skip to main content
10.1145/3459637.3482220acmconferencesArticle/Chapter ViewAbstractPublication PagescikmConference Proceedingsconference-collections
short-paper

Will Sorafenib Help?: Treatment-aware Reranking in Precision Medicine Search

Published:30 October 2021Publication History

ABSTRACT

High-quality evidence from the biomedical literature is crucial for decision making of oncologists who treat cancer patients. Search for evidence on a specific treatment for a patient is the challenge set by the precision medicine track of TREC in 2020. To address this challenge, we propose a two-step method to incorporate treatment into the query formulation and ranking. Training of such ranking function uses a zero-shot setup to incorporate the novel focus on treatments which did not exist in any of the previous TREC tracks. Our treatment-aware neural reranking approach, FAT, achieves state-of-the-art effectiveness for TREC Precision Medicine 2020. Our analysis indicates that the BERT-based rerankers automatically learn to score documents through identifying concepts relevant to precision medicine, similar to hand-crafted heuristics successful in the earlier studies.

Skip Supplemental Material Section

Supplemental Material

sorafenib (1).mp4

mp4

18.9 MB

References

  1. 2021. BioBERT @ Huggingface model repository. https://huggingface.co/ monologg/biobert_v1.0_pubmed_pmc. Accessed: 2021-02-22.Google ScholarGoogle Scholar
  2. 2021. DrugBank. https://go.drugbank.com/. Accessed: 2021-02-22.Google ScholarGoogle Scholar
  3. 2021. Transformers. https://huggingface.co/transformers/. Accessed: 2021-02-22Google ScholarGoogle Scholar
  4. Maristella Agosti, Giorgio Maria Di Nunzio, and Stefano Marchesin. 2019. An Analysis of Query Reformulation Techniques for Precision Medicine. In SIGIR. Paris, France, 973--976. Google ScholarGoogle ScholarDigital LibraryDigital Library
  5. Gianni Amati and Cornelis Joost Van Rijsbergen. 2002. Probabilistic models of information retrieval based on measuring the divergence from randomness. TOIS, Vol. 20, 4 (2002), 357--389. Google ScholarGoogle ScholarDigital LibraryDigital Library
  6. Hilda Bastian, Paul Glasziou, and Iain Chalmers. [n.d.]. Seventy-five trials and eleven systematic reviews a day: how will we ever keep up? ( n.,d.]).Google ScholarGoogle Scholar
  7. Iz Beltagy, Kyle Lo, and Arman Cohan. 2019. SciBERT: Pretrained Language Model for Scientific Text. In EMNLP.Google ScholarGoogle Scholar
  8. Mette Eriksen and Tove Frandsen. 2018. The impact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: a systematic review. Journal of the Medical Library Association, Vol. 106, 4 (2018), 420--431.Google ScholarGoogle ScholarCross RefCross Ref
  9. Erik Faessler, Michel Oleynik, and Udo Hahn. 2020. What Makes a Top-Performing Precision Medicine Search Engine? Tracing Main System Features in a Systematic Way. In Proceedings of the 43rd International ACM SIGIR Conference on Research and Development in Information Retrieval. 459--468. Google ScholarGoogle ScholarDigital LibraryDigital Library
  10. Jiafeng Guo, Yixing Fan, Liang Pang, Liu Yang, Qingyao Ai, Hamed Zamani, Chen Wu, W. Bruce Croft, and Xueqi Cheng. 2020. A Deep Look into neural ranking models for information retrieval. Information Processing & Management, Vol. 57, 6 (2020), 102067.Google ScholarGoogle ScholarCross RefCross Ref
  11. Gordon Guyatt, John Cairns, David Churchill, Deborah Cook, Brian Haynes, Jack Hirsh, Jan Irvine, Mark Levine, Mitchell Levine, Jim Nishikawa, David Sackett, Patrick Brill-Edwards, Hertzel Gerstein, Jim Gibson, Roman Jaeschke, Anthony Kerigan, Alan Neville, Akbar Panju, Allan Detsky, Murray Enkin, Pamela Frid, Martha Gerrity, Andreas Laupacis, Valerie Lawrence, Joel Menard, Virginia Moyer, Cynthia Mulrow, Paul Links, Andrew Oxman, Jack Sinclair, and Peter Tugwell. 1992. Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine. JAMA, Vol. 268, 17 (1992), 2420--2425.Google ScholarGoogle ScholarCross RefCross Ref
  12. William Hersh, Ravi Teja Bhupatiraju, and Sarah Corley. 2004. Enhancing access to the Bibliome: the TREC Genomics Track. Studies in Health Technology and Informatics, Vol. 107, Pt 2 (2004), 773--777.Google ScholarGoogle Scholar
  13. William Hersh and Ellen Voorhees. 2009. TREC genomics special issue overview. Information Retrieval, Vol. 12 (2009), 1--15. Google ScholarGoogle ScholarDigital LibraryDigital Library
  14. Jon J Hiles and Jill M Kolesar. 2008. Role of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma. American Journal of Health-System Pharmacy, Vol. 65, 2 (2008), 123--131.Google ScholarGoogle ScholarCross RefCross Ref
  15. Xiaoli Huang, Jimmy Lin, and Dina Demner-Fushman. 2006. Evaluation of PICO as a knowledge representation for clinical questions. In AMIA Annual Symposium proceedings. 359--363.Google ScholarGoogle Scholar
  16. Su Nam Kim, David Martinez, Lawrence Cavedon, and Lars Yenken. 2011. Automatic classification of sentences to support Evidence Based Medicine. BMC Bioinformatics, Vol. 12, S5 (2011).Google ScholarGoogle ScholarCross RefCross Ref
  17. Christoph H Lampert, Hannes Nickisch, and Stefan Harmeling. 2009. Learning to detect unseen object classes by between-class attribute transfer. In 2009 IEEE Conference on Computer Vision and Pattern Recognition. IEEE, 951--958.Google ScholarGoogle ScholarCross RefCross Ref
  18. Jinhyuk Lee, Wonjin Yoon, Sungdong Kim, Donghyeon Kim, Sunkyu Kim, Chan Ho So, and Jaewoo Kang. 2019. BioBERT: A pre-trained biomedical language representation model for biomedical text mining. Bioinformatics, Vol. 36, 4 (09 2019), 1234--1240.Google ScholarGoogle Scholar
  19. Jimmy Lin, Rodrigo Nogueira, and Andrew Yates. 2020. Pretrained transformers for text ranking: BERT and beyond. arXiv preprint arXiv:2010.06467 (2020).Google ScholarGoogle Scholar
  20. Xiaofeng Liu, Lu Li, Zuoxi Yang, and Shoubin Dong. 2019. SCUT-CCNL at TREC 2019 Precision Medicine Track. In TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  21. Sean MacAvaney, Arman Cohan, and Nazli Goharian. 2020. SLEDGE: A Simple Yet Effective Baseline for COVID-19 Scientific Knowledge Search. arxiv: 2005.02365 [cs.IR]Google ScholarGoogle Scholar
  22. David Martinez, Sarvnaz Karimi, Lawrence Cavedon, and Timothy Baldwin. 2008. Facilitating biomedical systematic reviews using ranked text retrieval and classification. In Australasian Document Computing Symposium. 53--60.Google ScholarGoogle Scholar
  23. Ryan McDonald, George Brokos, and Ion Androutsopoulos. 2018. Deep Relevance Ranking Using Enhanced Document-Query Interactions. In EMNLP. Brussels, Belgium, 1849--1860.Google ScholarGoogle ScholarCross RefCross Ref
  24. Lowell K Milliken, Sirisha K Motomarry, and Anagha Kulkarni. 2019. ARtPM: article retrieval for precision medicine. Journal of biomedical informatics, Vol. 95 (2019), 103224.Google ScholarGoogle ScholarDigital LibraryDigital Library
  25. Vincent Nguyen, Maciek Rybinski, Sarvnaz Karimi, and Zhenchang Xing. 2020. Pandemic Literature Search: Finding Information on COVID-19. In Proceedings of the The 18th Annual Workshop of the Australasian Language Technology Association. 92--97.Google ScholarGoogle Scholar
  26. NLM. 2021. Medline - NLM. https://www.nlm.nih.gov/medline/. [Online; accessed 26-Feb-2021].Google ScholarGoogle Scholar
  27. Rodrigo Nogueira and Kyunghyun Cho. 2019. Passage Re-ranking with BERT. arXiv:1901.04085 (2019). arxiv: 1901.04085 [cs.IR]Google ScholarGoogle Scholar
  28. Rodrigo Nogueira, Wei Yang, Kyunghyun Cho, and Jimmy Lin. 2019. Multi-stage document ranking with BERT. arXiv preprint arXiv:1910.14424 (2019).Google ScholarGoogle Scholar
  29. U.S National Library of Medicine. 2017. https://meshb.nlm.nih.gov/#/fieldSearch.Google ScholarGoogle Scholar
  30. Cedric Panje, Markus Glatzer, Charlotta Siren, Ludwig Plasswilm, and Paul Putora. 2018. Treatment Options in Oncology. JCO Clinical Cancer Informatics (2018).Google ScholarGoogle Scholar
  31. Marco Tulio Ribeiro, Sameer Singh, and Carlos Guestrin. 2016. "Why Should I Trust You?" Explaining the predictions of any classifier. In Proceedings of the 22nd ACM SIGKDD international conference on knowledge discovery and data mining. 1135--1144. Google ScholarGoogle ScholarDigital LibraryDigital Library
  32. W. Scott Richardson, Mark Wilson, Jim Nishikawa, and Robert Hayward. 1995. The well-built clinical question: a key to evidence-based decisions. ACP Journal Club, Vol. 123, 3 (1995), A12--3.Google ScholarGoogle ScholarCross RefCross Ref
  33. Kirk Roberts, Tasmeer Alam, Steven Bedrick, Dina Demner-Fushman, Kyle Lo, Ian Soboroff, Ellen Voorhees, Lucy Lu Wang, and William Hersh. 2020. TREC-COVID: Rationale and Structure of an Information Retrieval Shared Task for COVID-19. The Journal of the American Medical Informatics Association, Vol. 27, 9 (2020), 1431--1436.Google ScholarGoogle ScholarCross RefCross Ref
  34. Kirk Roberts, Dina Demner-Fushman, Ellen Voorhees, William R. Hersh, Steven Bedrick, Alexander Lazar, and Shubham Pant. 2017. Overview of the TREC 2017 Precision Medicine Track. In TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  35. Kirk Roberts, Dina Demner-Fushman, Ellen M. Voorhees, Steven Bedrick, and William R. Hersh. 2021. Overview of the TREC 2020 Precision Medicine Track. In (To appear in) TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  36. Kirk Roberts, Dina Demner-Fushman, Ellen M. Voorhees, William R. Hersh, Steven Bedrick, and Alexander J. Lazar. 2018. Overview of the TREC 2018 Precision Medicine Track. In TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  37. Kirk Roberts, Dina Demner-Fushman, Ellen M. Voorhees, William R. Hersh, Steven Bedrick, Alexander J. Lazar, Shubham Pant, and Funda Meric-Bernstam. 2019. Overview of the TREC 2019 Precision Medicine Track. In TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  38. K. Roberts, M. Simpson, D. Demner-Fushman, E. Voorhees, and W. Hersh. 2016. State-of-the-art in Biomedical Literature Retrieval for Clinical Cases: A Survey of the TREC 2014 CDS Track. Information Retrieval, Vol. 19, 1--2 (2016), 113--148. Google ScholarGoogle ScholarDigital LibraryDigital Library
  39. Kirk Roberts, Matthew S. Simpson, Ellen Voorhees, and William R. Hersh. 2015. Overview of the TREC 2015 Clinical Decision Support Track. In Text REtrieval Conference. Gaithersburg, MD.Google ScholarGoogle Scholar
  40. Stephen Robertson, Steve Walker, Susan Jones, Micheline Hancock-Beaulieu, and Mike Gatford. 1995. Okapi at TREC-3. In TREC. Gaithersburg, MD, US. https://trec.nist.gov/pubs/trec3/t3_proceedings.htmlGoogle ScholarGoogle Scholar
  41. Maciej Rybinski and Sarvnaz Karimi. 2020. CSIROmed at 2020 TREC Precision Medicine Track. In TREC. Online.Google ScholarGoogle Scholar
  42. Maciej Rybinski, Sarvnaz Karimi, and Cecile Paris. 2019. CSIRO at 2019 TREC Precision Medicine Track. In TREC. Gaithersburg, MD.Google ScholarGoogle Scholar
  43. Maciej Rybinski, Jerry Xu, and Sarvnaz Karimi. 2020. Clinical trial search: Using biomedical language understanding models for re-ranking. Journal of Biomedical Informatics, Vol. 109 (2020), 103530.Google ScholarGoogle ScholarDigital LibraryDigital Library
  44. Ellen Voorhees, Alam Tasmeer, Demner-Fushman Dina, Hersh William, and Kyle Lo. 2020. TREC-COVID: Constructing a Pandemic Information Retrieval Test Collection. ACM SIGIR Forum, Vol. 54, 1 (2020), 1--12. Google ScholarGoogle ScholarDigital LibraryDigital Library
  45. Emine Yilmaz, Evangelos Kanoulas, and Javed A Aslam. 2008. A Simple and Efficient Sampling Method for Estimating AP and NDCG. In SIGIR. Singapore, 603--610. Google ScholarGoogle ScholarDigital LibraryDigital Library
  46. Xuesi Zhou, Xin Chen, Jian Song, Gang Zhao, and Ji Wu. 2018. Team Cat-Garfield at TREC 2018 Precision Medicine Track. In TREC,, Ellen M. Voorhees and Angela Ellis (Eds.). Gaithersburg, MD.Google ScholarGoogle Scholar
  47. Huijia Zhu, Ni Yuan, Cai Peng, Qiu Zhaoming, and Cao Feng. 2012. Automatic extracting of patient-related attributes: disease, age, gender and race. Studies in health technology and informatics, Vol. 180 (2012), 589--593.Google ScholarGoogle Scholar

Index Terms

  1. Will Sorafenib Help?: Treatment-aware Reranking in Precision Medicine Search

        Recommendations

        Comments

        Login options

        Check if you have access through your login credentials or your institution to get full access on this article.

        Sign in
        • Published in

          cover image ACM Conferences
          CIKM '21: Proceedings of the 30th ACM International Conference on Information & Knowledge Management
          October 2021
          4966 pages
          ISBN:9781450384469
          DOI:10.1145/3459637

          Copyright © 2021 ACM

          Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than the author(s) must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected].

          Publisher

          Association for Computing Machinery

          New York, NY, United States

          Publication History

          • Published: 30 October 2021

          Permissions

          Request permissions about this article.

          Request Permissions

          Check for updates

          Qualifiers

          • short-paper

          Acceptance Rates

          Overall Acceptance Rate1,861of8,427submissions,22%

          Upcoming Conference

        PDF Format

        View or Download as a PDF file.

        PDF

        eReader

        View online with eReader.

        eReader