Jianzhi Deng
ABSTRACT
In this paper, we try to find the differentially expressed lncRNA and differentially expressed miRNA of Liver cancer, especially between the different gender's patients. The differentially expressed genes were screened from TCGA liver data. Based on the extracted differentially expressed lncRNAs and differentially expressed miRNAs, we reveal an 8-lncRNA (TTTY14, UCA1, LINC00162, TTTY10, XIST, ERVH48-1, ZFY-AS1 and TTTY15) to 3-miRNA (hsa-mir-506, hsa-mir-508, hsa-mir-205) regulatory network of 13 pairs inter-regulatory between male and female. The 8 differentially expressed lncRNAs in the lncRNA-miRNA regulatory network were analyzed by the multivariable COX regression model, and LINC00162 and TTTY10 were found as the co-expression differentially expressed lncRNAs. After survival kmplot analysis and receiver operating characteristic analysis of the co-expression differentially expressed lncRNAs, TTTY10 was selected and proved as the potential biomarker of liver cancer for the diagnose and therapy.
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Index Terms
- Gene Big Data Analysis of Differentially Expressed lncRNA and MiRNA in Liver Cancer with Different Gender
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