Birga Anteneh Mengesha
ABSTRACT
The use of systems biology and bioinformatics to deal with the complexity inherent in aging research has played a major role. Genome-wide association studies (GWAS) is a means of detecting longevity-associated with genetic variants. The numbers of genetic variants found to associate with longevity and the most convincing human longevity genes today are APOE and FOXO3A which have frequently been associated with longevity. We conducted a systematic review to identify studies that contain the relevant data. Odds ratios (OR) and 95% confidence interval (CI) and P<0.05 for significant tests were used to figure out the genomic association between the genes and human longevity. There are a positive association of rs2802288 (OR = 1.08, 95% CI = 0.93-1.25, p = 0.03) and rs2764264 (OR = 1.25, 95% CI = 0.90-1.73, P = 0.01) between FOXO3A polymorphisms and human longevity on pooled analysis, specifically with male longevity but there is no association with rs13220810 polymorphism (OR = 0.96, 95% CI = 0.80-1.16, P = 0.31). Rs7412 polymorphism of APOE indicates a significant association which was more likely with human longevity (OR = 1.30, 95% CI = 0.50-2.83, P = 0.01) and rs429358 polymorphism of APOE was less likely to occurred for longevity with a negative significant association (OR = 0.50, 95% CI = 0.37-0.67, P = 0.01). It was confirmed that there are an association between FOXO3A and APOE with human longevity on polymorphisms. Further genotyping should be done to verify more potential markers or polymorphisms related to human longevity.
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Index Terms
- Genome-wide Association of APOE and FOXO3A for human longevity: A Systematic Review
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