ABSTRACT
As of late 2020, much is still unknown about the novel SARS-CoV-2 virus, including what health risks could be present for current patients. We know that while being infected with the disease, patients are struck with many respiratory issues. However, little is known about the long-term effects COVID-19 survivors could be affected by. Using differential expression analysis, we identified several differentially expressed genes in COVID-19 positive patients that indicate an increase in the risk for heart disease in these patients - APOL3, KLF15, and CD163. These genes indicate an increase of risk for cardiovascular disease through increased apolipoprotein levels, decreased negative regulators for risk factors, and increased inflammation and infection.
- Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395: 507--513.Google Scholar
- Wolfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Muller M.A., Niemeyer D., Jones T.C., Vollmar P., Rothe C. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 doi: 10.1038/s41586-020-2196-x.Google ScholarCross Ref
- Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8: 420--422.Google Scholar
- Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clin Chim Acta. 2020; 505: 190--191. doi: 10.1016/j.cca.2020.03.004Google ScholarCross Ref
- Forster P, Forster L, Renfrew C, Forster M. Phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci USA2020;117(17): 9241--9243.Google Scholar
- Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020;12(7): 6049--6057. doi:10.18632/aging.103000Google ScholarCross Ref
- Costa-Silva J, Domingues D, Lopes FM (2017) RNA-Seq differential expression analysis: An extended review and a software tool. PLoS ONE 12(12): e0190152. https://doi.org/10.1371/journal.pone.0190152Google ScholarCross Ref
- Nicole A. P. Lieberman, et al. "In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age." bioRxiv 2020.06.22.165225; doi: https://doi.org/10.1101/2020.06.22.165225Google ScholarCross Ref
- Love, M.I. et al. (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15. doi:10.1186/s13059-014-0550-8Google ScholarCross Ref
- Robinson M.D. et al. (2009) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics, 26, 139--140.Google ScholarDigital Library
- Benjamini Y. and Hochberg Y. (1995) Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society: Series B (Methodological), 57, 289--300.Google ScholarCross Ref
- Khalil, Alia, et al. "Apolipoprotein L3 Interferes with Endothelial Tube Formation via Regulation of ERK1/2, FAK and Akt Signaling Pathway." Atherosclerosis, vol. 279, 2018, pp. 73--87. PubMed, doi: 10.1016/j.atherosclerosis.2018.10.023.Google ScholarCross Ref
- Patel, Sheila K., et al. "Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy." International Journal of Molecular Sciences, vol. 19, no. 5, Apr. 2018. PubMed Central, doi:10.3390/ijms19051303.Google ScholarCross Ref
- Wang, Junning, et al. "Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome." PLOS ONE, vol. 9, no. 11, Nov. 2014, p. e112127. PLoS Journals, doi: 10.1371/journal.pone.0112127.Google ScholarCross Ref
Index Terms
- RNA-seq Reveals the Increased Risk of Heart and Cardiovascular Disease by SARS-CoV-2 Infection
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