skip to main content
10.1145/3448748.3448753acmotherconferencesArticle/Chapter ViewAbstractPublication PagesbicConference Proceedingsconference-collections
research-article

RNA-seq Reveals the Increased Risk of Heart and Cardiovascular Disease by SARS-CoV-2 Infection

Published:21 March 2021Publication History

ABSTRACT

As of late 2020, much is still unknown about the novel SARS-CoV-2 virus, including what health risks could be present for current patients. We know that while being infected with the disease, patients are struck with many respiratory issues. However, little is known about the long-term effects COVID-19 survivors could be affected by. Using differential expression analysis, we identified several differentially expressed genes in COVID-19 positive patients that indicate an increase in the risk for heart disease in these patients - APOL3, KLF15, and CD163. These genes indicate an increase of risk for cardiovascular disease through increased apolipoprotein levels, decreased negative regulators for risk factors, and increased inflammation and infection.

References

  1. Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395: 507--513.Google ScholarGoogle Scholar
  2. Wolfel R., Corman V.M., Guggemos W., Seilmaier M., Zange S., Muller M.A., Niemeyer D., Jones T.C., Vollmar P., Rothe C. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 doi: 10.1038/s41586-020-2196-x.Google ScholarGoogle ScholarCross RefCross Ref
  3. Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., Liu S., Zhao P., Liu H., Zhu L. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020; 8: 420--422.Google ScholarGoogle Scholar
  4. Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clin Chim Acta. 2020; 505: 190--191. doi: 10.1016/j.cca.2020.03.004Google ScholarGoogle ScholarCross RefCross Ref
  5. Forster P, Forster L, Renfrew C, Forster M. Phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci USA2020;117(17): 9241--9243.Google ScholarGoogle Scholar
  6. Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020;12(7): 6049--6057. doi:10.18632/aging.103000Google ScholarGoogle ScholarCross RefCross Ref
  7. Costa-Silva J, Domingues D, Lopes FM (2017) RNA-Seq differential expression analysis: An extended review and a software tool. PLoS ONE 12(12): e0190152. https://doi.org/10.1371/journal.pone.0190152Google ScholarGoogle ScholarCross RefCross Ref
  8. Nicole A. P. Lieberman, et al. "In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age." bioRxiv 2020.06.22.165225; doi: https://doi.org/10.1101/2020.06.22.165225Google ScholarGoogle ScholarCross RefCross Ref
  9. Love, M.I. et al. (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15. doi:10.1186/s13059-014-0550-8Google ScholarGoogle ScholarCross RefCross Ref
  10. Robinson M.D. et al. (2009) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics, 26, 139--140.Google ScholarGoogle ScholarDigital LibraryDigital Library
  11. Benjamini Y. and Hochberg Y. (1995) Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society: Series B (Methodological), 57, 289--300.Google ScholarGoogle ScholarCross RefCross Ref
  12. Khalil, Alia, et al. "Apolipoprotein L3 Interferes with Endothelial Tube Formation via Regulation of ERK1/2, FAK and Akt Signaling Pathway." Atherosclerosis, vol. 279, 2018, pp. 73--87. PubMed, doi: 10.1016/j.atherosclerosis.2018.10.023.Google ScholarGoogle ScholarCross RefCross Ref
  13. Patel, Sheila K., et al. "Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy." International Journal of Molecular Sciences, vol. 19, no. 5, Apr. 2018. PubMed Central, doi:10.3390/ijms19051303.Google ScholarGoogle ScholarCross RefCross Ref
  14. Wang, Junning, et al. "Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome." PLOS ONE, vol. 9, no. 11, Nov. 2014, p. e112127. PLoS Journals, doi: 10.1371/journal.pone.0112127.Google ScholarGoogle ScholarCross RefCross Ref

Index Terms

  1. RNA-seq Reveals the Increased Risk of Heart and Cardiovascular Disease by SARS-CoV-2 Infection

        Recommendations

        Comments

        Login options

        Check if you have access through your login credentials or your institution to get full access on this article.

        Sign in
        • Published in

          cover image ACM Other conferences
          BIC 2021: Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing
          January 2021
          445 pages
          ISBN:9781450390002
          DOI:10.1145/3448748

          Copyright © 2021 ACM

          Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

          Publisher

          Association for Computing Machinery

          New York, NY, United States

          Publication History

          • Published: 21 March 2021

          Permissions

          Request permissions about this article.

          Request Permissions

          Check for updates

          Qualifiers

          • research-article
          • Research
          • Refereed limited
        • Article Metrics

          • Downloads (Last 12 months)6
          • Downloads (Last 6 weeks)0

          Other Metrics

        PDF Format

        View or Download as a PDF file.

        PDF

        eReader

        View online with eReader.

        eReader