Changyi Sun
ABSTRACT
Heart and brain (AD) diseases are easier to happen to people who are aged. Traditional therapies are not able to cure the disease and the stem cell is chosen to be applied as new therapy. However, there are many moral problems related to stem cells, so another typical therapy is developed, which is IPS therapy. IPS therapy is mainly about inducing stem cells from the somatic cells of patients then deriving them into typical cells we need to treat diseases, which avoid many moral problems. In this article, IPS therapy on treating heart disease on different species and its application on AD are summarized. Though there are disadvantages of IPS therapy, IPS therapy is promising based on the current progress.
- Grochowski, C., E. Radzikowska, and R. Maciejewski, Neural stem cell therapy-Brief review. Clin Neurol Neurosurg, 2018. 173: p. 8-14.Google Scholar
- Zakrzewski, W., , Stem cells: past, present, and future. Stem Cell Res Ther, 2019. 10(1): p. 68.Google Scholar
- Goradel, N.H., , Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases. J Cell Biochem, 2018. 119(1): p. 95-104.Google Scholar
- Hayashi, Y., K. Ohnuma, and M.K. Furue, Pluripotent Stem Cell Heterogeneity. Adv Exp Med Biol, 2019. 1123: p. 71-94.Google Scholar
- Mashinchian, O., , The Muscle Stem Cell Niche in Health and Disease. Curr Top Dev Biol, 2018. 126: p. 23-65.Google Scholar
- Scadden, D.T., The stem-cell niche as an entity of action. Nature, 2006. 441(7097): p. 1075-9.Google Scholar
- Okano, H. and S. Yamanaka, iPS cell technologies: significance and applications to CNS regeneration and disease. Mol Brain, 2014. 7: p. 22.Google ScholarCross Ref
- Hamazaki, T., , Concise Review: Induced Pluripotent Stem Cell Research in the Era of Precision Medicine. Stem Cells, 2017. 35(3): p. 545-550.Google Scholar
- de Lázaro, I., A. Yilmazer, and K. Kostarelos, Induced pluripotent stem (iPS) cells: a new source for cell-based therapeutics? J Control Release, 2014. 185: p. 37-44.Google Scholar
- Hockemeyer, D. and R. Jaenisch, Induced Pluripotent Stem Cells Meet Genome Editing. Cell Stem Cell, 2016. 18(5): p. 573-86.Google Scholar
- Laflamme, M.A. and C.E. Murry, Heart regeneration. Nature, 2011. 473(7347): p. 326-35.Google Scholar
- Price, E.L., J.M. Vieira, and P.R. Riley, Model organisms at the heart of regeneration. Dis Model Mech, 2019. 12(10).Google ScholarCross Ref
- Müller, P., H. Lemcke, and R. David, Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and Improvement Strategies. Cell Physiol Biochem, 2018. 48(6): p. 2607-2655.Google Scholar
- Tellechea, P., , Early- and late-onset Alzheimer disease: Are they the same entity? Neurologia, 2018. 33(4): p. 244-253.Google Scholar
- Lane, C.A., J. Hardy, and J.M. Schott, Alzheimer's disease. Eur J Neurol, 2018. 25(1): p. 59-70.Google Scholar
- Mungenast, A.E., S. Siegert, and L.H. Tsai, Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. Mol Cell Neurosci, 2016. 73: p. 13-31.Google Scholar
- Shiba, Y., , Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature, 2016. 538(7625): p. 388-391.Google Scholar
- Laflamme, M.A., , Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol, 2007. 25(9): p. 1015-24.Google Scholar
- Ishigami, M., , Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts. Plos One, 2018. 13(8).Google ScholarCross Ref
- Shiba, Y., , Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature, 2012. 489(7415): p. 322-5.Google Scholar
- Ye, L., , Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell, 2014. 15(6): p. 750-61.Google Scholar
- Kikuchi, T., , Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model. Nature, 2017. 548(7669): p. 592-596.Google Scholar
- Lundin, A., , Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models. Stem Cell Reports, 2018. 10(3): p. 1030-1045.Google ScholarCross Ref
- Yahata, N., , Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One, 2011. 6(9): p. e25788.Google ScholarCross Ref
- Li, X., , Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell, 2015. 17(2): p. 195-203.Google Scholar
- Essayan-Perez, S., , Modeling Alzheimer's disease with human iPS cells: advancements, lessons, and applications. Neurobiol Dis, 2019. 130: p. 104503.Google Scholar
- Wen, Z., , Synaptic dysregulation in a human iPS cell model of mental disorders. Nature, 2014. 515(7527): p. 414-8.Google Scholar
- Xu, X., , Prevention of beta-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events. Stem Cell Res, 2013. 10(2): p. 213-27.Google Scholar
- Fujiwara, N., , Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells. Exp Neurol, 2015. 271: p. 423-31.Google Scholar
- Barker, R.A., , Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era. Cell Stem Cell, 2017. 21(5): p. 569-573.Google Scholar
Index Terms
- The Progress of IPS Therapy on the Heart and Neural Disease
Recommendations
An automatic system to identify heart disease risk factors in clinical texts over time
Display Omitted We proposed a hybrid system to automatically identify heart disease risk factors.We divided different types of risk factors into three categories according to their descriptions.Our system achieves an F-score of 92.86% on 2014 i2b2 ...
Using local lexicalized rules to identify heart disease risk factors in clinical notes
Display Omitted We created a set of task-specific dictionaries related to heart disease.We designed generic rules for risk factors identification.The results are aggregated at the document level.Temporal attributes are assigned class-specific ...
Risk Factors Analysis and Classification on Heart Disease
AbstractIn recent years, there has been a high prevalence rate of heart disease (HD) among 50-year-old people in China. It has become the first disease of old ages death. It is a very interesting and challenging work to have an effective early forecasting ...
Comments