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A spatiotemporal model of polarity and spatial gradient establishment in caulobacter crescentus

Authors:

Yang CaoAuthors Info & Claims

BCB '21: Proceedings of the 12th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

Article No.: 12, Pages 1 - 10

https://doi.org/10.1145/3459930.3469539

Published: 01 August 2021 Publication History

Abstract

Bacterial cells have sophisticated intracellular organization of proteins in space and time, which allows for stress response, signal transduction, cell differentiation and morphogenesis. The mechanisms of spatial localization and their contributions to cell development and adaptability are not fully understood. In this work, we use the bacterial model organism, Caulobacter cescentus, to investigate the establishment of polarity and asymmetry. We apply a reaction-diffusion model to simulating the spatiotemporal dynamics of scaffolding proteins PodJ and PopZ, which account for the formation of distinct poles in C. crescentus. Additionally, we use this mathematical model to investigate the nonuniform distribution of key kinase DivJ and phosphatase PleC and figure out their contributions to the spatial gradient of response regulators DivK and CtrA.

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Cited By

Xu CHollis HDai MYao XWatson LCao YChen M(2022)Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cyclePLOS Computational Biology10.1371/journal.pcbi.100984718:1(e1009847)Online publication date: 28-Jan-2022
https://doi.org/10.1371/journal.pcbi.1009847

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cover image ACM Conferences

BCB '21: Proceedings of the 12th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

August 2021

603 pages

ISBN:9781450384506

DOI:10.1145/3459930

General Chairs:
Hongmei Jiang
Northwestern University
,
Xiuzhen Huang
Arkansas State University
,
Jiajie Zhang
The University of Texas Health Science Center at Houston

Copyright © 2021 ACM.

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Published: 01 August 2021

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BCB '21

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BCB '21: 12th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics

August 1 - 4, 2021

Florida, Gainesville

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Cited By

Xu CHollis HDai MYao XWatson LCao YChen M(2022)Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cyclePLOS Computational Biology10.1371/journal.pcbi.100984718:1(e1009847)Online publication date: 28-Jan-2022
https://doi.org/10.1371/journal.pcbi.1009847

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