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Major Depressive Disorder Shows Frequency-specific Abnormal Functional Connectivity Patterns Associated with Anhedonia

Published: 17 May 2019 Publication History

Abstract

Anhedonia is a core feature of major depression disorder (MDD), is associated with the dysfunction of the dopamine system. Here, we aimed to examine how resting-state functional connectivity (FC) within the dopamine system in MDD patients is related to anhedonia and whether this relationship relies on specific frequency bands (slow 4: 0.027-0.073 Hz and slow 5: 0.01-0.027 Hz). The regional connectivity strength and FC were evaluated. Our results revealed decreased connectivity strength in MDD in the posterior cingulate cortex and hippocampus at slow 4 and in the anterior insula and hippocampus at slow 5. Of note, increased FC in the mesocorticolimbic system was found in MDD only at slow 5. Furthermore, the altered connectivity at slow 5 contributed to predicting anhedonia symptom and depression severity. These findings suggest that dopamine system functional connectivity remains a prime target for understanding the anhedonia of MDD.

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    ICMHI '19: Proceedings of the 3rd International Conference on Medical and Health Informatics
    May 2019
    207 pages
    ISBN:9781450371995
    DOI:10.1145/3340037
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    Published: 17 May 2019

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    Author Tags

    1. Major depressive disorder
    2. anhedonia
    3. dopamine system
    4. functional connectivity

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