comments

    Login options

    Check if you have access through your login credentials or your institution to get full access on this article.

    Sign in
    • Published in

      cover image ACM Other conferences
      ICBET '19: Proceedings of the 2019 9th International Conference on Biomedical Engineering and Technology
      March 2019
      327 pages
      ISBN:9781450361309
      DOI:10.1145/3326172

      Copyright © 2019 ACM

      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

      Publisher

      Association for Computing Machinery

      New York, NY, United States

      Publication History

      • Published: 28 March 2019

      Permissions

      Request permissions about this article.

      Request Permissions

      Check for updates

      Qualifiers

      • research-article
      • Research
      • Refereed limited

    PDF Format

    View or Download as a PDF file.

    PDF

    eReader

    View online with eReader.

    eReader