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extended-abstract

FPGA Acceleration of Short Read Alignment

Published:21 June 2021Publication History

ABSTRACT

This work proposes a novel dataflow architecture for Smith-Waterman Matrix-fill and Traceback stages, which are at the heart of short-read alignment on NGS data. The FPGA accelerator is coupled with radical software restructuring to widely-used Bowtie2 aligner to deliver end-to-end speedup while preserving accuracy.

References

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    • Published in

      cover image ACM Other conferences
      HEART '21: Proceedings of the 11th International Symposium on Highly Efficient Accelerators and Reconfigurable Technologies
      June 2021
      76 pages
      ISBN:9781450385497
      DOI:10.1145/3468044

      Copyright © 2021 Owner/Author

      Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author.

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      Association for Computing Machinery

      New York, NY, United States

      Publication History

      • Published: 21 June 2021

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      • extended-abstract
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      • Refereed limited

      Acceptance Rates

      Overall Acceptance Rate22of50submissions,44%
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