ABSTRACT
Conventional dose such as capsules which are used traditionally have severe side effects including raising of blood sugar level by dissolution of drug in blood, can be overcome by replacing traditional drug delivery with specifically targeted drug delivery system. The main concept of using magnetic levitation for drug delivery is to deliver the drug to a specific point via magnetic actuation and imaging technique, magnetic material encoated by drug can rupture the artery by getting strongly attracted towards externally applied magnetic field. By taking magnetically levitated drug to the targeted area, it will minimize the risk of rupturing of the artery. Dispersion of drug will be minimized as drug-coated core will be under influence of applied electromagnetic field, drug can be released by altering electromagnetic fields. In this study, one-dimensional (1D) force system is used. Two forces counter each other i.e. electromagnetic force and gravitational force. Addition of Ki to Kp and Kd speeds up the motion when reaching to the targeted set point, blob stays in levitated condition around the set point thus stability is increased by the addition of Ki but oscillation are still present that hinders the stability of the system. Exponential function is introduced to decrease the power of Kp, in result, it supplies the power when the error is large, power gets zero when error is reduced to zero. In this stable system, Kp and Kd gain are applied to minimize the oscillations and keep the blob levitated at targeted set point.
- Trafton, A. Tumors targeted using tiny gold particles. MIT Tech Talk. 53, 4--4, 2009.Google Scholar
- Kiessling F., Mertens M. E., Grimm J., and Lammers T. Nanoparticles for imaging: top or flop? Radiology. 273: 10--28. 2014.Google ScholarCross Ref
- Senyei A., Widder K., et al., Magnetic guidance of drug-carrying microspheres. Journal of Applied Physics 49 (6), 3578--3583. 1978.Google ScholarCross Ref
- Widder K. J., Senyei A. E., et al., Magnetic microspheres---model system for site specific drug delivery in vivo. Proceedings of the Society for Experimental Biology and Medicine 158 (2), 141--146. 1978.Google ScholarCross Ref
- Mosbach, K., Schroder, U., Preparation and application of magnetic polymers for targeting of drugs. FEBS Letters 102 (1), 112--116. 1979.Google ScholarCross Ref
- Corchero J. L. and Villaverde A. Biomedical applications of distally controlled magnetic nanoparticles. Trends Biotechnol. 2009 Aug; 27(8):468--76. 2009.Google Scholar
- Perez J. M., Simeone F. J., Saeki Y., Josephson L., Weissleder R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. Aug 27; 125(34):10192--3. 2003.Google Scholar
- A. S. Lübbe et al., Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res., 56: 4694--4701, 1996.Google Scholar
- Woodley J. Bioadhesion: new possibilities for drug administration? Clin pharmacokinet. 40, 77--84, 2001.Google Scholar
- Widder, K. J., Senyei A. E., and Scarpelli D. G. Magnetic microspheres: A model system for site specific drug delivery in vivo. Exp. Biol. Med. 158, 141--146, 1978.Google ScholarCross Ref
- Lisa Brannon-Peppas, James O. Blanchette, Nanoparticle and targeted systems for cancer therapy, Advanced Drug Delivery Reviews, Volume 56, Issue 11, Pages 1649--1659, ISSN 0169-409X.Google Scholar
Index Terms
- Magnetically Targeted Drug Delivery System through Imaging Technology PID Feedback Control and MATLAB
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