Visual analysis based on the research of SARS and COVID-19: a 20-year bibliometric study

Background: At present, with the continuous development of the epidemic, scholars at home and abroad have paid great attention to Corona Virus Discrease 2019(COVID-19), especially with SARS, comprehensive biology combined and carried out a series of research and discussion. Research on such topics has gradually increased, but the hot topics of research still not clear.

Purpose: The goal of the research was to perform a systematic review on the use of biomedicine in medical research with the aim of understanding the global progress on COVID-19 research outcomes, content, methods, and study groups involved.

Methods: The SARS documents were retrieved in the core collection of Web of Science, and analyze the data with Excel and VOSviewer.to perform bibliometric analysis of publication trends, author orders, countries, institutions, collaboration relationships, research hot spots, diseases studied, and research methods.

Data Synthesis: A total of 50,744 original research articles were included. The number of articles published in the first 3 years showed an overall upward trend and then gradually declined to basically the same. It accounts for 2.087% of the total number of posts, reaching a peak of 31050 in 2020, accounting for 61.190% of the total. From 6,976 journals, 18 journals with more than 250 articles published, more than half of the journals are in JCR Zone 1, and most of the influence factors are between 2-7 points; the included literature involves 61684 authors, and most of the authors are scattered. The included literature involved 9738 institutions. Among the first 18 institutions, more than 80% were colleges and hospitals. A total of 37,817 keywords are listed, with an average of 2.65 keywords. The top 7 in frequency of use are acute lung injury, acute respiratory distress syndrome, respiratory-distress-syndrome, aras, mechanical ventilation, and mortality. The centrality is more than 7000, and the number of occurrences is more than 1000. The research direction of SARS focuses on: RESPIRATORY SYSTEM, INFECTIOUS DISEASES, PUBLIC ENVIRONMENTAL OCCUPATIONAL HEALTH, BIOCHEMISTRY MOLECULAR BIOLOGY and HEALTH CARE SCIENCES SERVICES, which are all higher than 27% of the total, and the records are higher than 13,900. High-frequency keyword clustering and overlay view analysis: (1) In terms of mechanism research, gene structure, virus detection, outbreak prevention and protection, etc. are the major research hotspots. (2) In terms of target therapy, animal molecular experiments such as protein, activation, modle mode, potent inhibitors, laboratory tests, and immune response are the research hotspots.

Conclusions: Based on the research of SARS literature, preliminary research suggests that COVID-19 research will increase rapidly by multiples, and the popularity of research continues. In terms of public health and epidemic prevention, the world still needs to form a stronger team. It needs to do a good job of inheritance, achieve full prevention and control performance, innovate results, and explore potential areas with reference to common word clustering and knowledge graphs to promote the emergence of authoritative innovation. Research trends will expand from the development of diagnostics and treatments to the human-society-biological environment, making important contributions to the global fight against the epidemic.