skip to main content
10.1145/3340074.3340093acmotherconferencesArticle/Chapter ViewAbstractPublication PagesicbbtConference Proceedingsconference-collections
research-article

Magnetically Targeted Drug Delivery System through Imaging Technology PID Feedback Control and MATLAB

Authors Info & Claims
Published:29 May 2019Publication History

ABSTRACT

Conventional dose such as capsules which are used traditionally have severe side effects including raising of blood sugar level by dissolution of drug in blood, can be overcome by replacing traditional drug delivery with specifically targeted drug delivery system. The main concept of using magnetic levitation for drug delivery is to deliver the drug to a specific point via magnetic actuation and imaging technique, magnetic material encoated by drug can rupture the artery by getting strongly attracted towards externally applied magnetic field. By taking magnetically levitated drug to the targeted area, it will minimize the risk of rupturing of the artery. Dispersion of drug will be minimized as drug-coated core will be under influence of applied electromagnetic field, drug can be released by altering electromagnetic fields. In this study, one-dimensional (1D) force system is used. Two forces counter each other i.e. electromagnetic force and gravitational force. Addition of Ki to Kp and Kd speeds up the motion when reaching to the targeted set point, blob stays in levitated condition around the set point thus stability is increased by the addition of Ki but oscillation are still present that hinders the stability of the system. Exponential function is introduced to decrease the power of Kp, in result, it supplies the power when the error is large, power gets zero when error is reduced to zero. In this stable system, Kp and Kd gain are applied to minimize the oscillations and keep the blob levitated at targeted set point.

References

  1. Trafton, A. Tumors targeted using tiny gold particles. MIT Tech Talk. 53, 4--4, 2009.Google ScholarGoogle Scholar
  2. Kiessling F., Mertens M. E., Grimm J., and Lammers T. Nanoparticles for imaging: top or flop? Radiology. 273: 10--28. 2014.Google ScholarGoogle ScholarCross RefCross Ref
  3. Senyei A., Widder K., et al., Magnetic guidance of drug-carrying microspheres. Journal of Applied Physics 49 (6), 3578--3583. 1978.Google ScholarGoogle ScholarCross RefCross Ref
  4. Widder K. J., Senyei A. E., et al., Magnetic microspheres---model system for site specific drug delivery in vivo. Proceedings of the Society for Experimental Biology and Medicine 158 (2), 141--146. 1978.Google ScholarGoogle ScholarCross RefCross Ref
  5. Mosbach, K., Schroder, U., Preparation and application of magnetic polymers for targeting of drugs. FEBS Letters 102 (1), 112--116. 1979.Google ScholarGoogle ScholarCross RefCross Ref
  6. Corchero J. L. and Villaverde A. Biomedical applications of distally controlled magnetic nanoparticles. Trends Biotechnol. 2009 Aug; 27(8):468--76. 2009.Google ScholarGoogle Scholar
  7. Perez J. M., Simeone F. J., Saeki Y., Josephson L., Weissleder R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. Aug 27; 125(34):10192--3. 2003.Google ScholarGoogle Scholar
  8. A. S. Lübbe et al., Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res., 56: 4694--4701, 1996.Google ScholarGoogle Scholar
  9. Woodley J. Bioadhesion: new possibilities for drug administration? Clin pharmacokinet. 40, 77--84, 2001.Google ScholarGoogle Scholar
  10. Widder, K. J., Senyei A. E., and Scarpelli D. G. Magnetic microspheres: A model system for site specific drug delivery in vivo. Exp. Biol. Med. 158, 141--146, 1978.Google ScholarGoogle ScholarCross RefCross Ref
  11. Lisa Brannon-Peppas, James O. Blanchette, Nanoparticle and targeted systems for cancer therapy, Advanced Drug Delivery Reviews, Volume 56, Issue 11, Pages 1649--1659, ISSN 0169-409X.Google ScholarGoogle Scholar

Index Terms

  1. Magnetically Targeted Drug Delivery System through Imaging Technology PID Feedback Control and MATLAB

    Recommendations

    Comments

    Login options

    Check if you have access through your login credentials or your institution to get full access on this article.

    Sign in
    • Published in

      cover image ACM Other conferences
      ICBBT '19: Proceedings of the 2019 11th International Conference on Bioinformatics and Biomedical Technology
      May 2019
      156 pages
      ISBN:9781450362313
      DOI:10.1145/3340074

      Copyright © 2019 ACM

      © 2019 Association for Computing Machinery. ACM acknowledges that this contribution was authored or co-authored by an employee, contractor or affiliate of a national government. As such, the Government retains a nonexclusive, royalty-free right to publish or reproduce this article, or to allow others to do so, for Government purposes only.

      Publisher

      Association for Computing Machinery

      New York, NY, United States

      Publication History

      • Published: 29 May 2019

      Permissions

      Request permissions about this article.

      Request Permissions

      Check for updates

      Qualifiers

      • research-article
      • Research
      • Refereed limited
    • Article Metrics

      • Downloads (Last 12 months)6
      • Downloads (Last 6 weeks)0

      Other Metrics

    PDF Format

    View or Download as a PDF file.

    PDF

    eReader

    View online with eReader.

    eReader