ABSTRACT
The present work aims to provide an implemented program using LabVIEW ™ software for the recognition of tubular atrophy in renal biopsy images.
The procedure for the assessment of the kidney transplantability involves the visual analysis of one or more samples of renal tissue taken by percutaneous renal biopsy techniques. The sample is subsequently treated with histomorphological or histochemical staining techniques and subsequently analyzed by optical microscopy. The images obtained were elaborated to highlight the atrophic and physiological tubules and inflammatory cells often involved in cases of tubulointerstitial nephritis (TIN).
The aim is to facilitate the task of the pathologist by providing information on the functional score to reduce observation and diagnosis times and consequently speed up renal transplant operations.
- Anglicheau D, Loupy A, Lefaucheur C, Pessione F, Letourneau I, Cote I, Gaha K, et al. A simple clinico-histopathological composite scoring system is highly predictive of graft outcomes in marginal donors. Am J Transplant 2008;8:2325--2334Google Scholar
- Remuzzi G1 CP, Perna A, Dimitrov BD, Turturro M, Locatelli G, Rigotti P, Baldan N, Beatini M, Valente U, Scalamogna M, Ruggenenti P; Dual Kidney Transplant Group. Long-term outcome of renal transplantation from older donors. N Engl J Med. 2006;26;354(4):343--52..Google Scholar
- Monini, S., Filippi, C., Marinozzi, F., di Traglia, M., Bini, F., Marchelletta, S., Ferraioli, M., Margani, V., Marinelli, A., and Barbara, M. 2019. Validation of the objective assessment of facial movement with a new software-based system. Acta Oto-Laryngologica 139, 5, 456--460.Google ScholarCross Ref
- Monini, S., Marinozzi, F., Atturo, F., Bini, F., Marchelletta, S., and Barbara, M. 2017. Proposal of Video-recording System for the Assessment of Bell's palsy: Methodology and Preliminary Results. Otol. Neurotol. 38, 8, 1178--1185.Google ScholarCross Ref
- Marinozzi, F., Novelli, S., Morabito, V., Bini, F., Berloco, P. B., Carpino, G., Rossi, M., et al. 2012. Preliminary study of early histomorphometric changes in hepatic steatosis. Transplant Proc. 44, 1837--1842.Google ScholarCross Ref
- Duan F, Qin Y, Fu X, Ma L, Huang T, Zhang C. Simple spectral reduction algorithm used for the echelle spectrometer. Appl Opt 2018;57:8921--8927.Google Scholar
- Marinozzi, F., Bini, F., Marinozzi, A., Zuppante F., De Paolis, A., Pecci R., and Bedini, R. 2013. Technique for bone volume measurement from human femur head samples by classification of micro-CT image histograms. Ann. I. Super. Sanità 49, 3, 300--305.Google Scholar
- Trimboli, P., Bini, F., Andrioli, M., Giovanella, L., Thorel, M.F., Ceriani, L., Valabrega, S., Lenzi, A., Drudi, F. M., Marinozzi, F., and Romanelli, F. 2015. Analysis of tissue surrounding thyroid nodules by ultrasound digital images. Endocrine 48, 2, 434--438.Google ScholarCross Ref
- Eikmans M, Gielis EM, Ledeganck KJ, Yang J, Abramowicz D, Claas FFJ. Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies. Front Med (Lausanne) 2018;5:358.Google Scholar
- Adani GL, Baccarani U, Crestale S, Pravisani R, Isola M, Tulissi P, Vallone C, et al. Kidney Transplantation in Elderly Recipients: A Single-Center Experience. Transplant Proc 2018.Google Scholar
- Ayorinde JO, Summers DM, Pankhurst L, Laing E, Deary AJ, Hemming K, Wilson EC, et al. PreImplantation Trial of Histopathology In renal Allografts (PITHIA): a stepped-wedge cluster randomised controlled trial protocol. BMJ Open 2019;9:e026166.Google Scholar
Index Terms
- Hystomorphometric Analysis of Kidney Targets for Transplant. Pilot Study
Recommendations
Interactive image analysis programs for quantifying injury-induced axonal beading and microtubule disruption
Focal axonal beading and focal disruption of microtubule structure are characteristic to traumatic axonal injury. We have recently reproduced these morphological and structural changes in our in vitro model system [D. Kilinc, G. Gallo, K.A. Barbee, ...
Involving Patients in the Cadaveric Kidney Transplant Allocation Process: A Decision-Theoretic Perspective
The United Network for Organ Sharing system of allocating cadaveric kidneys for transplantation permits only minimal involvement of patients in the selection process. The system ignores potential variations in the importance that patients may attach to ...
Machine Learning for Dynamically Predicting the Onset of Renal Replacement Therapy in Chronic Kidney Disease Patients Using Claims Data
Applications of Medical Artificial IntelligenceAbstractChronic kidney disease (CKD) represents a slowly progressive disorder that can eventually require renal replacement therapy (RRT) including dialysis or renal transplantation. Early identification of patients who will require RRT (as much as 1 year ...
Comments